Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR

Li Liu; Ganesh M. Mugundu; Brian J. Kirby; Divya Samineni; Pankaj B. Desai; Jashvant D. Unadkat

doi:10.1002/bdd.1788

Quantification of human hepatocyte cytochrome P450 enzymes and transporters induced by HIV protease inhibitors using newly validated LC-MS/MS cocktail assays and RT-PCR

Biopharmaceutics & Drug Disposition ◽

10.1002/bdd.1788 ◽

2012 ◽

Vol 33 (4) ◽

pp. 207-217 ◽

Cited By ~ 15

Author(s):

Li Liu ◽

Ganesh M. Mugundu ◽

Brian J. Kirby ◽

Divya Samineni ◽

Pankaj B. Desai ◽

...

Keyword(s):

Cytochrome P450 ◽

Protease Inhibitors ◽

Human Hepatocyte ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Cytochrome P450 Enzymes ◽

Rt Pcr

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Complex Drug Interactions of HIV Protease Inhibitors 1: Inactivation, Induction, and Inhibition of Cytochrome P450 3A by Ritonavir or Nelfinavir

Drug Metabolism and Disposition ◽

10.1124/dmd.110.037523 ◽

2011 ◽

Vol 39 (6) ◽

pp. 1070-1078 ◽

Cited By ~ 64

Author(s):

Brian J. Kirby ◽

Ann C. Collier ◽

Evan D. Kharasch ◽

Dale Whittington ◽

Kenneth E. Thummel ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Cytochrome P450 3A ◽

Complex Drug

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Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

Drug Metabolism and Disposition ◽

10.1124/dmd.112.044677 ◽

2012 ◽

Vol 40 (8) ◽

pp. 1473-1477 ◽

Cited By ~ 38

Author(s):

Nico Holmstock ◽

Pieter Annaert ◽

Patrick Augustijns

Keyword(s):

Cytochrome P450 ◽

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Relative Role ◽

P Glycoprotein ◽

In Situ Intestinal Perfusion ◽

Glycoprotein Inhibition

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Complex Drug Interactions of HIV Protease Inhibitors 2: In Vivo Induction and In Vitro to In Vivo Correlation of Induction of Cytochrome P450 1A2, 2B6, and 2C9 by Ritonavir or Nelfinavir

Drug Metabolism and Disposition ◽

10.1124/dmd.111.038646 ◽

2011 ◽

Vol 39 (12) ◽

pp. 2329-2337 ◽

Cited By ~ 41

Author(s):

Brian J. Kirby ◽

Ann C. Collier ◽

Evan D. Kharasch ◽

Vaishali Dixit ◽

Pankaj Desai ◽

...

Keyword(s):

Cytochrome P450 ◽

Drug Interactions ◽

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Cytochrome P450 1A2 ◽

In Vivo Induction ◽

Complex Drug

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Differential Inhibition of Cytochrome P450 3A4, 3A5 and 3A7 by Five Human Immunodeficiency Virus (HIV) Protease Inhibitors in vitro

Basic & Clinical Pharmacology & Toxicology ◽

10.1111/j.1742-7843.2006.pto_249.x ◽

2006 ◽

Vol 98 (1) ◽

pp. 79-85 ◽

Cited By ~ 75

Author(s):

Marika T. Granfors ◽

Jun-Sheng Wang ◽

Lauri I. Kajosaari ◽

Jouko Laitila ◽

Pertti J. Neuvonen ◽

...

Keyword(s):

Human Immunodeficiency Virus ◽

Cytochrome P450 ◽

Protease Inhibitors ◽

Hiv Protease ◽

Cytochrome P450 3A4 ◽

Hiv Protease Inhibitors ◽

Differential Inhibition ◽

Immunodeficiency Virus

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Determining and Overcoming Resistance to HIV Protease Inhibitors

Current Drug Targets - Infectious Disorders ◽

10.2174/1568005043340984 ◽

2004 ◽

Vol 4 (2) ◽

pp. 137-152 ◽

Cited By ~ 17

Author(s):

Jana Prejdova ◽

Milan Soucek ◽

Jan Konvalinka

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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A QSAR Study of HIV Protease Inhibitors Using Theoretical Descriptors

Current Computer - Aided Drug Design ◽

10.2174/1573409911006040269 ◽

2010 ◽

Vol 6 (4) ◽

pp. 269-282 ◽

Cited By ~ 4

Author(s):

Subhash C. Basak ◽

Denise Mills ◽

Rajni Garg ◽

Barun Bhhatarai

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors ◽

Qsar Study

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Simultaneous determination of the HIV protease inhibitors indinavir, amprenavir, saquinavir, ritonavir and nelfinavir in human plasma by high-performance liquid chromatography

Journal of Chromatography B Biomedical Sciences and Applications ◽

10.1016/s0378-4347(00)00617-4 ◽

2001 ◽

Vol 755 (1-2) ◽

pp. 85-89 ◽

Cited By ~ 32

Author(s):

Harumi Yamada ◽

Hajime Kotaki ◽

Tetsuya Nakamura ◽

Aikichi Iwamoto

Keyword(s):

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Simultaneous Determination ◽

Human Plasma ◽

Protease Inhibitors ◽

High Performance ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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1351 SYNERGISTIC EFFECTS OF ALCOHOL AND HIV PROTEASE INHIBITORS ON CALCIUM HOMEOSTASIS, STRESS RESPONSE AND INJURY IN MOUSE AND HUMAN HEPATOCYTES

Journal of Hepatology ◽

10.1016/s0168-8278(12)61362-2 ◽

2012 ◽

Vol 56 ◽

pp. S531

Author(s):

C. Ji

Keyword(s):

Stress Response ◽

Protease Inhibitors ◽

Calcium Homeostasis ◽

Synergistic Effects ◽

Human Hepatocytes ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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Aminodiol HIV protease inhibitors. 2. 1,1-Dimethyl-2-hydroxyethyl carbamate derivatives with enhanced potency

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(95)00056-y ◽

1995 ◽

Vol 5 (5) ◽

pp. 459-464 ◽

Cited By ~ 3

Author(s):

G.S. Bisacchi ◽

S. Ahmad ◽

M. Alam ◽

A. Ashfaq ◽

J. Barrish ◽

...

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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Evaluation of furofuran as a P2 ligand for symmetry-based HIV protease inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(96)00528-8 ◽

1996 ◽

Vol 6 (23) ◽

pp. 2847-2852 ◽

Cited By ~ 7

Author(s):

Xiaoqi Chen ◽

Lin Li ◽

Dale J. Kempf ◽

Hing Sham ◽

Norman E. Wideburg ◽

...

Keyword(s):

Protease Inhibitors ◽

Hiv Protease ◽

Hiv Protease Inhibitors

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