Kidney function changes with aging in adults: comparison between cross-sectional and longitudinal data analyses in renal function assessment

2015 ◽  
Vol 36 (9) ◽  
pp. 613-621 ◽  
Author(s):  
Sang M. Chung ◽  
David J. Lee ◽  
Austin Hand ◽  
Philip Young ◽  
Jayabharathi Vaidyanathan ◽  
...  
Keyword(s):  
Renal Function ◽  
Longitudinal Data ◽  
Kidney Function ◽  
Cross Sectional ◽  
Data Analyses ◽  
Function Assessment

scholarly journals Strong Correlation of Renal Function with Choroidal Thickness in Patients with Type 2 Diabetes: Retrospective Cross-Sectional Study

2020 ◽  
Vol 9 (7) ◽  
pp. 2171
Author(s):  
Min Gyu Choi ◽  
Jee Taek Kim
Keyword(s):  
Renal Function ◽  
Kidney Function ◽  
Cystatin C ◽  
Choroidal Thickness ◽  
Serum Phosphorus ◽  
Control Group ◽  
Phosphorus Level ◽  
Serum Phosphorus Level ◽  
Cross Sectional ◽  
Treatment Naïve

The purpose of this study was to analyze the correlation between renal function and subfoveal choroidal thickness (SFChT) in treatment-naïve proliferative diabetic retinopathy (PDR) patients. This study included 85 eyes of 52 treatment-naïve PDR patients who underwent kidney function testing and urinalysis and 42 eyes of 33 age-matched controls. Treatment-naïve eyes with PDR were categorized into pachychoroid and leptochoroid groups based on the SFChT of the control group. Kidney function profiles were compared between pachychoroid and leptochoroid groups; the relationship between kidney function profile and SFChT was evaluated using regression analysis. Compared with the pachychoroid group, the leptochoroid group had significantly higher serum creatinine (p = 0.026), cystatin C (p = 0.004), and phosphorus (p < 0.001) levels and a lower estimated glomerular filtration rate (eGFR) (p < 0.001). Multivariate linear regression analyses showed that SFChT was positively correlated with eGFR (Cystatin C) (p = 0.007) and negatively correlated with serum phosphorus (p = 0.001). SFChT of patients with eGFR < 30 mL/min/1.73 m2 and serum phosphorus level ≥4.0 mg/dL was less than that of patients with higher eGFR and lower serum phosphorus level. The choroidal thickness of treatment-naïve PDR patients is closely affected by renal function. Kidney function test should be considered if SFChT of patients with treatment-naïve PDR is reduced.

No effect of mercury exposure on kidney function during ongoing artisanal gold mining activities in Colombia

2016 ◽  
Vol 33 (1) ◽  
pp. 67-78 ◽  
Author(s):  
Luz Helena Sánchez Rodríguez ◽  
Laura Andrea Rodríguez-Villamizar ◽  
Oscar Flórez-Vargas ◽  
Yolanda Vargas Fiallo ◽  
Álvaro Ordoñez ◽  
...  
Keyword(s):  
Renal Function ◽  
Kidney Function ◽  
Gold Mining ◽  
Study Groups ◽  
Cross Sectional Study ◽  
Multiple Regression Model ◽  
Mining Activities ◽  
Cross Sectional ◽  
Disease Epidemiology ◽  
Artisanal Gold Mining

This cross-sectional study examined whether people who are exposed to mercury (Hg) vapours in ongoing artisanal gold mining activities have alteration in kidney function monitoring parameters. The study enrolled 164 miners and 127 participant controls. The Hg concentrations for miners and control participants were measured in blood (B-Hg; median 7.0 vs. 2.5 µg/L), urine (U-Hg; median 3.9 vs. 1.5 µg/g creatinine) and hair (H-Hg; median 0.8 vs. 0.4 µg/g hair). The biomarkers of renal function were creatinine, albumin and excretion of β-2 microglobulin. Glomerular filtration rate (eGFR) was calculated using the chronic kidney disease epidemiology collaboration equation. Significant statistical differences were found in Hg concentrations and eGFR levels between the two study groups ( p < 0.01) but not with the other biomarkers of renal function. A multiple regression model was applied to explore the relationship of eGFR levels and Hg concentrations. However, no association was found between the prevalence of reduced eGFR (<71.96 mL/min/1.73 m2) and the B-Hg or U-Hg levels after adjustment for covariates. Nevertheless, it was observed that having B-Hg levels above 10 µg Hg/L decreased the eGFR by 1.7 mL/min/1.73 m2 (confidence interval 95% −5.1 to 1.7) compared to having levels below 2.0 µg Hg/L. Our results found no support for kidney damage associated with Hg vapour exposure in ongoing artisanal gold mining, whose population has a level of Hg exposure from low to moderate (B-Hg from 3.4 to 11.0 µg/L and U-Hg from 1.3 to 9.6 µg/g creatinine).

