Distribution kinetics of FK-506, a novel immunosuppressant, after intravenous administration to rats in comparison with cyclosporin A

1992 ◽  
Vol 13 (5) ◽  
pp. 345-355 ◽  
Author(s):  
Kanji Takada ◽  
Hisato Usuda ◽  
Mamoru Oh-Hashi
Keyword(s):  
Cyclosporin A ◽  
Intravenous Administration ◽  
Fk 506 ◽  
Distribution Kinetics ◽  
Kinetics Of

Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients

Diabetes ◽  
1993 ◽  
Vol 42 (12) ◽  
pp. 1753-1759 ◽  
Author(s):  
A. J. Krentz ◽  
B. Dousset ◽  
D. Mayer ◽  
P. McMaster ◽  
J. Buckels ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cyclosporin A ◽  
Metabolic Effects ◽  
Transplant Recipients ◽  
Fk 506 ◽  
Liver Transplant Recipients

Interphase distribution of 2-furylethylenes

1985 ◽  
Vol 50 (8) ◽  
pp. 1642-1647 ◽  
Author(s):  
Štefan Baláž ◽  
Anton Kuchár ◽  
Ernest Šturdík ◽  
Michal Rosenberg ◽  
Ladislav Štibrányi ◽  
...  
Keyword(s):  
Partition Coefficient ◽  
Partition Coefficients ◽  
Transport Rate ◽  
Phase System ◽  
Two Phase ◽  
Interphase Distribution ◽  
Distribution Kinetics ◽  
System 1 ◽  
Kinetics Of

The distribution kinetics of 35 2-furylethylene derivatives in two-phase system 1-octanol-water was investigated. The transport rate parameters in direction water-1-octanol (l1) and backwards (l2) are partition coefficient P = l1/l2 dependent according to equations l1 = logP - log(βP + 1) + const., l2 = -log(βP + 1) + const., const. = -5.600, β = 0.261. Importance of this finding for assesment of distribution of compounds under investigation in biosystems and also the suitability of the presented method for determination of partition coefficients are discussed.

The Distribution Kinetics of Topical14C‐Sulfur Mustard in Rabbit Ocular Tissues and the Effect of Acetylcysteine

2003 ◽  
Vol 22 (4) ◽  
pp. 201-214 ◽  
Author(s):  
A. Amir ◽  
T. Kadar ◽  
S. Chapman ◽  
J. Turetz ◽  
A. Levy ◽  
...  
Keyword(s):  
Sulfur Mustard ◽  
Ocular Tissues ◽  
Distribution Kinetics ◽  
Kinetics Of

158Lipoprotein patterns in liver transplant patients: A comparison between cyclosporin A and FK 506

2000 ◽  
Vol 6 (3) ◽  
pp. C40-C40
Author(s):  
I GRAZIADEI ◽  
M LAIMER ◽  
K NACHBAUR ◽  
C EBENBICHLER ◽  
A KONIGSRAINER ◽  
...  
Keyword(s):  
Liver Transplant ◽  
Cyclosporin A ◽  
Fk 506 ◽  
Transplant Patients

Single-dose kinetics of deuterium-labelled cannabidiol in man after smoking and intravenous administration

1986 ◽  
Vol 13 (2) ◽  
pp. 77-83 ◽  
Author(s):  
Agneta Ohlsson ◽  
Jan-Erik Lindgren ◽  
Susanne Andersson ◽  
Stig Agurell ◽  
Hampton Gillespie ◽  
...  
Keyword(s):  
Single Dose ◽  
Intravenous Administration ◽  
Kinetics Of

The Mechanism of Action of FK-506 and Cyclosporin A

2006 ◽  
Vol 696 (1) ◽  
pp. 9-19 ◽  
Author(s):  
GREG WIEDERRECHT ◽  
ELSA LAM ◽  
SHIRLEY HUNG ◽  
MARY MARTIN ◽  
NOLAN SIGAL
Keyword(s):  
Cyclosporin A ◽  
Mechanism Of Action ◽  
Fk 506

Failure of FK-506, a new immunosuppressant, to prevent cerebral vasospasm in a canine two-hemorrhage model

1993 ◽  
Vol 79 (5) ◽  
pp. 710-715 ◽  
Author(s):  
Kazuya Nagata ◽  
Tomio Sasaki ◽  
Junichi Iwama ◽  
Takashi Mori ◽  
Shoko Iwamoto ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Cerebral Vasospasm ◽  
Basilar Artery ◽  
Interleukin 1 ◽  
Interleukin 2 ◽  
Muscle Layer ◽  
Treated Group ◽  
Control Group ◽  
Fk 506 ◽  
Content Type

✓ In order to clarify the possible role of immunological reaction in the pathogenesis of cerebral vasospasm, the authors examined the prophylactic effect of the immunosuppressant agents FK-506 and cyclosporin A on chronic vasospasm in a canine two-hemorrhage model. While a mean constriction of the basilar artery to 81.0% ± 4.0% (± standard error of the mean) occurred on Day 2 and to 63.8% ± 3.5% on Day 7 in the untreated group, constriction to 77.9% ± 3.4% on Day 2 and 62.8% ± 3.0% on Day 7 was demonstrated in the FK-506-treated group (difference not significant). This tendency was also noted in the cyclosporin A-treated group, with basilar artery constriction to 81.8% ± 3.7% and 56.3% ± 2.7%, respectively (difference not significant). The histological changes of the basilar artery, including corrugation of the elastic lamina, detachment of endothelial cells, and vacuolar formation in the smooth-muscle layer were not different in the two treated groups and the one control group. Since these immunosuppressant agents are known to inhibit the release of interleukin-2 (IL-2), the level of IL-2 was examined in the cerebrospinal fluid of patients with cerebral vasospasm. While interleukin-1 gradually increased in level as time passed, the level of IL-2 was consistently low during the course of the study, indicating less participation of IL-2 in the pathogenesis of cerebral vasospasm. This clinical observation matched the experimental results. The authors conclude that cell-mediated immunoreaction, initiated mainly by IL-2, plays little role in the pathogenesis of cerebral vasospasm.

K, Cl, and H2O entry in endolymph, perilymph, and cerebrospinal fluid of the rat

1982 ◽  
Vol 243 (2) ◽  
pp. F173-F180 ◽  
Author(s):  
O. Sterkers ◽  
G. Saumon ◽  
P. Tran Ba Huy ◽  
C. Amiel
Keyword(s):  
Cerebrospinal Fluid ◽  
Potassium Chloride ◽  
Intravenous Administration ◽  
Compartmental Analysis ◽  
Water Entry ◽  
Scala Tympani ◽  
Rapid Turnover ◽  
Kinetics Of ◽  
Scala Vestibuli

The kinetics of radioactive potassium, chloride, and water entry into endolymph, perilymph, and cerebrospinal fluid were studied after intravenous administration of tracers in anesthetized and nephrectomized rats. Samples of cochlear endolymph, perilymph of scala vestibuli, perilymph of scala tympani, and cisternal cerebrospinal fluid were obtained. The data showed: 1) a rapid turnover of water in endolymph, perilymph, and cerebrospinal fluid, since 3H2O equilibrated with plasma in a few minutes; 2) a slow entry of 42K and 36Cl in perilymph, since 36Cl equilibrated with plasma after 2 h and 42K did not at 6 h; 3) an extremely slow entry of 42K and 36Cl in endolymph, since no equilibrium with plasma was obtained within the 5 h of the experiments. The comparison of the compartmental analysis of our data with the results of other studies using perilymphatic perfusion of tracers indicated that perilymph rather than plasma may be considered as the precursor of endolymph.

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