Pharmacokinetics and dose linearity testing of methylprednisolone phosphate

1989 ◽  
Vol 10 (5) ◽  
pp. 453-464 ◽  
Author(s):  
Helmut Möllmann ◽  
Peter Rohdewald ◽  
Jürgen Barth ◽  
Matthi Verho ◽  
Hartmut Derendorf
Keyword(s):  
Dose Linearity ◽  
Linearity Testing

Dose Linearity Testing of Intravenous Ofloxacin, a Novel Gyrase Inhibitor

Chemotherapy ◽  
1988 ◽  
Vol 34 (3) ◽  
pp. 170-177 ◽  
Author(s):  
M. Verho ◽  
A. Korn ◽  
M. Badian ◽  
V. Malerczyk ◽  
W. Waldhäusl
Keyword(s):  
Dose Linearity ◽  
Linearity Testing

Dose linearity testing of intravenous cefpirome (HR 810), a novel cephalosporin derivate

Infection ◽  
1987 ◽  
Vol 15 (3) ◽  
pp. 202-206 ◽  
Author(s):  
L. Maaß ◽  
M. Verho ◽  
V. Malerczyk ◽  
P. Hajdú ◽  
K. Seeger ◽  
...  
Keyword(s):  
Dose Linearity ◽  
Linearity Testing

Dose Linearity and Proportionality

2020 ◽  
pp. 695-714
Author(s):  
Tanja Eisenblaetter ◽  
Lenore Teichert ◽  
Ronald Burnette ◽  
Paul Hutson
Keyword(s):  
Dose Linearity

Linearity Testing/Testing Hadamard Codes

2016 ◽  
pp. 1107-1110 ◽  
Author(s):  
Sofya Raskhodnikova ◽  
Ronitt Rubinfeld
Keyword(s):  
Hadamard Codes ◽  
Linearity Testing

scholarly journals Linearity testing in characteristic two

2002 ◽  
Author(s):  
M. Bellare ◽  
D. Coppersmith ◽  
J. Hastad ◽  
M. Kiwi ◽  
M. Sudan
Keyword(s):  
Characteristic Two ◽  
Linearity Testing

scholarly journals O20 Dose-linearity of the pharmacokinetics of an intravenous [14C]midazolam microdose in children

2019 ◽  
Vol 104 (6) ◽  
pp. e9.1-e9
Author(s):  
BD van Groen ◽  
WHJ Vaes ◽  
BK Park ◽  
EHJ Krekels ◽  
E van Duijn ◽  
...  
Keyword(s):  
Drug Disposition ◽  
Plasma Concentrations ◽  
Volume Of Distribution ◽  
Developmental Changes ◽  
Developmentally Regulated ◽  
Age Related ◽  
Dose Linearity ◽  
Significant Difference ◽  
Therapeutic Doses ◽  
Cyp3a Enzyme

BackgroundDrug disposition in children may vary from adults due to age-related variation in drug metabolism, but paediatric pharmacokinetic (PK) studies are challenging. Microdose studies present an innovation to study PK in paediatrics, and can only be used when the PK of a microdose are dose-linear to a therapeutic dose. We aimed to assess dose-linearity of [14C]midazolam (MDZ), a marker for the activity of the developmentally regulated CYP3A enzyme, by comparing the PK of an intravenous (IV) [14C]MDZ microtracer given simultaneously with therapeutic MDZ, with the PK of a single IV [14C]MDZ microdose.MethodsPreterm to 2-year-old infants admitted to the intensive care unit received [14C]MDZ IV either as a microtracer during therapeutic MDZ infusion or as an isolated microdose. Dense blood sampling was done up to 36 hours after dosing. Plasma concentrations of [14C]MDZ and [14C]1-OH-MDZ were determined by accelerator mass spectrometry. A population PK model was developed with NONMEM 7.4 to study whether there was a difference in the PK of the microtracer versus those of a microdose [14C]MDZ.ResultsOf fifteen children (median gestational age 39.4 [range 23.9–41.4] weeks, postnatal age 11.4 [0.6–49.1] weeks), nine received a microdose and six a microtracer [14C]MDZ (111 Bq/kg; 37.6 ng/kg). In a two-compartment PK model, bodyweight was the most significant covariate for volume of distribution. There was no statistically significant difference in any PK parameter between the [14C]MDZ microdose or microtracer, suggesting the PK of MDZ to be linear within the range of the therapeutic doses and microdoses.ConclusionOur data supports the dose-linearity of an IV [14C]MDZ microdose in children, thus a [14C]MDZ microdosing approach can be used to study developmental changes in hepatic CYP3A activity.Disclosure(s)This project was funded by the ZonMw ERA-NET PRIOMEDCHILD programme (projectnumber 113205022). * both authors contributed equally

scholarly journals Development of Novel Real-Time Radiation Systems Using 4-Channel Sensors

Sensors ◽  
2020 ◽  
Vol 20 (9) ◽  
pp. 2741
Author(s):  
Yohei Inaba ◽  
Masaaki Nakamura ◽  
Masayuki Zuguchi ◽  
Koichi Chida
Keyword(s):  
Radiation Exposure ◽  
Dose Rate ◽  
Real Time ◽  
Angular Dependence ◽  
The Novel ◽  
Medical Radiation ◽  
Dose Linearity ◽  
Tissue Injuries ◽  
Low Sensitivity ◽  
Shape And Size

Radiation-related tissue injuries after medical radiation procedures, such as fluoroscopically guided intervention (FGI), have been reported in patients. Real-time monitoring of medical radiation exposure administered to patients during FGI is important to avoid such tissue injuries. In our previous study, we reported a novel (prototype) real-time radiation system for FGI. However, the prototype sensor indicated low sensitivity to radiation exposure from the side and back, although it had high-quality fundamental characteristics. Therefore, we developed a novel 4-channel sensor with modified shape and size than the previous sensor, and evaluated the basic performance (i.e., measured the energy, dose linearity, dose rate, and angular dependence) of the novel and previous sensors. Both sensors of our real-time dosimeter system demonstrated the low energy dependence, excellent dose linearity (R2 = 1.0000), and good dose rate dependence (i.e., within 5% statistical difference). Besides, the sensitivity of 0° ± 180° in the horizontal and vertical directions was almost 100% sensitivity for the new sensor, which significantly improved the angular dependence. Moreover, the novel dosimeter exerted less influence on X-ray images (fluoroscopy) than other sensors because of modifying a small shape and size. Therefore, the developed dosimeter system is expected to be useful for measuring the exposure of patients to radiation doses during FGI procedures.

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