scholarly journals Screening of renal function among a group of physicians working in a hospital who are often self neglected

2021 ◽  
Author(s):  
M A Kashem ◽  
Ahsan Ullah ◽  
Rajat Sanker Roy Biswas
Keyword(s):  
Renal Function ◽  
Kidney Disease ◽  
Kidney Function ◽  
Screening Program ◽  
Early Stage ◽  
Medical Officer ◽  
Population Based ◽  
Medical Professional ◽  
Early Screening ◽  
Cross Sectional

Background: Prevalence of chronic kidney disease (CKD) has been increasing rapidly worldwide and early screening to detect kidney disease, particularly at its early stages is pivotal to stop its further deterioration. Population based study on detection at early stage of kidney disease and its prevalence are scanty in our country, especially among the medical professional personnel. Hence taking advantage of the observance of World Kidney Day 2020, we conducted a screening program for kidney disease organized at the Chattogram Maa O Shishu Hospital (CMOSH) premises among a group of physicians of the hospital. Methods: This was a cross sectional observational study among 67 physicians of different ranks (medical officer to professor), working at our hospital in different discipline. Age, body weight, height, Body Mass Index (BMI), blood pressure were documented, and urinary protein and serum creatinine were measured at a single sitting. Kidney function was estimated by calculating the glomerular filtration rate (GFR) using the Modification of Diet in Renal Disease (MDRD) formula. Kidney function was classified according to estimated GFR (eGFR) and Kidney Disease Outcomes Quality Initiative (K/DOQI) guidelines. Results: A total of 67 working physicians of the hospital were studied. Among them majority subjects (30) were in the age group of 20 to 29 years. Among all 11.9% participants had proteinuria (trace to 1 plus). The distribution of eGFR was symmetrical, with the majority (70.10%) of subjects in the 60 to 89 ml/min category, 11.90% had 30 to 59 ml/min category and only 17.90% of the study population had eGFR > 90 ml/min. An inverse relation between eGFR and age, and a direct relation between eGFR and BMI were observed. Conclusion: Proteinuria, low eGFR levels might be related with future decline in renal function among the studied subjects and so regular health checkup is important to abate the potential epidemic of kidney disease among the health professionals.

scholarly journals Thyroid Function and Reduced Kidney Function with Aging in Chinese Older Adults: A Cross- sectional Study

2021 ◽  
Author(s):  
Lu Wei ◽  
Yun Bai ◽  
Yu Zhang ◽  
Zhenzhu Yong ◽  
Qun Zhang ◽  
...  
Keyword(s):  
Older Adults ◽  
Renal Function ◽  
Kidney Function ◽  
Thyroid Function ◽  
Older Individuals ◽  
Free Triiodothyronine ◽  
Older Population ◽  
Cross Sectional ◽  
Chinese Older Adults ◽  
Reduced Kidney Function

Abstract Background: Thyroid function may be a factor influencing renal function in general population. Renal function and thyroid function vary with aging, thus the association of thyroid function and declining kidney function in older adults was different from this in the young and remains controversial. The aim of this study was to estimate association between thyroid function in reference interval and reduced kidney function with aging in Chinese older adults.Methods: A total of 15729 adults, 23.3% (N= 3624) of which were older population, were collected in the health check-up department of the First Affiliated Hospital of Nanjing Medical University between January 2018 to January 2020.Basic demographic information was collected by physician-administered questionnaire. The variation tendency of thyroid function with aging was investigated by mean of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulatinghormone (TSH) in subgroups for every 10 years. Associations between kidney and thyroid function were estimated with β value by multiple linear regression and with odds ratio (OR) by multivariable logistic regression models adjusted for age, gender, body mass index and serum urine acid. Results: In the older population, an increased trend of TSH, a decreased trend of FT3 and little change of FT4 were identified with aging. Estimated glomerular filtration rate (eGFR) remarkably decreased with increasing TSH (β: -0.081) and declining FT3 (β: 0.083) concentrations. Compared with the population in the lowest FT3 quartile (3.10-4.45 pmol/L), the prevalence of eGFR< 75ml/min/1.73m2 significantly decreased by 22.0% with FT3 4.46-4.81 pmol/L, 27.6% with FT3 4.82-5.20 pmol/L and 34.9% with FT3 5.21-6.8 pmol/L in older individuals (P for trend <.001). The OR was 1.315 with high-normal TSH, comparing to low-normal TSH in older persons (P: 0.025). Similar results were found between prevalent eGFR< 60ml/min/1.73m2 and thyroid function. The prevalent reduced kidney function was not remarkably associated with FT4 in the reference range.Conclusions: This study demonstrated a significant association between thyroid function and kidney function, especially FT3 in older population. The clinician were advised to evaluate renal function with low-normal FT3 and high-normal TSH in case of potential decreased kidney function.

