Asymmetric Mannich Reaction of Aryl Methyl Ketones with Cyclic Imines Benzo[e ][1,2,3]oxathiazine 2,2-Dioxides Catalyzed by Cinchona Alkaloid-based Primary Amines

2016 ◽  
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Xiao-Yu Cui ◽  
Hui-Xin Duan ◽  
Yongna Zhang ◽  
You-Qing Wang
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Franz Bracher
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Jack Winnick ◽  
Youzhen Ding ◽  
Lawrence A. Bottomley
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Ajith Kumar

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Sankari Devi Elango ◽  
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Qin Wu

AbstractA series of novel chiral 5-(substituted aryl)-1,3,4-thiadiazole derivatives was synthesized in an enantioselective three-component Mannich reaction using cinchona alkaloid squaramide catalyst with excellent enantioselectivities (up to >99% enantiomeric excess (ee)). The bioassay results showed that these derivatives possessed good to excellent activities against tobacco mosaic virus (TMV).


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