Correspondence on “Time‐dependent Analysis of Risk of New‐onset Heart Failure among Patients with Polymyositis and Dermatomyositis”

2021 ◽  
Author(s):  
Renin Chang ◽  
Yao‐Min Hung ◽  
James Cheng‐Chung Wei
Keyword(s):  
Heart Failure ◽  
Time Dependent ◽  
Time Dependent Analysis ◽  
New Onset

Time‐dependent Analysis of Risk of New‐onset Heart Failure among Patients with Polymyositis and Dermatomyositis

2021 ◽  
Author(s):  
Chun‐Yu Lin ◽  
Hung‐An Chen ◽  
Tsai‐Ching Hsu ◽  
Chun‐Hsin Wu ◽  
Yu‐Jih Su ◽  
...  
Keyword(s):  
Heart Failure ◽  
Time Dependent ◽  
Time Dependent Analysis ◽  
New Onset

Applications of Time-Dependent Analysis in the Design of Hybrid Bridge Structures

PCI Journal ◽  
2001 ◽  
Vol 46 (4) ◽  
pp. 56-74 ◽  
Author(s):  
Jiri Strasky ◽  
Jaroslav Navratil ◽  
Stanislav Susky
Keyword(s):  
Time Dependent ◽  
Hybrid Bridge ◽  
Bridge Structures ◽  
Time Dependent Analysis

New-onset type 2 diabetes in heart failure: impact of heart failure and death versus ischemic events – a Danish nationwide cohort study

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
B Zareini ◽  
P.B Blanche ◽  
A.H Holt ◽  
M.M Malik ◽  
D.P Rajan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Type 2 Diabetes ◽  
Risk Ratio ◽  
Real Life ◽  
Ischemic Event ◽  
Increased Risk ◽  
The Absolute ◽  
Ischemic Events ◽  
New Onset

Abstract Background Development of type 2 diabetes (T2D) is common in patients with heart failure (HF), but knowledge of future cardiovascular events is lacking. Purpose We compared risk of heart failure hospitalization (HFH) or death versus ischemic events in real-life HF patients with new-onset T2D, prevalent T2D and no T2D. Methods Using the Danish nationwide registers, we identified all patients with HF between 1998–2016. The patients were separated in two different HF cohorts based on the status of T2D. One cohort consisted of HF patients with either prevalent or absent T2D at the time of HF diagnosis. The other cohort consisted of HF patients, who developed new-onset T2D, included at time of diagnosis. The two HF cohorts were analyzed separately. Outcomes for both cohorts were analyzed as time-to-first event as either an ischemic event (i.e. composite outcome of fatal and non-fatal myocardial infarction, stroke, and peripheral artery disease), HFH, or event-free death (not related to HFH or the ischemic event). For each cohort, we estimated the five-year absolute risk of ischemic event, HFH and event-free death, along with five-year risk ratio of HFH or event-free death versus ischemic events. Effects among subgroups were investigated by stratifying both cohorts based on age, gender and comorbidities present at inclusion. Results A total of 139,264 HF patients were included between 1998 and 2016, of which 29,078 (21%) patients had prevalent T2D at baseline. A total of 11,819 (8%) developed new-onset T2D and were included in the second cohort. The median duration of time between HF diagnosis and new-onset T2D diagnosis was: 4.1 years (IQR:1.5; 5.8). The absolute five-year risk of an ischemic event in patients with new-onset T2D, prevalent T2D and no T2D was: 17.9% (95% confidence interval (CI): 17.2; 18.6), 26.1% (95% CI: 25.6; 26.7), and 18.8% (95% CI:18.6; 19.0). Corresponding estimates for HFH were: 31.5% (95% CI: 30.6; 32.3), 33.6% (95% CI: 33.0; 34.2), and 30,7% (95% CI: 30.5; 31.0). The absolute five-year risk of event-free death among patients with new-onset T2D, prevalent T2D and no T2D was: 20.9% (95% CI: 20.2; 21.7), 18.9% (95% CI:18.4; 19.3), and 18.6% (95% CI: 18.4; 18.8) (see Figure). The five-year risk ratio of experiencing HFH or event-free death versus an ischemic event was: 2.9 (95% CI: 2.8; 3.1), 2.0 (95% CI:2.0; 2.1), and 2.6 (95% CI: 2.6; 2.7) for patients with new-onset T2D, prevalent T2D and no T2D, respectively. Similar results of absolute and relative risk were present across all subgroups. Conclusion In our population of HF patients, 8% developed new-onset diabetes. Development of T2D in patients with HF increases the risk of HFH and mortality three-fold. The increased risk of new-onset T2D is higher than the importance of prevalent T2D in patients with HF. Funding Acknowledgement Type of funding source: None

scholarly journals The time-dependent angular analysis of Bd → KSℓℓ, a new benchmark for new physics

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Sébastien Descotes-Genon ◽  
Martín Novoa-Brunet ◽  
K. Keri Vos
Keyword(s):  
Time Evolution ◽  
Form Factors ◽  
New Physics ◽  
Time Dependent ◽  
Angular Analysis ◽  
Time Dependent Analysis ◽  
Tensor Operators

Abstract We consider the time-dependent analysis of Bd→ KSℓℓ taking into account the time-evolution of the Bd meson and its mixing into $$ {\overline{B}}_d $$ B ¯ d . We discuss the angular conventions required to define the angular observables in a transparent way with respect to CP conjugation. The inclusion of time evolution allows us to identify six new observables, out of which three could be accessed from a time-dependent tagged analysis. We also show that these observables could be obtained by time-integrated measurements in a hadronic environment if flavour tagging is available. We provide simple and precise predictions for these observables in the SM and in NP models with real contributions to SM and chirally flipped operators, which are independent of form factors and charm-loop contributions. As such, these observables provide robust and powerful cross-checks of the New Physics scenarios currently favoured by global fits to b → sℓℓ data. In addition, we discuss the sensitivity of these observables with respect to NP scenarios involving scalar and tensor operators, or CP-violating phases. We illustrate how these new observables can provide a benchmark to discriminate among the various NP scenarios in b → sμμ. We discuss the extension of these results for Bs decays into f0, η or η′.

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