Sex-differences in the disposition of substituted benzamides: Pharmacokinetics of a gastroprokinetic agent (4-amino-5-chloro-2-[2-(methylsulfinyl) ethoxy]-N-[2-(diethylamino)ethyl] benzamide hydrochloride) (ML-1035) in male and female New Zealand white rabbits

1992 ◽  
Vol 13 (9) ◽  
pp. 681-691 ◽  
Author(s):  
Niranjan Rao ◽  
Kenneth W Otis ◽  
Kin-Kai Hwang
Keyword(s):  
Sex Differences ◽  
New Zealand ◽  
Male And Female ◽  
New Zealand White Rabbits ◽  
Substituted Benzamides

Effects of dehydration on the heat tolerance of male and female New Zealand White rabbits

1990 ◽  
Vol 115 (3) ◽  
pp. 437-440
Author(s):  
C. J. Thwaites ◽  
N. B. Baillie ◽  
W. Kasa
Keyword(s):  
Drinking Water ◽  
New Zealand ◽  
Heat Tolerance ◽  
Rectal Temperature ◽  
Genetic Studies ◽  
Male And Female ◽  
New Zealand White Rabbits ◽  
Males And Females ◽  
The Tropics ◽  
Skin Temperatures

SUMMARYMale and female New Zealand White rabbits were exposed for 3h to 34 °C and 36 °C (both at 40% r.h.) when hydrated and dehydrated. Females had lower rectal and skin temperatures and respiratory rates than males (P < 0·001). Differences between the sexes in rectal temperature were greater at 36 °C than at 34 °C. Withholding water for 24h significantly increased the responses in rectal temperature; the differentials between hydrated and dehydrated males and females being 0·3 °C and 0·2 °C, respectively. In contrast, respiratory rates were lower in dehydrated than in hydrated rabbits, suggesting that the former were attempting water homeostatis at the expense of thermoregulation.The results suggest that the performance of rabbits in the tropics is likely to be maximized when drinking water is available at all times, and that of males, particularly breeding bucks, might be improved simply by housing them in the coolest available location. Significant individual differences in observed responses point to the need for genetic studies of heat tolerance and the possibility of developing better adapted genotypes.

scholarly journals Reversible Fibroadenomatous Mammary Hyperplasia in Male and Female New Zealand White Rabbits Associated with Cyclosporine A Administration

2009 ◽  
Vol 46 (6) ◽  
pp. 1144-1148 ◽  
Author(s):  
P. M. Krimer ◽  
S. B. Harvey ◽  
U. Blas-Machado ◽  
J. D. Lauderdale ◽  
P. A. Moore
Keyword(s):  
New Zealand ◽  
Cyclosporine A ◽  
Male And Female ◽  
New Zealand White Rabbits ◽  
Mammary Hyperplasia

scholarly journals Ectoparasites and Endoparasites of New Zealand White Rabbits from North West of Iran

2020 ◽  
Author(s):  
Nasser HAJIPOUR ◽  
Mohammad ZAVARSHANI
Keyword(s):  
New Zealand ◽  
Sporulated Oocyst ◽  
Sarcoptes Scabiei ◽  
Skin Scraping ◽  
Male And Female ◽  
North West ◽  
Potential Source ◽  
Significant Difference ◽  
New Zealand White Rabbits ◽  
Potential Risks

Background: Rabbits contain several parasites that can be harmful to their health as well as human being’s health due to the probability of causing parasitic zoonosis. The present research was designed to study ectoparasites and endoparasites of New Zealand White rabbits in North West of Iran and potential risks of parasitic zoonosis for researchers and owners. Methods: Totally, 50 rabbits were purchased from rabbit sellers and breeders in suburbs of Urmia and Tabriz between Jul and Dec 2016. The rabbits were assessed for ectoparasites by hair brushing, skin scraping, acetate tape preparation and othic swabs. They were euthanized and inspected for helminths and protozoa infection. Faecal sampling was carried out directly from recti and the oocysts or cysts were isolated using sedimentation and floatation techniques and the sporulated oocyst were identified based on morphological. Results: The following parasites, with their respective prevalence; Nematoda: Passalurus ambigus 54%, Trichostrongylus retortaeformis 42%, Nematodirus leporis 32%, Cestoda: Cysticercus pisiformis 26%, Protozoa: Eimeria steidae 44%, E. magna 30%, E. media 12% and Arthropoda: Sarcoptes scabiei 18% and Cheyletiella parasitivorax 38%. No significant difference was recorded in infection rate between male and female rabbits. Conclusion: Both domestic and wild rabbits are a potential source of human parasitic zoonosis, and strict hygienic practices are recommended during and after handling rabbits or in case of exposure to their feces.

