Protective effect of glycyrrhizic acid on cerebral ischemia/reperfusion injury via inhibiting HMGB1‐mediated TLR4/NF‐κB pathway

2019 ◽  
Vol 66 (6) ◽  
pp. 1024-1030 ◽  
Author(s):  
Sunhong Yan ◽  
Chuanqin Fang ◽  
Lei Cao ◽  
Long Wang ◽  
Jing Du ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Glycyrrhizic Acid ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury

scholarly journals Protective effect of extract of the Camellia japonica L. on cerebral ischemia-reperfusion injury in rats

2019 ◽  
Vol 77 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Weizhuo Lu ◽  
Ling Xv ◽  
Jiyue Wen
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Infarct Volume ◽  
Ischemia Reperfusion ◽  
Camellia Japonica ◽  
Lactate Dehydrogenase Activity ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury

ABSTRACT Objective: We investigated the protective effect of the extract of the Camellia japonica L. flower on cerebral ischemia-reperfusion injury in rats. Methods: The rat ischemia-reperfusion injury was induced by middle cerebral artery occlusion for 90 minutes and reperfusion for 48 hours. The animals received an intravenous injection once a day of 20, 40, 80 mg/kg extract of C. japonica for three consecutive days before the ischemia reperfusion. The learning and memory function, the infarct volume, serum malondialdehyde (MDA) level and lactate dehydrogenase activity, and extravasation of immunoglobulin G (IgG) into cerebral parenchyma were assessed as the cell damage index. Results: Pretreatment with extract of C. japonica markedly reduced the infarct volume, serum malondialdehyde level and lactate dehydrogenase activity, and markedly inhibited the extravasation of IgG. Moreover, pretreatment with extract of C. japonica may also inhibit the learning and memory deficits induced by an ischemia-reperfusion injury. Conclusion: It was concluded that pretreatment with extract of C. japonica has a protective effect on cerebral ischemia-reperfusion injury in rats.

scholarly journals Protective effect of Canna indica on cerebral ischemia-reperfusion injury in rats

2017 ◽  
Vol 51 (6) ◽  
pp. 470-477 ◽  
Author(s):  
Mallikarjuna Rao Talluri ◽  
Kishore Naidu Killari ◽  
N.V.S. Viswanadha Murthy Manepalli ◽  
Prasad Konduri ◽  
Kiran Kumar Bandaru
Keyword(s):  
Cerebral Ischemia ◽  
Protective Effect ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Canna Indica ◽  
Cerebral Ischemia Reperfusion ◽  
Cerebral Ischemia Reperfusion Injury
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