Water‐soluble Glucosamine‐coated AIE‐Active Fluorescent Organic Nanoparticles: Design, Synthesis and Assembly for Specific Detection of Heparin Based on Carbohydrate–Carbohydrate Interactions

2019 ◽  
Vol 14 (19) ◽  
pp. 3295-3300 ◽  
Author(s):  
Yan‐ming Ji ◽  
Guang‐jian Liu ◽  
Cui‐yun Li ◽  
Yi‐chen Liu ◽  
Min Hou ◽  
...  
Keyword(s):  
Water Soluble ◽  
Specific Detection ◽  
Design Synthesis ◽  
Organic Nanoparticles ◽  
Fluorescent Organic Nanoparticles

Soft fluorescent organic nanodots as nanocarriers for porphyrins

2019 ◽  
Vol 23 (11n12) ◽  
pp. 1463-1469
Author(s):  
Isabelle Sasaki ◽  
Jonathan Daniel ◽  
Sébastien Marais ◽  
Jean-Baptiste Verlhac ◽  
Michel Vaultier ◽  
...  
Keyword(s):  
Water Solubility ◽  
Photophysical Properties ◽  
Blue Emission ◽  
Soret Band ◽  
Water Soluble ◽  
Human Neuroblastoma ◽  
Organic Nanoparticles ◽  
Two Photon Microscopy ◽  
Cell Internalization ◽  
Fluorescent Organic Nanoparticles

Novel fluorescent organic nanoparticles made from citric acid and diethylenetriamine were used as biocompatible and highly water-soluble nanocarriers for hydrophobic tetraphenylporphyrin (TPP). The tetraphenylporphyrin units were covalently attached to the nanoparticles, generating conjugated nanoparticles which retain water solubility and preserve the photophysical properties of monomeric TPP. The conjugated nanoparticles show two distinct fluorescence features: blue emission from the nanoparticle when excited in the near-UV (360 nm) and characteristic far-red emission of the TPP when excited in the visible (Soret band or Q bands). The uptake of the conjugated nanoparticles in live human neuroblastoma cancer cells was evidenced using two-photon microscopy. These experiments demonstrate that the fluorescent organic nanoparticles do act as efficient nanocarriers, allowing cell internalization of hydrophobic porphyrins. These conjugated nanoparticles appear as promising nanotools for theranostic (based on the combination of imaging and monitoring of the nanoparticle fluorescence) and therapeutic (photodynamic therapy by selectively exciting the grafted porphyrin units) modalities.

Sign in / Sign up

Export Citation Format

Share Document