Reduced structural brain asymmetry during neonatal life is potentially related to autism spectrum disorders in children born extremely preterm

2019 ◽  
Vol 12 (9) ◽  
pp. 1334-1343
Author(s):  
Eva Eklöf ◽  
Gustaf E. Mårtensson ◽  
Ulrika ådén ◽  
Nelly Padilla
Author(s):  
Anna Toijonen ◽  
Seppo Heinonen ◽  
Mika Gissler ◽  
Laura Seikku ◽  
Georg Macharey

Abstract Purpose To assess the risk of adverse neurodevelopmental outcomes at the age of four after an attempted vaginal delivery according to the fetal presentation in birth. Methods This retrospective record linkage study evaluated the risks of cerebral palsy, epilepsy, intellectual disability, autism spectrum disorder, attention-deficit/hyperactivity disorder, and speech, visual, and auditory disabilities among preterm children born after an attempted vaginal breech delivery. The control group comprised children born in a cephalic presentation at the same gestational age. This study included 23 803 singleton deliveries at gestational weeks 24 + 0–36 + 6 between 2004 and 2014. Results From 1629 women that underwent a trial of vaginal breech delivery, 1122 (66.3%) were converted to emergency cesarean sections. At extremely preterm and very preterm gestations (weeks 24 + 0—31 + 6), no association between a trial of vaginal breech delivery and neurodevelopmental delay occurred. At gestational weeks 32 + 0—36 + 6, the risks of visual disability (aOR 1.67, CI 1.07—2.60) and autism spectrum disorders (aOR 2.28, CI 1.14—4.56) were increased after an attempted vaginal breech delivery as compared to vaginal cephalic delivery. Conclusion A trial of vaginal breech delivery at extremely preterm and very preterm gestations appears not to increase the risk of adverse neurodevelopmental outcomes at the age of four. In moderate to late preterm births, a trial of vaginal breech delivery was associated with an increased risk of visual impairment and autism spectrum disorders compared to children born in cephalic presentation. A trial of vaginal preterm breech delivery requires distinctive consideration and careful patient selection.


2008 ◽  
Vol 13 (6) ◽  
pp. 614-623 ◽  
Author(s):  
P Hammond ◽  
C Forster-Gibson ◽  
A E Chudley ◽  
J E Allanson ◽  
T J Hutton ◽  
...  

2012 ◽  
Vol 33 (7) ◽  
pp. 535-541 ◽  
Author(s):  
Bonnie E. Stephens ◽  
Carla M. Bann ◽  
Victoria E. Watson ◽  
Stephen J. Sheinkopf ◽  
Myriam Peralta-Carcelen ◽  
...  

2010 ◽  
Vol 156 (4) ◽  
pp. 525-531.e2 ◽  
Author(s):  
Samantha Johnson ◽  
Chris Hollis ◽  
Puja Kochhar ◽  
Enid Hennessy ◽  
Dieter Wolke ◽  
...  

2010 ◽  
Vol 20 (2) ◽  
pp. 42-50 ◽  
Author(s):  
Laura W. Plexico ◽  
Julie E. Cleary ◽  
Ashlynn McAlpine ◽  
Allison M. Plumb

This descriptive study evaluates the speech disfluencies of 8 verbal children between 3 and 5 years of age with autism spectrum disorders (ASD). Speech samples were collected for each child during standardized interactions. Percentage and types of disfluencies observed during speech samples are discussed. Although they did not have a clinical diagnosis of stuttering, all of the young children with ASD in this study produced disfluencies. In addition to stuttering-like disfluencies and other typical disfluencies, the children with ASD also produced atypical disfluencies, which usually are not observed in children with typically developing speech or developmental stuttering. (Yairi & Ambrose, 2005).


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