Characterization of WR-1065 absorption in the rat small intestine

1991 ◽  
Vol 12 (4) ◽  
pp. 275-284 ◽  
Author(s):  
R. S. Geary ◽  
N. F. Swynnerton ◽  
S. F. Timmons ◽  
D. J. Mangold
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine

Region-dependent disappearance of vinblastine in rat small intestine and characterization of its P-glycoprotein-mediated efflux system

2000 ◽  
Vol 11 (4) ◽  
pp. 317-324 ◽  
Author(s):  
Akira Nakayama ◽  
Hiroshi Saitoh ◽  
Masako Oda ◽  
Masahiko Takada ◽  
Bruce J Aungst
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine ◽  
Efflux System ◽  
P Glycoprotein

scholarly journals Characterization of aminocephalosporin transport across rat small intestine.

1983 ◽  
Vol 6 (4) ◽  
pp. 246-253 ◽  
Author(s):  
TOSHIKIRO KIMURA ◽  
TAKAO YAMAMOTO ◽  
MASAYUKI MIZUNO ◽  
YOSHIE SUGA ◽  
SUMIKO KITADE ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine

S20.9 An insoluble mucin complex from rat small intestine ? Characterization of two different glycosylated domains

1993 ◽  
Vol 10 (4) ◽  
pp. 344-344 ◽  
Author(s):  
I. Carlstedt ◽  
A. Herrmann ◽  
H. Karlsson ◽  
J. K. Sheehan ◽  
L. -A. Fransson ◽  
...  
Keyword(s):  
Small Intestine ◽  
Rat Small Intestine

Structural characterization of glycolipids of rat small intestine having one to eight hexoses in a linear sequence

1982 ◽  
Vol 213 (2) ◽  
pp. 708-725 ◽  
Author(s):  
Jonas Ångström ◽  
Michael E. Breimer ◽  
Karl-Erik Falk ◽  
Gunnar C. Hansson ◽  
Karl-Andres Karlsson ◽  
...  
Keyword(s):  
Small Intestine ◽  
Structural Characterization ◽  
Rat Small Intestine ◽  
Linear Sequence

Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model

2008 ◽  
Vol 294 (3) ◽  
pp. G660-G668 ◽  
Author(s):  
Katsuhisa Inoue ◽  
Yasuhiro Nakai ◽  
Sayaka Ueda ◽  
Shunsuke Kamigaso ◽  
Kin-ya Ohta ◽  
...  
Keyword(s):  
Small Intestine ◽  
Transport System ◽  
Functional Characterization ◽  
Cellular Membrane ◽  
Molecular Entity ◽  
Xenopus Laevis Oocytes ◽  
Rat Small Intestine ◽  
Distribution Profile ◽  
Folate Transport

Proton-coupled folate transporter/heme carrier protein 1 (PCFT/HCP1) has recently been identified as a transporter that mediates the translocation of folates across the cellular membrane by a proton-coupled mechanism and suggested to be the possible molecular entity of the carrier-mediated intestinal folate transport system. To further clarify its role in intestinal folate transport, we examined the functional characteristics of rat PCFT/HCP1 (rPCFT/HCP1) expressed in Xenopus laevis oocytes and compared with those of the carrier-mediated folate transport system in the rat small intestine evaluated by using the everted tissue sacs. rPCFT/HCP1 was demonstrated to transport folate and methotrexate more efficiently at lower acidic pH and, as evaluated at pH 5.5, with smaller Michaelis constant ( Km) for the former (2.4 μM) than for the latter (5.7 μM), indicating its characteristic as a proton-coupled folate transporter that favors folate than methotrexate as substrate. rPCFT/HCP1-mediated folate transport was found to be inhibited by several but limited anionic compounds, such as sulfobromophthalein and sulfasalazine. All these characteristics of rPCFT/HCP1 were in agreement with those of carrier-mediated intestinal folate transport system, of which the Km values were 1.2 and 5.8 μM for folate and methotrexate, respectively, in the rat small intestine. Furthermore, the distribution profile of the folate transport system activity along the intestinal tract was in agreement with that of rPCFT/HCP1 mRNA. This study is the first to clone rPCFT/HCP1, and we successfully provided several lines of evidence that indicate its role as the molecular entity of the intestinal folate transport system.

Characterization of the Cytochrome P450 CYP2J4: Expression in Rat Small Intestine and Role in Retinoic Acid Biotransformation from Retinal

1998 ◽  
Vol 353 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Qing-Yu Zhang ◽  
Gregory Raner ◽  
Xinxin Ding ◽  
Deborah Dunbar ◽  
Minor J. Coon ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Small Intestine ◽  
Retinoic Acid ◽  
Rat Small Intestine
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