Pharmacokinetics and pharmacodynamics of propofol and fentanyl in patients undergoing abdominal aortic surgery - a study of pharmacodynamic drug-drug interactions

2016 ◽  
Vol 37 (5) ◽  
pp. 252-263 ◽  
Author(s):  
Paweł Wiczling ◽  
Krzysztof Bieda ◽  
Krzysztof Przybyłowski ◽  
Roma Hartmann-Sobczyńska ◽  
Agnieszka Borsuk ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Aortic Surgery ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic

scholarly journals The influence of cardiac output on propofol and fentanyl pharmacokinetics and pharmacodynamics in patients undergoing abdominal aortic surgery

2020 ◽  
Vol 47 (6) ◽  
pp. 583-596
Author(s):  
Agnieszka Bienert ◽  
Paweł Sobczyński ◽  
Katarzyna Młodawska ◽  
Roma Hartmann-Sobczyńska ◽  
Edmund Grześkowiak ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Bispectral Index ◽  
Aortic Surgery ◽  
Plasma Concentrations ◽  
Effect Compartment ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Mixed Effect ◽  
Abdominal Aortic Surgery ◽  
Age Related ◽  
Abdominal Aortic

Abstract Cardiac output (CO) is expected to affect elimination and distribution of highly extracted and perfusion rate-limited drugs. This work was undertaken to quantify the effect of CO measured by the pulse pressure method on pharmacokinetics and pharmacodynamics of propofol and fentanyl administrated during total intravenous anesthesia (TIVA). The data were obtained from 22 ASA III patients undergoing abdominal aortic surgery. Propofol was administered via target-controlled infusion system (Diprifusor) and fentanyl was administered at a dose of 2–3 µg/kg each time analgesia appeared to be inadequate. Hemodynamic measurements as well as bispectral index were monitored and recorded throughout the surgery. Data analysis was performed by using a non-linear mixed-effect population modeling (NONMEM 7.4 software). Three compartment models that incorporated blood flows as parameters were used to describe propofol and fentanyl pharmacokinetics. The delay of the anesthetic effect, with respect to plasma concentrations, was described using a biophase (effect) compartment. The bispectral index was linked to the propofol and fentanyl effect site concentrations through a synergistic Emax model. An empirical linear model was used to describe CO changes observed during the surgery. Cardiac output was identified as an important predictor of propofol and fentanyl pharmacokinetics. Consequently, it affected the depth of anesthesia and the recovery time after propofol-fentanyl TIVA infusion cessation. The model predicted (not observed) CO values correlated best with measured responses. Patients‘ age was identified as a covariate affecting the rate of CO changes during the anesthesia leading to age-related difference in individual patient’s responses to both drugs.

Pharmacokinetics and pharmacodynamics of propofol in patients undergoing abdominal aortic surgery

2012 ◽  
Vol 64 (1) ◽  
pp. 113-122 ◽  
Author(s):  
Paweł Wiczling ◽  
Agnieszka Bienert ◽  
Paweł Sobczyński ◽  
Roma Hartmann-Sobczyńska ◽  
Krzysztof Bieda ◽  
...  
Keyword(s):  
Aortic Surgery ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic

Incidence and circumstances of serum creatinine increase after abdominal aortic surgery

2003 ◽  
Vol 29 (10) ◽  
pp. 1821-1824 ◽  
Author(s):  
Frédérique Ryckwaert ◽  
Pierre Alric ◽  
Marie-Christine Picot ◽  
Kela Djoufelkit ◽  
Pascal Colson
Keyword(s):  
Serum Creatinine ◽  
Aortic Surgery ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic

A Double-blind Protocol Comparing Regional and General Anesthetic Techniques during Abdominal Aortic Surgery

1994 ◽  
Vol 81 (SUPPLEMENT) ◽  
pp. A65
Author(s):  
R. B. Gorman ◽  
EJ. Norris ◽  
MJ. Breslow ◽  
JA. Grass ◽  
C. Beattie
Keyword(s):  
Aortic Surgery ◽  
Anesthetic Techniques ◽  
General Anesthetic ◽  
Double Blind ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic

scholarly journals Delayed forced air warming prevents hypothermia during abdominal aortic surgery

1996 ◽  
Vol 76 (3) ◽  
pp. 459-460 ◽  
Author(s):  
J Karayan ◽  
D Thomas ◽  
L Lacoste ◽  
K Dhoste ◽  
J B Ricco ◽  
...  
Keyword(s):  
Aortic Surgery ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic ◽  
Forced Air Warming ◽  
Forced Air

scholarly journals Acute Renal Injury and Dysfunction Following Elective Abdominal Aortic Surgery

2007 ◽  
Vol 33 (5) ◽  
pp. 550-555 ◽  
Author(s):  
M. Tallgren ◽  
T. Niemi ◽  
R. Pöyhiä ◽  
E. Raininko ◽  
M. Railo ◽  
...  
Keyword(s):  
Renal Injury ◽  
Aortic Surgery ◽  
Acute Renal Injury ◽  
Abdominal Aortic Surgery ◽  
Abdominal Aortic
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