scholarly journals Steroid metabolism in the rabbit. Biliary and urinary excretion of metabolites of [4-14C]cortisone

1970 ◽  
Vol 117 (2) ◽  
pp. 263-265 ◽  
Author(s):  
W. Taylor
Keyword(s):  
Aqueous Solution ◽  
New Zealand ◽  
Urinary Excretion ◽  
Single Injection ◽  
Steroid Metabolism ◽  
Equal Proportion ◽  
Male And Female ◽  
New Zealand White Rabbits ◽  
The Mean ◽  
Total Excretion

1. [4-14C]Cortisone was administered to anaesthetized male and female New Zealand White rabbits as a single injection or as a 45–60min infusion. 2. The method of administration of the steroid did not significantly affect the total excretion of radioactivity in bile and urine [83.8±10.8%(s.d.)]. 3. The mean ratio of metabolites in urine to those in bile was 0.97±0.23% (range 0.64–1.3). 4. When bile and urine samples were hydrolysed successively by β-glucuronidase, cold acid and hot acid, neutral metabolites extracted by ethyl acetate–ether were found mainly after hydrolysis by β-glucuronidase. 5. An approximately equal proportion of the dose was converted into substances not extractable from alkaline aqueous solution after hydrolysis.

scholarly journals Steroid metabolism in the rabbit. Biliary and urinary excretion of metabolites of [4-14C]progesterone

1965 ◽  
Vol 97 (1) ◽  
pp. 89-94 ◽  
Author(s):  
W Taylor ◽  
T Scratcherd
Keyword(s):  
Single Dose ◽  
New Zealand ◽  
Urinary Excretion ◽  
Alkaline Solution ◽  
Single Injection ◽  
Steroid Metabolism ◽  
Apparent Difference ◽  
Total Recovery ◽  
Male And Female ◽  
New Zealand White Rabbits

1. [4-(14)C]Progesterone was administered intravenously to anaesthetized male and female New Zealand White rabbits as a single injection or as a 45-60min. infusion. 2. After a single dose about 60% of the radioactivity was recovered in 6hr., and twice as much radioactivity was present in bile as in urine. After infusion total recovery of radioactivity was only about 40% in 6hr., but the relative proportions of metabolites in bile and urine were about the same as after a single dose. 3. Bile and urine samples were hydrolysed successively by beta-glucuronidase, cold acid and hot acid. 4. In bile the major proportion of metabolites appeared in the glucuronide fraction; in urine beta-glucuronidase hydrolysis yielded the greatest amounts of ether-extractable radioactivity, but the greatest proportion of radioactivity could not be extracted by ether from an alkaline solution of the hydrolysed urine. 5. There was no apparent difference in the quantity or distribution of metabolites excreted by male and female animals.

A Cytochemical Study of Glucose-6-Phosphatase (G-6-PASE) in Cells Participating in Atherogenesis of Rabbit Aorta

1975 ◽  
Vol 33 ◽  
pp. 460-461
Author(s):  
Sidney D. Kobernick ◽  
Edna A. Elfont ◽  
Neddra L. Brooks
Keyword(s):  
Lipid Metabolism ◽  
New Zealand ◽  
Aortic Wall ◽  
Rabbit Aorta ◽  
Plaque Formation ◽  
Metabolic Changes ◽  
Atherosclerotic Plaques ◽  
Cytochemical Study ◽  
Cellular Alteration ◽  
New Zealand White Rabbits

This cytochemical study was designed to investigate early metabolic changes in the aortic wall that might lead to or accompany development of atherosclerotic plaques in rabbits. The hypothesis that the primary cellular alteration leading to plaque formation might be due to changes in either carbohydrate or lipid metabolism led to histochemical studies that showed elevation of G-6-Pase in atherosclerotic plaques of rabbit aorta. This observation initiated the present investigation to determine how early in plaque formation and in which cells this change could be observed.Male New Zealand white rabbits of approximately 2000 kg consumed normal diets or diets containing 0.25 or 1.0 gm of cholesterol per day for 10, 50 and 90 days. Aortas were injected jin situ with glutaraldehyde fixative and dissected out. The plaques were identified, isolated, minced and fixed for not more than 10 minutes. Incubation and postfixation proceeded as described by Leskes and co-workers.

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