Effect of the timing of food intake on the absorption and bioavailability of carbamazepine immediate-release tablets in beagle dogs

2012 ◽  
Vol 33 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Cai-hong Xu ◽  
Gang Cheng ◽  
Yi Liu ◽  
Ye Tian ◽  
Jing Yan ◽  
...  
Keyword(s):  
Food Intake ◽  
Immediate Release ◽  
Beagle Dogs

scholarly journals Physiologically Relevant In Vitro-In Vivo Correlation (IVIVC) Approach for Sildenafil with Site-Dependent Dissolution

Pharmaceutics ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 251 ◽  
Author(s):  
Tae Hwan Kim ◽  
Soyoung Shin ◽  
Seok Won Jeong ◽  
Jong Bong Lee ◽  
Beom Soo Shin
Keyword(s):  
Dissolution Kinetics ◽  
Immediate Release ◽  
Relative Bioavailability ◽  
Wet Granulation ◽  
Population Pharmacokinetic ◽  
Beagle Dogs ◽  
Concentration Time ◽  
In Vivo Dissolution

This study aimed to establish a physiologically relevant in vitro-in vivo correlation (IVIVC) model reflecting site-dependent dissolution kinetics for sildenafil based on population-pharmacokinetic (POP-PK) modeling. An immediate release (IR, 20 mg) and three sustained release (SR, 60 mg) sildenafil tablets were prepared by wet granulation method. In vitro dissolutions were determined by the paddle method at pH 1.2, 4.5, and 6.8 media. The in vivo pharmacokinetics were assessed after oral administration of the prepared IR and SR formulations to Beagle dogs (n = 12). The dissolution of sildenafil from SR formulations was incomplete at pH 6.8, which was not observed at pH 1.2 and pH 4.5. The relative bioavailability was reduced with the decrease of the dissolution rate. Moreover, secondary peaks were observed in the plasma concentration-time curves, which may result from site-dependent dissolution. Thus, a POP-PK model was developed to reflect the site-dependent dissolution by separately describing the dissolution and absorption processes, which allowed for estimation of the in vivo dissolution of sildenafil. Finally, an IVIVC was established and validated by correlating the in vitro and in vivo dissolution rates. The present approach may be applied to establish IVIVC for various drugs with complex dissolution kinetics for the development of new formulations.

scholarly journals Preliminary study: voluntary food intake in dogs during tryptophan supplementation

2011 ◽  
Vol 106 (S1) ◽  
pp. S162-S165 ◽  
Author(s):  
Víctor Fragua ◽  
Gemma González-Ortiz ◽  
Cecilia Villaverde ◽  
Marta Hervera ◽  
Valentina Maria Mariotti ◽  
...  
Keyword(s):  
Amino Acid ◽  
Food Intake ◽  
Essential Amino Acid ◽  
Beagle Dogs ◽  
Supplementation Period ◽  
Preliminary Study ◽  
Serum Ghrelin ◽  
Voluntary Food Intake

Tryptophan, a precursor of important molecules such as serotonin, melatonin and niacin, is an essential amino acid for dogs. In pigs, tryptophan supplementation has been shown to induce a significant increase in food intake. The aim of the present study was to assess whether long-term tryptophan supplementation increases voluntary food intake in dogs and to observe whether this was accompanied by a change in serum ghrelin. In the present study, sixteen adult Beagle dogs were used, with four male and four female dogs fed diets supplemented with tryptophan (1 g/dog per d) during 81 d (Trp) and four male and four female dogs that were not supplemented (control). A voluntary food intake test was performed during 5 d following the supplementation period. The Trp group tended to show a higher food intake during the voluntary food intake test (58·0 (se 5·37) v. 77·5 (se 3·65) g/kg metabolic weight per d; P = 0·074). No significant differences were found for serum ghrelin concentrations.

scholarly journals Oral Administration of Zolpidem Tartrate in an Abuse-deterrent Formulation Versus an Immediate Release Formulation in Beagle Dogs

2021 ◽  
pp. 1-6
Author(s):  
Amina Vazda ◽  
Wei Xia ◽  
Håkan Engqvist
Keyword(s):  
Controlled Release ◽  
Oral Administration ◽  
Chemical Properties ◽  
Immediate Release ◽  
Prescription Drug Abuse ◽  
Pharmacokinetic Analysis ◽  
Beagle Dogs ◽  
Release Formulation ◽  
Physical And Chemical ◽  
Plasma Profile

Objective: The continuing rise of prescription drug abuse has greatly necessitated the development of an abuse-deterrent formulation. Geopolymers are a promising base for drug design as they allow for tuneable drug release and possess superior physical and chemical properties compared with conventional pharmaceutical excipients.Methods: Geopolymer pellets containing zolpidem tartrate were administrated orally to beagle dogs as a controlled-release formulation with the commercial immediate-release product, Stilnoct® tablets, as the control.Results: The administration of zolpidem tartrate as immediate-release tablets demonstrated an elevated immediate release plasma profile and the zolpidem tartrate in the geopolymers demonstrated a controlled-release plasma profile. The pharmacokinetic analysis demonstrated that immediate-release tablet administration generated much higher plasma concentration when compared with geopolymer pellets administration for zolpidem tartrate. On the other hand, the geopolymer formulation prolonged the time of drug release.Conclusion: Oral administration of zolpidem tartrate in geopolymer pellets demonstrated a controlled-release plasma profile.

Effect of food intake on the delivery of fluorescein as a model drug in colon delivery capsule after oral administration to beagle dogs

1996 ◽  
Vol 4 (2) ◽  
pp. 59-67 ◽  
Author(s):  
Ken-Ichi Matsuda ◽  
Tomohiro Takaya ◽  
Fukiko Shimoji ◽  
Motoki Muraoka ◽  
Yukako Yoshikawa ◽  
...  
Keyword(s):  
Food Intake ◽  
Oral Administration ◽  
Beagle Dogs ◽  
Colon Delivery ◽  
Effect Of Food ◽  
Model Drug

Effects of food intake on pharmacokinetics of mosapride in beagle dogs

2015 ◽  
Vol 38 (5) ◽  
pp. 497-499 ◽  
Author(s):  
J.-W. Chae ◽  
B.-J. Song ◽  
I.-H. Baek ◽  
H.-Y. Yun ◽  
J. Y. Ma ◽  
...  
Keyword(s):  
Food Intake ◽  
Beagle Dogs

The Acute Effects of a New Type of Implantable Gastric Electrical Stimulators Featuring Varied Pulse Widths on Beagle Dogs’ Food Intake and Gastric Accommodation

2013 ◽  
Vol 24 (5) ◽  
pp. 783-790 ◽  
Author(s):  
Yanmei Li ◽  
Shukun Yao ◽  
Shaoxuan Chen ◽  
Yanli Zhang ◽  
Xiaojuan Guo ◽  
...  
Keyword(s):  
Food Intake ◽  
Acute Effects ◽  
Beagle Dogs ◽  
Gastric Accommodation ◽  
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