Formulation of a pH‐sensitive cancer cell‐targeted gene delivery system based on folate–chitosan conjugated nanoparticles

2020 ◽  
Author(s):  
Reza Mohammadzadeh ◽  
Parinaz Shahim ◽  
Ali Akbari
Keyword(s):  
Gene Delivery ◽  
Cancer Cell ◽  
Delivery System ◽  
Ph Sensitive ◽  
Gene Delivery System ◽  
Targeted Gene Delivery

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 342-343 ◽  
pp. 449-452 ◽  
Author(s):  
Tae Hee Kim ◽  
Hua Jin ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The key strategy for the advancement of gene therapy is the development of an efficient targeted gene delivery system into cells. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relatively low transfection efficiency. It also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency. Also, the potential of clinical application was investigated.

A facile pH-sensitive shielding strategy for polycationic gene delivery system

2017 ◽  
Vol 259 ◽  
pp. e158-e159
Author(s):  
Xiuwen Guan ◽  
Ying Zhang ◽  
Huayu Tian ◽  
Xuesi Chen
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Ph Sensitive ◽  
Gene Delivery System

Receptor-Mediated Gene Delivery Using Chitosan Derivatives In Vitro and In Vivo

2007 ◽  
Vol 539-543 ◽  
pp. 641-646 ◽  
Author(s):  
Tae Hee Kim ◽  
Jin Hua ◽  
Hyun Woo Kim ◽  
Myung Haing Cho ◽  
Jae Woon Nah ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Viral Gene ◽  
Gene Delivery System ◽  
Targeted Gene Delivery ◽  
Cell Specificity ◽  
Selective Delivery

The development of an efficient targeted gene delivery system into cells is an important strategy for the advancement of gene therapy. The targeted gene delivery system is especially important in non-viral gene transfer which shows the relative low transfection efficiency. And it also opens the possibility of selective delivery of therapeutic plasmids to specific tissues. Chitosan has been considered to be a good candidate for gene delivery system, since it is already known as a biocompatible, biodegradable, and low toxic material with high cationic potential. However, low specificity and low transfection efficiency of chitosan need to be overcome prior to clinical trial. In this study, we focused on the chemical modification of chitosan for enhancement of cell specificity and transfection efficiency.

Development of a receptor-targeted gene delivery system using CXCR4 ligand-conjugated cross-linking peptides

2014 ◽  
Vol 16 (11-12) ◽  
pp. 336-351 ◽  
Author(s):  
Anna Egorova ◽  
Maria Bogacheva ◽  
Anastasia Shubina ◽  
Vladislav Baranov ◽  
Anton Kiselev
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Cross Linking ◽  
Gene Delivery System ◽  
Targeted Gene Delivery
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