Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells

2015 ◽  
Vol 63 (3) ◽  
pp. 328-333 ◽  
Author(s):  
Hui Li ◽  
Fusheng Zhou ◽  
Wenhui Du ◽  
Jinfa Dou ◽  
Yu Xu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Carcinoma Cells ◽  
Asparagine Synthetase ◽  
Epidermoid Carcinoma ◽  
Human Melanoma Cells

Genistin inhibits UV light-induced plasmid DNA damage and cell growth in human melanoma cells

2006 ◽  
Vol 17 (2) ◽  
pp. 103-108 ◽  
Author(s):  
A RUSSO ◽  
V CARDILE ◽  
L LOMBARDO ◽  
L VANELLA ◽  
R ACQUAVIVA
Keyword(s):  
Dna Damage ◽  
Cell Growth ◽  
Plasmid Dna ◽  
Uv Light ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

scholarly journals Sema6A and Mical1 control cell growth and survival of BRAFV600E human melanoma cells

Oncotarget ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2779-2793 ◽  
Author(s):  
Rossella Loria ◽  
Giulia Bon ◽  
Valentina Perotti ◽  
Enzo Gallo ◽  
Ilaria Bersani ◽  
...  
Keyword(s):  
Cell Growth ◽  
Control Cell ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Growth And Survival ◽  
Human Melanoma Cells ◽  
Cell Growth And Survival

scholarly journals CD40 expressed on human melanoma cells mediates T cell co-stimulation and tumor cell growth

2000 ◽  
Vol 12 (6) ◽  
pp. 787-795 ◽  
Author(s):  
Giuseppe Pirozzi ◽  
Vincenza Lombari ◽  
Delia Zanzi ◽  
Franco Ionna ◽  
Maria Luisa Lombardi ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
Tumor Cell ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Tumor Cell Growth ◽  
Human Melanoma Cells

Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides

2011 ◽  
Vol 102 (12) ◽  
pp. 2139-2149 ◽  
Author(s):  
Maiko Miyata ◽  
Mariko Kambe ◽  
Orie Tajima ◽  
Setsuko Moriya ◽  
Hiromichi Sawaki ◽  
...  
Keyword(s):  
Cell Growth ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells

Lichen metabolites inhibit UV light and nitric oxide-induced plasmid DNA damage and cell growth in human melanoma cells

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
A Russo ◽  
M Piovano ◽  
L Lombardo ◽  
A Vanella ◽  
V Cardile ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Dna Damage ◽  
Cell Growth ◽  
Plasmid Dna ◽  
Uv Light ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Lichen Metabolites

Mitogen-activated protein kinases control p27/Kip1 expression and growth of human melanoma cells

2001 ◽  
Vol 357 (1) ◽  
pp. 297-303 ◽  
Author(s):  
Marcin KORTYLEWSKI ◽  
Peter C. HEINRICH ◽  
Maria-Elisabeth KAUFFMANN ◽  
Markus BÖHM ◽  
Andrzej MACKIEWICZ ◽  
...  
Keyword(s):  
Cell Growth ◽  
Protein Kinases ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Mitogen Activated Protein Kinases ◽  
Mapk Activity ◽  
Human Melanoma Cells ◽  
Mitogen Activated Protein ◽  
P27 Kip1 ◽  
Constitutively Active

The mitogen-activated protein kinases (MAPKs) extracellular signal-regulated protein kinase (ERK)1 and ERK2, involved in regulating cell growth and differentiation, are constitutively active in A375 and WM239 human melanoma cells. Using PD098059, an inhibitor of MAPK kinase (MEK), we investigated the role of persistently activated ERK1/2 in cell growth. The inhibition of MAPK activity induced a dose-dependent growth arrest in G0/G1 phase. Correspondingly, we observed the up-regulation of the cyclin-dependent kinase (Cdk) inhibitor p27/Kip1 and hypophosphorylation of the retinoblastoma protein. Further studies showed that PD098059 treatment significantly decreased Cdk2 kinase activity, most probably owing to an augmented level of p27/Kip1 associated with cyclin E–Cdk2 complexes. The accumulation of p27/Kip1 protein in A375 cells was attributed to its increased stability. Our findings suggest that constitutively active ERK1/2 kinases contribute to the growth of melanoma cells by negative regulation of the p27/Kip1 inhibitor.

Sign in / Sign up

Export Citation Format

Share Document