Effect of Nigella sativa oil on pharmacokinetics and pharmacodynamics of gliclazide in rats

2021 ◽  
Author(s):  
Jeffry Adiwidjaja ◽  
Lucy Sasongko
Keyword(s):  
Nigella Sativa ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Nigella Sativa Oil

The protective effect of Nigella Sativa oil extract against neurotoxicity induced by Valproic acid

2017 ◽  
Vol 6 (9) ◽  
pp. 5474 ◽  
Author(s):  
Basant Mahmoud Morsy ◽  
Ghada Mohamed Safwat ◽  
Doaa Ahmed Hussein ◽  
Reem Mohamed Samy
Keyword(s):  
Valproic Acid ◽  
Nigella Sativa ◽  
Liver Lipid ◽  
Black Cumin ◽  
Enzymatic Antioxidant ◽  
Nigella Sativa Oil ◽  
Active Chemical ◽  
Oil Extract ◽  
Liver Lipid Peroxidation

Nigella sativa (NS), commonly known as black cumin, has been used for medicinal purposes. Traditionally the seeds and its oil are used in several diseases. The greatest part of the remedial properties of this plant is due to the presence of thymoquinone (TQ) which is a major active chemical component of the essential oil. The current study performed to evaluate the effect of Nigella sativa Oil (NSO) extract on the neurotoxic and hepatotoxic potentials from Valproic acid (VPA) administration. Also we summarize recent findings emphasizing the role of main neurotoxic and hepatotoxic markers and oxidative stress in study’s case. Neurotoxicity was induced by VPA at dose of (500 mg/kg b.wt) by gastric intubation daily for 30 day. These rats received NSO extract was given orally at dose of (0.5 ml/kg b.wt) daily for 30 days after VPA administration. The current results revealed that NSO extract treatment ameliorated significantly the elevated levels of the neurotoxic and hepatotoxic biomarkers which elevated as a result to VPA administration. Moreover, NSO extract treatment ameliorated the non-enzymatic antioxidant, brain and liver lipid peroxidation (LPO) and glutathione (GSH) concentration and the enzymatic antioxidant, brain and liver catalase(CAT) activity.

scholarly journals Protective effects of Nigella sativa oil against carboplatin-induced liver damage in rats

2019 ◽  
Vol 110 ◽  
pp. 742-747 ◽  
Author(s):  
Zuleyha Erisgin ◽  
Melahat Atasever ◽  
Kadir Cetinkaya ◽  
Saadet Özen Akarca Dizakar ◽  
Suna Omeroglu ◽  
...  
Keyword(s):  
Liver Damage ◽  
Nigella Sativa ◽  
Protective Effects ◽  
Nigella Sativa Oil

scholarly journals Effect of Nigella sativa against cisplatin induced nephrotoxicity in rats

2018 ◽  
Vol 7 (2) ◽  
Author(s):  
Amnah M.A. Alsuhaibani
Keyword(s):  
Vitamin D ◽  
Seed Treatment ◽  
Mineral Content ◽  
Renal Toxicity ◽  
Nigella Sativa ◽  
Bioactive Components ◽  
Sprague Dawley ◽  
Nigella Sativa Oil ◽  
Sprague Dawley Rats ◽  
Nigella Sativa Seed

In this study, the gross composition and mineral content of Nigella sativa seed powder (NSP) and fatty acid composition of Nigella sativa oil (NSO) were investigated. The ability of NSP, extract (NSE) and NSO in reducing the effects of cisplatin-induced renal toxicity in Sprague-Dawley rats were examined. The obtained results showed that NSP contains high amounts of carbohydrates, protein, and fiber while NSO has higher amounts of linoleicacid, oleic acid, and myristic acid. Rats treated with NSP, NSO, and NSE exhibitedreducedserum levels of urea, creatinine, and potassium, and a significant increase of Na, Na/K, vitamin D, nutritional markers, and antioxidant enzymes compared to the cisplatin-induced renal toxicity group receiving no Nigella sativa seed treatment. This study determined that all powder, oil, and extracts of N. sativa contain potent bioactive components that may aid in treatment against cisplatininduced renal toxicity in rats.

scholarly journals Study of the Effect of Nigella Sativa Oil and Its Loaded Nanoparticles on Acute Cystic Echinoncoccosis in Experimentally Infected Mice

2020 ◽  
Vol 5 (2) ◽  
pp. 1-7
Author(s):  
I.M. Nagati ◽  
I.R. Ali ◽  
N.S. Aly ◽  
H.S. Ali ◽  
M.M. fawzy ◽  
...  
Keyword(s):  
Nigella Sativa ◽  
Nigella Sativa Oil
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