Sensitive determination of NT‐proBNP for diagnosing abdominal aortic aneurysms incidence on interdigitated electrode sensor

2020 ◽  
Author(s):  
Changcheng Qiu ◽  
Xiao Wang ◽  
Xia Zhang ◽  
Zhenhuan Li ◽  
Yiming Zhou ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Interdigitated Electrode ◽  
Abdominal Aortic ◽  
Electrode Sensor ◽  
Sensitive Determination

Abstract 107: Depletion of Plasmacytoid Dendritic Cells Inhibits Experimental Abdominal Aortic Aneurysms

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Baohui Xu ◽  
Haojun Xuan ◽  
Naoki Fujimura ◽  
Sara A Michie ◽  
Ronald L Dalman
Keyword(s):  
Dendritic Cells ◽  
Inflammatory Diseases ◽  
Myeloid Cells ◽  
Abdominal Aortic Aneurysms ◽  
Plasmacytoid Dendritic Cells ◽  
Aortic Aneurysms ◽  
Major Type ◽  
Abdominal Aortic

Introduction: Abdominal aortic aneurysms (AAA) manifest histologic features consistent with other chronic inflammatory diseases. Infiltrating mural myeloid cells (e.g. macrophages) are already recognized as important contributors to aneurysm pathogenesis, however, the role of plasmacytoid dendritic cells (pDC), major type 1 interferon-producing myeloid cells involving in autoimmune diseases and atherosclerosis, has not been previously investigated in this context. Methods and Results: AAAs were created in 12 week old male C57BL/6J mice by transient intra-aortic infusion of porcine pancreatic elastase (PPE). AAA development and progression were assessed via serial ultrasound determination of aortic diameter in vivo , and histology at sacrifice. The fraction of circulating leukocytes identified as pDCs was significantly increased immediately following PPE infusion (aneurysm initiation). Treatment with mPDCA-1 mAb (400 μg i.p. q.o.d.), beginning one day prior to PPE infusion, depleted more than 90% of bone marrow, spleen and peripheral blood pDCs (data not shown) and suppressed subsequent aneurysm development and progression compared to that noted in PPE-infused mice treated with control mAb. mPDCA-1 treatment promoted aortic medial elastin and smooth muscle preservation, while limiting mural macrophage accumulation and neocapillary formation. Conclusion: These findings suggest a role for plasmacytoid dendritic cells in promoting the initiation and progression of experimental abdominal aortic aneurysms.

COMPARISON OF TWO METHODS FOR ESTIMATING THE UNLOADED STATE FOR ABDOMINAL AORTIC ANEURYSM STRESS CALCULATIONS

2019 ◽  
Vol 19 (03) ◽  
pp. 1950015 ◽  
Author(s):  
JOSEPH R. LEACH ◽  
CHENGCHENG ZHU ◽  
DAVID SALONER ◽  
MICHAEL D. HOPE
Keyword(s):  
Finite Element ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Rupture Risk ◽  
Geometric Accuracy ◽  
Abdominal Aortic ◽  
Unloaded State ◽  
Geometric Scaling

Biomechanical analyses can be used to better understand the rupture risk of abdominal aortic aneurysms (AAAs) on a patient-specific basis using vascular geometries obtained from medical imaging. Methodologies of varying complexity are used to estimate the unloaded state of the imaged vessel to provide a reference configuration for finite element simulations. In this work, we compare the implementation and results of two of these methods, one based on geometric scaling and the other using an iterative determination of unloaded vessel geometry. We find that the two methods result in significantly different stress predictions, and that the iterative method offers superior geometric accuracy. Our findings lend context to the variation in finite element results presented in the AAA stress analysis literature.

Towards A Noninvasive Method for Determination of Patient-Specific Wall Strength Distribution in Abdominal Aortic Aneurysms

2006 ◽  
Vol 34 (7) ◽  
pp. 1098-1106 ◽  
Author(s):  
Jonathan P. Vande Geest ◽  
David H. J. Wang ◽  
Stephen R. Wisniewski ◽  
Michel S. Makaroun ◽  
David A. Vorp
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Strength Distribution ◽  
Aortic Aneurysms ◽  
Patient Specific ◽  
Noninvasive Method ◽  
Wall Strength ◽  
Abdominal Aortic

Abdominal Aortic Aneurysms at Multi–Detector Row Helical CT: Optimization with Interactive Determination of Scanning Delay and Contrast Medium Dose

Radiology ◽  
2004 ◽  
Vol 232 (3) ◽  
pp. 854-859 ◽  
Author(s):  
Lisa M. Ho ◽  
Rendon C. Nelson ◽  
John Thomas ◽  
Edgardo I. Gimenez ◽  
David M. DeLong
Keyword(s):  
Contrast Medium ◽  
Helical Ct ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic ◽  
Medium Dose

Determination of the expansion rate and incidence of ruptur of abdominal aortic aneurysms

1991 ◽  
Vol 14 (4) ◽  
pp. 540-548 ◽  
Author(s):  
David H. Modai ◽  
Raymond H. Limet ◽  
Natzi H. Sakalihassan
Keyword(s):  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Expansion Rate ◽  
Abdominal Aortic

Computed tomography (CT) of abdominal aortic aneurysms: determination of longitudinal extent

1981 ◽  
Vol 68 (1) ◽  
pp. 47-50 ◽  
Author(s):  
A. K. Dixon ◽  
R. G. Springall ◽  
I. Kelsey Fry ◽  
G. W. Taylor
Keyword(s):  
Computed Tomography ◽  
Abdominal Aortic Aneurysms ◽  
Aortic Aneurysms ◽  
Abdominal Aortic
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