Age and sex‐specific reference intervals for pro‐oxidant‐antioxidant balance (PAB), anti‐heat‐shock protein 27 (Anti‐hsp27) and routine laboratory tests in the middle‐aged adult population

2021 ◽  
Author(s):  
Hamideh Ghazizadeh ◽  
Mary Kathryn Bohn ◽  
Mahdiyeh Yaghooti‐Khorasani ◽  
Roshanak Ghaffarian‐Zirak ◽  
Mohsen Valizadeh ◽  
...  
Keyword(s):  
Heat Shock ◽  
Heat Shock Protein ◽  
Laboratory Tests ◽  
Adult Population ◽  
Reference Intervals ◽  
Specific Reference ◽  
Routine Laboratory ◽  
Middle Aged ◽  
Middle Aged Adult ◽  
Age And Sex

scholarly journals Comparing Ethnicity-Specific Reference Intervals for Clinical Laboratory Tests from EHR Data

2018 ◽  
Vol 3 (3) ◽  
pp. 366-377 ◽  
Author(s):  
Nadav Rappoport ◽  
Hyojung Paik ◽  
Boris Oskotsky ◽  
Ruth Tor ◽  
Elad Ziv ◽  
...  
Keyword(s):  
Race And Ethnicity ◽  
Laboratory Tests ◽  
Clinical Laboratory ◽  
Local Population ◽  
Reference Intervals ◽  
Medical Decision ◽  
Specific Reference ◽  
Healthy Individuals ◽  
Electronic Health Record Data ◽  
Novel Approach

Abstract Background The results of clinical laboratory tests are an essential component of medical decision-making. To guide interpretation, test results are returned with reference intervals defined by the range in which the central 95% of values occur in healthy individuals. Clinical laboratories often set their own reference intervals to accommodate variation in local population and instrumentation. For some tests, reference intervals change as a function of sex, age, and self-identified race and ethnicity. Methods In this work, we develop a novel approach, which leverages electronic health record data, to identify healthy individuals and tests for differences in laboratory test values between populations. Results We found that the distributions of >50% of laboratory tests with currently fixed reference intervals differ among self-identified racial and ethnic groups (SIREs) in healthy individuals. Conclusions Our results confirm the known SIRE-specific differences in creatinine and suggest that more research needs to be done to determine the clinical implications of using one-size-fits-all reference intervals for other tests with SIRE-specific distributions.

Age- and sex-specific pediatric reference intervals for biochemistry analytes as measured with the Ektachem-700 analyzer.

1988 ◽  
Vol 34 (8) ◽  
pp. 1622-1625 ◽  
Author(s):  
G Lockitch ◽  
A C Halstead ◽  
S Albersheim ◽  
C MacCallum ◽  
G Quigley
Keyword(s):  
Calcium Phosphate ◽  
Total Protein ◽  
Reference Intervals ◽  
Specific Reference ◽  
Healthy Population ◽  
Reference Ranges ◽  
Older Children ◽  
Related Difference ◽  
Film Analyzer ◽  
Age And Sex

Abstract Using the Ektachem-700 multilayer film analyzer, we defined age- and sex-specific reference intervals for 20 analytes in sera from a healthy population of neonates and children ages one to 19 years. Upper and lower normal reference intervals for each analyte were determined by nonparametric methods as the 0.975 and 0.025 fractiles, respectively. Newborns have lower concentrations of total protein and albumin, and higher concentrations of phosphate, bilirubin, and enzymes in serum than older children do. Concentrations of urea, glucose, calcium, phosphate, and bilirubin change rapidly postnatally. Outside the neonatal period, no significant age- or sex-related difference was found for plasma glucose, serum amylase, conjugated or unconjugated bilirubin, or lipase. There was no sex-related difference in reference intervals for albumin, total protein, calcium, phosphate, or urea. However, concentrations of uric acid and creatine kinase are much higher in postpubertal boys than in girls. Alkaline phosphatase values peak later in boys. Except for lactate dehydrogenase and gamma-glutamyltransferase, the reference intervals defined here do not differ strikingly from data derived with use of other analyzers. The age- and sex-related trends are independent of method. However, each laboratory should determine the degree to which these reference ranges can be directly applied to analyses performed with another analyzer.

