scholarly journals Semaphorin3B plays a central role in serum‐induced arthritis model and is reduced in patients with rheumatoid arthritis

2022 ◽  
Author(s):  
Ana Igea ◽  
Tiago Carvalheiro ◽  
Beatriz Malvar‐Fernández ◽  
Sara Martinez‐Ramos ◽  
Carlos Rafael‐Vidal ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Arthritis Model

scholarly journals Simultaneous Determination of 5 Active Components of Periploca forrestii Schltr Extract in Rat Plasma by UPLC-MS and Its Application to Pharmacokinetic Studies in Normal and Adjuvant-Induced Arthritis Model Rats

2020 ◽  
Vol 15 (12) ◽  
pp. 1934578X2098143
Author(s):  
Hui Liu ◽  
Hao Chen ◽  
Xiaoli Qin ◽  
Xue Ma ◽  
Zipeng Gong ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Chlorogenic Acid ◽  
Intravenous Administration ◽  
Area Under The Curve ◽  
Pharmacokinetic Studies ◽  
Active Components ◽  
Arthritis Model ◽  
Adjuvant Induced Arthritis ◽  
Neochlorogenic Acid

Periploca forrestii Schltr ( P. forrestii) is a herb used in traditional Chinese medicine for its anti-rheumatoid arthritis effect. The aim of this study was to compare the pharmacokinetic properties of the 5 active components of this plant: neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid C, and periplocin between normal rats and adjuvant-induced arthritis model rats. After the intravenous administration (177.78 mg/kg) of P. forrestii extract, samples were analyzed by ultra-performance liquid chromatography-tandem mass spectrometry. Compared with normal rats, the area under the curve [(AUC)(0-t), AUC(0-∞)], mean residence time [(MRT)(0-t), MRT(0-∞)] of neochlorogenic acid-treated rats decreased significantly, and drug clearance (CL) and apparent volume of distribution (V) increased significantly; the V of chlorogenic acid-treated rats decreased significantly, and MRT(0-t) significantly increased; the AUC(0-t) and AUC(0-∞) of cryptochlorogenic acid-treated rats decreased significantly, and CL and V increased significantly; the AUC(0-t) and MRT(0-t) of isochlorogenic acid C-treated rats decreased significantly, and V increased significantly; the AUC(0-t) and AUC(0-∞) of periplocin-treated rats increased significantly, and MRT(0-t), MRT(0-∞), CL, and V decreased significantly in model rats. The disease condition of rheumatoid arthritis in rats had a significant effect on the in vivo pharmacokinetics of P. forrestii after the intravenous administration.

Photodynamic Synovectomy Using Benzoporphyrin Derivative in an Antigen-induced Arthritis Model for Rheumatoid Arthritis

1998 ◽  
Vol 67 (1) ◽  
pp. 133-139 ◽  
Author(s):  
Kenneth B. Trauner ◽  
Regina Gandour-Edwards ◽  
Mike Bamberg ◽  
Sonya Shortkroff ◽  
Clement Sledge ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Arthritis Model

AB0113 Dynamics of Macrophage Activation in Rat Lumbar Ganglia of Rheumatoid Arthritis Model

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 841.2-841
Author(s):  
B. Mádrová ◽  
P. Dubový ◽  
I. Klusáková ◽  
V. Brázda
Keyword(s):  
Rheumatoid Arthritis ◽  
Macrophage Activation ◽  
Arthritis Model
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