Comprehensive analysis of PEGylated liposome-associated proteins relating to the accelerated blood clearance phenomenon by combination with shotgun analysis and conventional methods

2014 ◽  
Vol 62 (4) ◽  
pp. 547-555 ◽  
Author(s):  
Munehira Kawanishi ◽  
Yosuke Hashimoto ◽  
Taro Shimizu ◽  
Ikuko Sagawa ◽  
Tatsuhiro Ishida ◽  
...  
Keyword(s):  
Comprehensive Analysis ◽  
Blood Clearance ◽  
Pegylated Liposome ◽  
Associated Proteins ◽  
Conventional Methods ◽  
Accelerated Blood Clearance

Anti-PEG scFv corona ameliorates accelerated blood clearance phenomenon of PEGylated nanomedicines

2021 ◽  
Vol 330 ◽  
pp. 493-501
Author(s):  
Zui Zhang ◽  
Yuxiu Chu ◽  
Cheng Li ◽  
Wenjing Tang ◽  
Jun Qian ◽  
...  
Keyword(s):  
Blood Clearance ◽  
Accelerated Blood Clearance

Accelerated blood clearance and hypersensitivity by PEGylated liposomes containing TLR agonists

2021 ◽  
Author(s):  
Camilla Stavnsbjerg ◽  
Esben Christensen ◽  
Rasmus D. Münter ◽  
Jonas R. Henriksen ◽  
Matthias Fach ◽  
...  
Keyword(s):  
Blood Clearance ◽  
Pegylated Liposomes ◽  
Tlr Agonists ◽  
Accelerated Blood Clearance

scholarly journals Polysialic Acid Modified Liposomes for Improving Pharmacokinetics and Overcoming Accelerated Blood Clearance Phenomenon

Coatings ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 834
Author(s):  
Xi Han ◽  
Ting Zhang ◽  
Mengyang Liu ◽  
Yanzhi Song ◽  
Xinrong Liu ◽  
...  
Keyword(s):  
Blood Circulation ◽  
Polysialic Acid ◽  
Repeated Administration ◽  
The Body ◽  
Circulation Time ◽  
Blood Clearance ◽  
In Vivo Evaluation ◽  
Accelerated Blood Clearance ◽  
Abc Phenomenon

Poly (ethylene glycol) (PEG) modified nanocarriers are being used widely in the drug delivery system (DDS). However, the “accelerated blood clearance (ABC) phenomenon” was induced upon repeated administration of PEG-modified liposomes, resulting in reduced blood circulation time, and increased accumulation in liver and spleen. To avoid the unexpected phenomenon, polysialic acid (PSA) was selected to modify liposomes. PSA is a natural, highly hydrophilic polysaccharide polymer for which no receptors exists in the body. It is non-immunogenic, biodegradable and endows the conjugated bioactive macromolecule and drugs with increased circulation time in vivo. In the present study, the in vivo evaluation showed that PSA modified liposomes (PSA-Lip) afford extended blood circulation in wistar rats and beagle dogs. Moreover, the ABC phenomenon did not occur and the IgM antibody was not induced after repeated injections of PSA-Lip. These results strongly suggest that PSA modification represents a promising strategy to afford good stealth of the liposomes without evoking the ABC phenomenon.

Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles

2012 ◽  
Vol 432 (1-2) ◽  
pp. 75-79 ◽  
Author(s):  
Hiroyuki Koide ◽  
Tomohiro Asai ◽  
Hiroki Kato ◽  
Hidenori Ando ◽  
Kouichi Shiraishi ◽  
...  
Keyword(s):  
Polymeric Micelles ◽  
Blood Clearance ◽  
Size Dependent ◽  
Accelerated Blood Clearance
Sign in / Sign up

Export Citation Format

Share Document