Stable solid dispersion of lurasidone hydrochloride with augmented physicochemical properties for the treatment of schizophrenia and bipolar disorder

2020 ◽  
Vol 41 (8-9) ◽  
pp. 334-351
Author(s):  
Vishwas P. Pardhi ◽  
Swaran Flora
Keyword(s):  
Bipolar Disorder ◽  
Physicochemical Properties ◽  
Solid Dispersion ◽  
Lurasidone Hydrochloride

scholarly journals Physicochemical properties of phenobarbital solid dispersion with phosphatidylcholine.

1990 ◽  
Vol 38 (8) ◽  
pp. 2237-2241 ◽  
Author(s):  
Makiko FUJII ◽  
Katsuhiro HARADA ◽  
Mitsuo MATSUMOTO
Keyword(s):  
Physicochemical Properties ◽  
Solid Dispersion

Effect of hydroxypropylcellulose and Tween 80 on physicochemical properties and bioavailability of ezetimibe-loaded solid dispersion

2015 ◽  
Vol 130 ◽  
pp. 26-31 ◽  
Author(s):  
Rehmana Rashid ◽  
Dong Wuk Kim ◽  
Fakhar ud Din ◽  
Omer Mustapha ◽  
Abid Mehmood Yousaf ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Solid Dispersion ◽  
Tween 80

scholarly journals FORMULATION AND EVALUATION OF TELMISARTAN SOLID DISPERSIONS USING ENTADA SCANDENS SEED STARCH AND POLOXAMER-188 AS SUPERDISINTEGRANTS

2018 ◽  
Vol 11 (9) ◽  
pp. 474
Author(s):  
Venkatarao Mannem ◽  
Vidyadhara Suryadevara ◽  
Sandeep Doppalapudi
Keyword(s):  
Physicochemical Properties ◽  
Sodium Hydroxide ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Solid Dispersions ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Differential Scanning Calorimetric ◽  
Poloxamer 188

Objective: The current research focuses on solubility enhancement of poorly water-soluble drug telmisartan, using novel superdisintegrants such as Entada scandens seed starch and Poloxamer-188. Starches yielded from plants are pharmaceutically useful as binders, diluents, disintegrants, and lubricants.Methods: Starches were extracted from E. scandens seed powder using alkali method (sodium hydroxide at 0.1%, 0.25%, and 0.5% concentrations) and water. These starches were subjected for the evaluation of various physicochemical properties and phytochemical tests.Results: The phytochemical tests revealed the presence of only starch in all the extracts. Of all the starches, the starch prepared from 0.5% sodium hydroxide (ESS4) showed best physicochemical properties. Solid dispersions were prepared using telmisartan, poloxamer-188, and starch (ESS4) in various concentrations using fusion technique. Various pre-formulation parameters were evaluated. From in vitro dissolution studies, it was observed that the solid dispersion formulation TP7 containing telmisartan and poloxamer-188 in 1:4 ratios showed better dissolution rate. Solid dispersion TPS7 containing TP7 formulation and 15% w/w of alkali extracted starch showed faster disintegration and enhanced dissolution rate than the solid dispersions prepared alone with poloxamer-188. Fourier transform infrared spectroscopy and differential scanning calorimetric studies for optimized formulations revealed that there were no major interactions between the drug and excipients. X-ray diffraction studies revealed the crystalline and amorphous nature of formulations.Conclusion: Thus, the solid dispersions prepared using E. scandens seed starch revealed the superdisintegrant property of starch. 

scholarly journals Physicochemical Properties of Poly-vinyl Polymers and Their Influence on Ketoprofen Amorphous Solid Dispersion Performance: A Polymer Selection Case Study

Pharmaceutics ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 433 ◽  
Author(s):  
Emer Browne ◽  
Zelalem A. Worku ◽  
Anne Marie Healy
Keyword(s):  
Relative Humidity ◽  
Physicochemical Properties ◽  
Solid Dispersion ◽  
Amorphous Solid ◽  
Active Pharmaceutical Ingredient ◽  
Vinyl Pyrrolidone ◽  
Amorphous Solid Dispersion ◽  
Vinyl Polymers ◽  
Solid State Stability

When developing an amorphous solid dispersion (ASD), a prudent choice of polymer is critical to several aspects of ASD performance including: processability, solid state stability and dissolution rate. However, there is little guidance available to formulators to aid judicious polymer selection and a “trial and error” approach is often taken. This study aims to facilitate rational polymer selection and formulation design by generating ASDs using a range of poly-vinyl polymers and ketoprofen as a model active pharmaceutical ingredient (API) and evaluating several aspects of their performance. The molecular weight of the polymer and the ratio of vinyl pyrrolidone to vinyl acetate in the polymer were found to influence the relative humidity at which the relative humidity induced glass transition occurred, as well as the extent of ketoprofen supersaturation achieved during dynamic solubility testing. Interestingly, ASD tablets containing polymers with the vinyl pyrrolidone functional group exhibited higher tensile strengths than those without. This points towards the binder functionality of vinyl pyrrolidone. In conclusion, the physicochemical properties of poly-vinyl polymers greatly influence ketoprofen ASD performance and due regard should be paid to these properties in order to develop an ASD with the desired attributes.

Effect of poloxamer on physicochemical properties of tacrolimus solid dispersion improving water solubility and dissolution rate

2012 ◽  
Vol 42 (4) ◽  
pp. 171-176 ◽  
Author(s):  
Jung-Myung Ha ◽  
Seung-Yeob Kang ◽  
Chun-Woong Park ◽  
Sung-A Bin ◽  
Yun-Seok Rhee ◽  
...  
Keyword(s):  
Physicochemical Properties ◽  
Dissolution Rate ◽  
Solid Dispersion ◽  
Water Solubility
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