Vascular monosodium urate crystal deposition in gout: a dual‐energy CT and microscopy study of cadaveric donors

2022 ◽  
Author(s):  
Nicola Dalbeth ◽  
Mariam Alhilali ◽  
Peter Riordan ◽  
Ravi Narang ◽  
Ashika Chhana ◽  
...  
Keyword(s):  
Microscopy Study ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Monosodium Urate ◽  
Crystal Deposition ◽  
Urate Crystal ◽  
Cadaveric Donors

scholarly journals Presence of monosodium urate crystal deposition by dual-energy CT in patients with gout treated with allopurinol

2017 ◽  
Vol 77 (3) ◽  
pp. 364-370 ◽  
Author(s):  
Nicola Dalbeth ◽  
Savvas Nicolaou ◽  
Scott Baumgartner ◽  
Jia Hu ◽  
Maple Fung ◽  
...  
Keyword(s):  
Severe Disease ◽  
Serum Urate ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Monosodium Urate ◽  
Crystal Deposition ◽  
Patient Global Impression ◽  
The Usa ◽  
Urate Crystal ◽  
Crystal Volume

ObjectiveDual-energy CT (DECT) detects and quantifies monosodium urate (MSU) crystal deposition with high precision. This DECT study assessed crystal deposition in patients with gout treated with stable-dose allopurinol, and investigated potential clinical determinants for crystal deposition.MethodsPatients with gout treated with allopurinol ≥300 mg daily for at least 3 months were prospectively recruited from the USA and New Zealand, using monitored enrolment to include approximately 25% patients with palpable tophi and approximately 50% with serum urate (sUA) levels <6.0 mg/dL (<357µmol/L). MSU crystal deposition was measured in the hands/wrists, feet/ankles/Achilles and knees bilaterally. The presence and total volume of crystals were assessed by DECT and analysed according to sUA levels and gout characteristics.ResultsAmong 152 patients receiving allopurinol ≥300 mg/day for 5.1 years on average, 69.1% had crystal deposition on DECT, with a median total crystal volume of 0.16 cm3 (range: 0.01–19.53 cm3). The prevalence of crystal deposition ranged from 46.9% among patients with sUA <6.0 mg/dL and no palpable tophi to 90.0% among those with sUA ≥6.0 mg/dL and tophi. Total volume of crystal deposition was positively associated with sUA ≥6.0 mg/dL, gout flares within the past 3 months and tophi. Total volume of crystal deposition correlated positively with Patient Global Impression of Disease Activity scores.ConclusionA substantial proportion of patients without palpable tophi have MSU crystal deposition, despite receiving allopurinol doses ≥300 mg/day for a considerable duration. Patients with higher sUA and clinical features of severe disease have a higher frequency and greater volume of MSU crystal deposition.

scholarly journals Urate crystal deposition in hyperuricemic children: a dual energy computed tomography study

2021 ◽  
Vol 17 (1) ◽  
pp. 100-105
Author(s):  
Qianqian Ying ◽  
Jiapei Wang ◽  
Yunyan Li ◽  
Nan Sun ◽  
Yazhen Di ◽  
...  
Keyword(s):  
Rapid Onset ◽  
Dual Energy ◽  
Dual Energy Ct ◽  
Coastal Regions ◽  
Intense Pain ◽  
Asymptomatic Group ◽  
Crystal Deposition ◽  
History Of ◽  
Urate Crystal ◽  
Joint Group

IntroductionThe incidence of hyperuricemia (HUA) at younger ages is increasing along the coastal regions of China. This study aimed to compare the frequency of dual energy CT (DECT) urate crystal deposition between symptomatic hyperuricemic children and asymptomatic hyperuricemic children.Material and methodsFifty-six hyperuricemic children were divided into a Joint Group (n = 33) and an Asymptomatic Group (n = 23) according to whether they had a history of arthritis symptoms, which includes rapid onset monoarthritis with intense pain and swelling. We analyzed DECT scans of their feet from the Joint Group and the Asymptomatic Group and compared their clinical features.ResultsDECT urate deposits were observed in 28/33 (84.8%) children with symptomatic HUA and 14/23 (60.9%) with asymptomatic HUA. We found 60 areas of urate deposition in the Joint Group; DECT urate crystal deposition was most frequently observed in the first metatarsophalangeal (MTP) joint (30.0%), ankle joint (15.0%), and calcaneus (13.3%). 39 urate deposits were found in the Asymptomatic Group; DECT urate crystal deposition was most frequently observed in the calcaneus (25.6%), the first MTP joint (17.9%), and the first phalanx (15.4%).ConclusionsUrate deposition can occur in children with HUA, and these deposits occur more frequently in hyperuricemic children with a history of arthritis symptoms. Also, the urate deposition in the first MTP joint and calcaneus was more prevalent than in other joints. It is important to give more attention to hyperuricemic children.

Monosodium Urate Crystal Deposition in Coronary Artery Plaque by 128-Slice Dual-Energy Computed Tomography

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Gudrun M. Feuchtner ◽  
Fabian Plank ◽  
Christoph Beyer ◽  
Christoph Schwabl ◽  
Julia Held ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Coronary Artery ◽  
Dual Energy ◽  
Monosodium Urate ◽  
Crystal Deposition ◽  
Coronary Artery Plaque ◽  
Dual Energy Computed Tomography ◽  
Urate Crystal

Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study

2015 ◽  
Vol 74 (5) ◽  
pp. 908-911 ◽  
Author(s):  
Nicola Dalbeth ◽  
Meaghan E House ◽  
Opetaia Aati ◽  
Paul Tan ◽  
Christopher Franklin ◽  
...  
Keyword(s):  
Dual Energy ◽  
Dual Energy Ct ◽  
Crystal Deposition ◽  
Urate Crystal
Sign in / Sign up

Export Citation Format

Share Document