scholarly journals Preventing renal and cardiovascular risk by renal function assessment: insights from a cross-sectional study in low-income countries and the USA

BMJ Open ◽  
2012 ◽  
Vol 2 (5) ◽  
pp. bmjopen-2012-001357 ◽  
Author(s):  
Paolo Cravedi ◽  
Sanjib Kumar Sharma ◽  
Rodolfo Flores Bravo ◽  
Nazmul Islam ◽  
Irma Tchokhonelidze ◽  
...  
Keyword(s):  
Renal Function ◽  
Cardiovascular Risk ◽  
Low Income ◽  
Cross Sectional Study ◽  
Low Income Countries ◽  
Sectional Study ◽  
Cross Sectional ◽  
The Usa ◽  
Function Assessment

scholarly journals Protein intake and kidney function in the middle-age population: contrast between cross-sectional and longitudinal data

2014 ◽  
Vol 29 (9) ◽  
pp. 1733-1740 ◽  
Author(s):  
M. Cirillo ◽  
C. Lombardi ◽  
D. Chiricone ◽  
N. G. De Santo ◽  
A. Zanchetti ◽  
...  
Keyword(s):  
Longitudinal Data ◽  
Kidney Function ◽  
Protein Intake ◽  
Middle Age ◽  
Cross Sectional

1905: The Effect of Percutaneous Nephrolithotripsy (PCNL) on Renal Function: Assessment with Quantitative Spect of TC 99M-DMSA (QDMSA) Renal Scintigraphy

2004 ◽  
Vol 171 (4S) ◽  
pp. 503-503
Author(s):  
Boaz Moskovitz ◽  
Vladimir Sopov ◽  
Sarel Halachmi ◽  
Michael Mullerad ◽  
Yusef Barbara ◽  
...  
Keyword(s):  
Renal Function ◽  
Renal Scintigraphy ◽  
Quantitative Spect ◽  
Percutaneous Nephrolithotripsy ◽  
Function Assessment

STUDY OF RADIATION CHARACTERISTICS THE RENAL FUNCTION IN PATIENTS WITH TYPE 2 DIABETES

2014 ◽  
pp. 73-77
Author(s):  
Van Chuong Nguyen ◽  
Thi Kim Anh Nguyen
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Disease Duration ◽  
Left Kidney ◽  
Cross Sectional ◽  
The Right

Background: A Research glomerular filtration rate (GFR) of 61 patients with type 2 diabetes mellitus with renal scanning 99mTc-DTPA glomerular filtration rate at the hospital 175. Objective: (1) To study characteristics of imaging of renal function. (2) Understanding the relationship between GFR with blood sugar, HbA1c, blood pressure and albuminuria in patients with type 2 diabetes. Methods: Descriptive, prospective, cross-sectional study. Clinical examination, Clinical tests and 99mTc-DTPA GFR gamma - camera renography for patients. Result: GFR of the study group was 75,4 ± 22,3 ml/phut/1,73m2, the left kidney was 35,0 ± 13,0 is lower than the right kidney and 39,8 ± 11,9; p <0,01. There is no correlation between GFR with blood glucose and HbA1c, the risk of reduced GFR in hypertensive group associated is OR = 6,5 with p<0,01; albuminuria (+) is OR = 4,2 with p <0,01; and disease duration > 10 years is OR = 3,5 with p <0.01. Conclusion: GFR of the left kidneys is lower than the right kidney; correlation decreased GFR associated with hypertension, albuminuria and disease duration. Keywords: GFR, diabetes, albuminuria

scholarly journals Urinary Sediment Transcriptomic and Longitudinal Data to Investigate Renal Function Decline in Type 1 Diabetes

2020 ◽  
Vol 11 ◽  
Author(s):  
Maria Beatriz Monteiro ◽  
Tatiana S. Pelaes ◽  
Daniele P. Santos-Bezerra ◽  
Karina Thieme ◽  
Antonio M. Lerario ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Renal Function ◽  
Longitudinal Data ◽  
Urinary Sediment ◽  
Renal Function Decline
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