Vitamin D Receptor Polymorphisms Associated with Autism Spectrum Disorder

2020 ◽  
Vol 13 (5) ◽  
pp. 680-690 ◽  
Author(s):  
Franca Rosa Guerini ◽  
Elisabetta Bolognesi ◽  
Matteo Chiappedi ◽  
Maria Martina Mensi ◽  
Oscar Fumagalli ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Polymorphisms in Vitamin D Receptor Genes in Association with Childhood Autism Spectrum Disorder

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Zengyu Zhang ◽  
Sufang Li ◽  
Lianfang Yu ◽  
Jun Liu
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Chinese Population ◽  
Autism Spectrum ◽  
Han Chinese ◽  
Spectrum Disorder ◽  
Taqman Probe ◽  
Vdr Gene ◽  
Han Chinese Population

Both genetic and environmental factors have been implicated in the etiology of autism spectrum disorder (ASD). This case-control study aimed to determine the association of single-nucleotide polymorphisms (SNPs) rs731276 (TaqI), rs1568820 (Cdx2), rs1544410 (BsmI), and rs2228570 (FokI) in the vitamin D receptor (VDR) gene with susceptibility of childhood ASD and severity of the disease. A total of 201 children with ASD and 200 healthy controls from the Han Chinese population were recruited. SNP genotyping was carried out by TaqMan probe-based real-time PCR using genomic DNA extracted from blood cells. Among four examined SNPs, only the CT genotype (odds ratio (OR) = 1.96, 95% confidence interval (CI) = 1.05–3.68,P=0.0351) and the C allele (OR = 1.88, 95% CI = 1.02–3.46,P=0.0416) of the rs731276 were significantly associated with increased risks of childhood ASD. None of the SNPs were associated with severity of childhood ASD. Our results reveal that certain polymorphisms in the VDR gene are a risk factor related to childhood ASD in the Han Chinese population.

Association between vitamin D receptor gene FokI and TaqI variants with autism spectrum disorder predisposition in Iranian population

Gene ◽  
2020 ◽  
Vol 723 ◽  
pp. 144133 ◽  
Author(s):  
Leila Mobasheri ◽  
Seyedeh Zahra Moossavi ◽  
Aliakbar Esmaeili ◽  
Milad Mohammadoo-khorasani ◽  
Gholamreza Anani Sarab
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Iranian Population ◽  
Vitamin D Receptor Gene

scholarly journals Vitamin D and Autism Spectrum Disorder: A Literature Review

Nutrients ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 236 ◽  
Author(s):  
Hajar Mazahery ◽  
Carlos Camargo ◽  
Cathryn Conlon ◽  
Kathryn Beck ◽  
Marlena Kruger ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Literature Review ◽  
Autism Spectrum ◽  
Spectrum Disorder

scholarly journals Rickets treatment improves more than bone health in toddler with autism spectrum disorder: A brief report

2019 ◽  
Vol 7 ◽  
pp. 2050313X1987002 ◽  
Author(s):  
Leah D Stalnaker ◽  
Priya Prasher ◽  
Susan Flesher
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Case Report ◽  
Effective Treatment ◽  
Vitamin D Deficiency ◽  
Developmental Delay ◽  
Bone Health ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorder

Children with autism spectrum disorder have been found to have lower levels of vitamin D than their peers. Our case report supports the hypothesis that vitamin D may be an effective treatment for developmental delay in autism. In addition, we review the literature surrounding vitamin D deficiency as a potential cause of autism spectrum disorder and the role that vitamin D may play in treatment.

Bench to bedside review: Possible role of vitamin D in autism spectrum disorder

2018 ◽  
Vol 260 ◽  
pp. 360-365 ◽  
Author(s):  
Feiyong Jia ◽  
Ling Shan ◽  
Bing Wang ◽  
Honghua Li ◽  
Chunyue Miao ◽  
...  
Keyword(s):  
Autism Spectrum Disorder ◽  
Vitamin D ◽  
Autism Spectrum ◽  
Spectrum Disorder
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