Highly sensitive and selective acute myocardial infarction detection using aptamer‐tethered MoS 2 nanoflower and screen‐printed electrodes

2020 ◽  
Author(s):  
Mugashini Vasudevan ◽  
Melvin J.Y. Tai ◽  
Veeradasan Perumal ◽  
Subash C.B. Gopinath ◽  
Satisvar Sundera Murthe ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Screen Printed Electrodes ◽  
Highly Sensitive ◽  
Screen Printed

scholarly journals The value of highly sensitive troponin in the early diagnosis of acute myocardial infarction.

2018 ◽  
Vol 96 (1) ◽  
pp. 25-29
Author(s):  
N. N. Borovkov ◽  
Natalya A. Golitsyna
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Early Diagnosis ◽  
Diagnostic Accuracy ◽  
Clinical Significance ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin ◽  
Sensitivity Specificity

Aim. Study the immediate clinical significance of determination of highly sensitive troponin (high sensitive cardiac troponin - hscTn) in the early diagnosis of acute myocardial infarction (AMI). Material and methods. The analysis of nosological diagnosis in 92 patients with acute coronary syndrome (ACS), urgently hospitalized in the coronary care unit of the Nizhny Novgorod regional hospital. N.A. Semashko. The time from the moment of development of pain syndrome, hospitalization in a hospital ranged from 40 minutes to 4 hours, averaging 2.5 ± 0.32 hours. During hospitalization of patients in the complex diagnosis of AMI in addition to General clinical examination, ECG was determined by the content hscTn and troponin I. All patients in the hospital was performed selective coronary angiography (SCG). Evaluated the sensitivity, specificity and diagnostic accuracy hscTn in comparison with troponin I. Analysis results were represented as a percentage and using a software package "STATISTICA 10.0" (StatSoft, Inc., USA). Results. AMI is diagnosed in 74% of cases (n=68), and the rest 26% (n=24) unstable (progressive) angina (NS). Transmural myocardial infarction or Q-wave myocardial infarction detected in 54% (n=37) of patients. Intramural myocardial infarction or non Q-wave myocardial infarction - in 46% (n=31). AMI re-seen in 27% (n=18). Importance of the study of both cardiac troponin in the early diagnosis of AMI showed the following. Sensitivity hscTn reached 98%, while troponin I - 88%. Specificity hscTn was 79%, and troponin I, only 66%. Overall diagnostic accuracy hscTn was 92%, troponin I less - 83%). Conclusion. The results of the study indicate a predominant clinical significance hscTn in comparison with troponin I in early diagnosis of AMI in the parameters of sensitivity, specificity and diagnostic accuracy.

scholarly journals Development of a Magnetic Nanoparticles-Based Screen-Printed Electrodes (MNPs-SPEs) Biosensor for the Quantification of Ochratoxin A in Cereal and Feed Samples

Toxins ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 317 ◽  
Author(s):  
Xian Zhang ◽  
Zuohuan Wang ◽  
Hui Xie ◽  
Renjie Sun ◽  
Tong Cao ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Ochratoxin A ◽  
Limit Of Detection ◽  
Screen Printed Electrodes ◽  
Combined Use ◽  
Highly Sensitive ◽  
Relative Standard ◽  
Liquid Chromatography Tandem Mass ◽  
Feed Samples ◽  
Screen Printed

A rapid and sensitive electrochemical biosensor based on magnetic nanoparticles and screen-printed electrodes (MNPs-SPEs sensor) was developed for the detection of ochratoxin A (OTA) in cereal and feed samples. Different types of magnetic nanoparticles-based ELISA (MNPs-ELISA) were optimized, and the signal detection, as well as sensitivity, was enhanced by the combined use of screen-printed electrodes (SPEs). Under the optimized conditions, the calibration curve of the MNPs-SPEs sensor was y = 0.3372x + 0.8324 (R2 = 0.9805). The linear range of detection and the detection limit were 0.01–0.82 ng/mL and 0.007 ng/mL, respectively. In addition, 50% inhibition (IC50) was detectable at 0.10 ng/mL. The limit of detection (LOD) of this MNPs-SPEs sensor in cereal and feed samples was 0.28 μg/kg. The recovery rates in spiked samples were between 78.7% and 113.5%, and the relative standard deviations (RSDs) were 3.6–9.8%, with the coefficient of variation lower than 15%. Parallel analysis of commercial samples (corn, wheat, and feedstuff) showed a good correlation between MNPs-SPEs sensor and liquid chromatography tandem mass spectrometry (LC/MS-MS). This new method provides a rapid, highly sensitive, and less time-consuming method to determine levels of ochratoxin A in cereal and feedstuff samples.

scholarly journals COMPARISON OF HIGHLY SENSITIVE TROPONIN I AND T RESULTS IN THE DIAGNOSIS OF ACUTE MYOCARDIAL INFARCTION

2013 ◽  
Vol 61 (10) ◽  
pp. E228 ◽  
Author(s):  
William Parsonage ◽  
Louise Cullen ◽  
Jaimi Greenslade ◽  
Jill Tate ◽  
Jacobus Ungerer ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Troponin I ◽  
Highly Sensitive ◽  
Highly Sensitive Troponin

A Highly Sensitive Non-Enzymatic Urea Sensor Based onNi(OH)2/Mn3O4/rGO/PANi Nanocomposites Using Screen-Printed Electrodes

2021 ◽  
Author(s):  
Saeid Malekinia ◽  
Farshad Kheiri ◽  
Elham Jannatdoust ◽  
Mohammad Sirousazar ◽  
Vahid Abbasi Chianeh
Keyword(s):  
Screen Printed Electrodes ◽  
Highly Sensitive ◽  
Screen Printed

Highly Sensitive and Quick Detection of Acute Myocardial Infarction Biomarkers Using In2O3Nanoribbon Biosensors Fabricated Using Shadow Masks

ACS Nano ◽  
2016 ◽  
Vol 10 (11) ◽  
pp. 10117-10125 ◽  
Author(s):  
Qingzhou Liu ◽  
Noppadol Aroonyadet ◽  
Yan Song ◽  
Xiaoli Wang ◽  
Xuan Cao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Highly Sensitive

Highly Sensitive Immunoassay for the Diagnosis of Acute Myocardial Infarction Using Silica Spheres Encapsulating a Quantum Dot Layer

2014 ◽  
Vol 86 (20) ◽  
pp. 10157-10163 ◽  
Author(s):  
Hyojeong Han ◽  
Jae-Chul Pyun ◽  
Hyein Yoo ◽  
Hong Seog Seo ◽  
Byung Hwa Jung ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Quantum Dot ◽  
Silica Spheres ◽  
Highly Sensitive
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