scholarly journals Age- and sex-specific reference intervals for the serum cystatin C/creatinine ratio in healthy children (0–18 years old)

2019 ◽  
Vol 47 (7) ◽  
pp. 3151-3159 ◽  
Author(s):  
Changjin Liu ◽  
Jing Wen ◽  
Jialin Xiang ◽  
Xuhong Ouyang ◽  
Yan Yang ◽  
...  
Keyword(s):  
Cystatin C ◽  
Pediatric Population ◽  
Age Groups ◽  
Serum Markers ◽  
Reference Intervals ◽  
Specific Reference ◽  
Healthy Children ◽  
Serum Samples ◽  
Serum Cystatin C ◽  
Age And Sex

Objective This study aimed to investigate serum levels of the cystatin C (CysC)/creatinine (Cr) ratio and renal serum markers (CysC, Cr, urea, and uric acid [UA]) for different ages and by sex. We also aimed to establish pediatric reference intervals for the serum CysC/Cr ratio. Methods Serum samples were collected from 4765 healthy children (0–18 years old). Serum markers of renal function were measured, and the CysC/Cr ratio of each participant was calculated and statistically analyzed. Results The renal marker CysC did not substantially change after 1 year old. Cr, urea, and UA levels generally increased with age. However, the serum CysC/Cr ratio steadily decreased with age. The CysC/Cr ratio showed significant differences in age among all age groups and varied with sex, except for in the 1 to 6-year-old groups. The overall serum CysC/Cr ratio in girls was higher than that in boys. Conclusion Reference intervals of the serum CysC/Cr ratio in the pediatric population were established. These intervals need to be partitioned by age and sex.

scholarly journals Age and Sex Specific Reference Intervals for Modifiable Risk Factors of Cardiovascular Diseases for Gujarati Asian Indians

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Sibasis Sahoo ◽  
Komal H. Shah ◽  
Ashwati R. Konat ◽  
Kamal H. Sharma ◽  
Payal Tripathi
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Reference Intervals ◽  
Specific Reference ◽  
Cross Sectional ◽  
Female Population ◽  
Mean Values ◽  
Disease Free ◽  
Age And Sex ◽  
Apparently Healthy

Objective. We aimed to establish age and sex specific percentile reference data for cardiovascular risk factors such as lipids, sugar, blood pressure, and BMI in apparently healthy and disease-free Gujarati population.Methods.In this cross-sectional study, we enrolled 3265 apparently healthy and disease-free individuals of both genders residing in Gujarat state. Fasting samples of blood were used for biochemical estimations of lipids and sugar. The measurement of BMI and blood pressure was also done according to the standard guidelines. Age and gender specific 5th, 25th, 50th, 75th, 90th, and 95th percentiles were obtained.Results. The mean values of lipids, sugar, blood pressure, and BMI were significantly (p<0.001) higher in males as compared to female population. Age-wise distribution trends showed increase in the risk factors from the 2nd decade until the 5th to 6th decade in most of the cases, where loss of premenopausal protection in females was also observed. Specific trends according to gender and age were observed in percentile values of various parameters.Conclusion.The outcome of current study will contribute significantly to proposing clinically important reference values of various lipids, sugar, blood pressure, and BMI that could be used to screen the asymptomatic Gujarati Indian population with a propensity of developing dyslipidemia, diabetes, blood pressure, and obesity.

Acquired Ptosis in the Young and Middle-aged Adult Population

Ophthalmology ◽  
1995 ◽  
Vol 102 (6) ◽  
pp. 924-928 ◽  
Author(s):  
Robert C. Kersten ◽  
Carlo de Conciliis ◽  
Dwight R. Kulwin
Keyword(s):  
Adult Population ◽  
Middle Aged ◽  
Middle Aged Adult

Acquired Ptosis in the Young and Middle-Aged Adult Population

1996 ◽  
Vol 16 (1) ◽  
pp. 62
Author(s):  
R C Kersten ◽  
C de Conciliis ◽  
D R Kulwin
Keyword(s):  
Adult Population ◽  
Middle Aged ◽  
Middle Aged Adult
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