scholarly journals Sputum Neutrophil Extracellular Trap Subsets Associate with IgA Anti‐Citrullinated Protein Antibodies in Subjects At‐Risk for Rheumatoid Arthritis

2021 ◽  
Author(s):  
Yuko Okamoto ◽  
Stephanie Devoe ◽  
Nickie Seto ◽  
Valerie Minarchick ◽  
Timothy Wilson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Neutrophil Extracellular Trap ◽  
Extracellular Trap ◽  
Citrullinated Protein

scholarly journals Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

2021 ◽  
Author(s):  
Mihnea R. Mangalea ◽  
David Paez-Espino ◽  
Kristopher Kieft ◽  
Anushila Chatterjee ◽  
Jennifer A. Seifert ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Autoimmune Disease ◽  
Intestinal Microbiota ◽  
Disease Development ◽  
Metabolic Potential ◽  
Metabolic Genes ◽  
Auxiliary Metabolic Genes ◽  
Citrullinated Protein ◽  
Insight Into

SUMMARYRheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first degree relatives have been diagnosed with RA. We show that at-risk individuals harbor intestinal phage compositions that diverge based on CCP serology, are dominated by Lachnospiraceae phages, and originate from disparate ecosystems. These phages encode unique repertoires of auxiliary metabolic genes (AMGs) which associate with anti-CCP status, suggesting that these phages directly influence the metabolic and immunomodulatory capability of the microbiota. This work sets the stage for the use of phages as preclinical biomarkers and provides insight into a possible microbial-based causation of RA disease development.

AB0178 Menopause Is A Predictor for The Development of Anti-Citrullinated Protein Antibodies in Women at Risk for Rheumatoid Arthritis

2016 ◽  
Vol 75 (Suppl 2) ◽  
pp. 957.2-958
Author(s):  
D. Alpizar-Rodriguez ◽  
R. Müller ◽  
B. Möller ◽  
J. Dudler ◽  
A. Ciurea ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Citrullinated Protein

scholarly journals A2.8 Enhanced Neutrophil Extracellular Trap Formation in Rheumatoid Arthritis Patients is Correlated with High Levels of Rheumatoid Factor (RF)

2013 ◽  
Vol 72 (Suppl 1) ◽  
pp. A7.1-A7
Author(s):  
Garyfalia Papadaki ◽  
Christiana Choulaki ◽  
George Bertsias ◽  
Ioannis Mitroulis ◽  
Panayotis Verginis ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Neutrophil Extracellular Trap ◽  
Trap Formation ◽  
Extracellular Trap

scholarly journals Female hormonal factors and the development of anti-citrullinated protein antibodies in women at risk of rheumatoid arthritis

Rheumatology ◽  
2017 ◽  
Vol 56 (9) ◽  
pp. 1579-1585 ◽  
Author(s):  
Deshiré Alpizar-Rodriguez ◽  
Rüdiger B. Mueller ◽  
Burkhard Möller ◽  
Jean Dudler ◽  
Adrian Ciurea ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Hormonal Factors ◽  
Citrullinated Protein

scholarly journals Should We Be Screening for and Treating Periodontal Disease in Individuals Who Are at Risk of Rheumatoid Arthritis?

Healthcare ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1326
Author(s):  
Zhain Mustufvi ◽  
Stefan Serban ◽  
James Chesterman ◽  
Kulveer Mankia
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Periodontal Disease ◽  
Disease Activity ◽  
Joint Inflammation ◽  
Disease Association ◽  
Musculoskeletal Symptoms ◽  
Future Research ◽  
Periodontal Inflammation ◽  
Citrullinated Protein

There is increasing evidence supporting an association between periodontal disease (PD) and rheumatoid arthritis (RA), both mechanistically and clinically. Trials have shown that treating PD in people with RA may improve RA disease activity. Patients with musculoskeletal symptoms without arthritis, who test positive for cyclic-citrullinated protein antibodies, are at risk of RA (CCP+ at-risk), with seropositivity preceding arthritis onset by months or years. Importantly, there is evidence to suggest that periodontal inflammation may precede joint inflammation in CCP+ at-risk and, therefore, this could be a trigger for RA. There has been increased research interest in RA prevention and the phenotyping of the pre-RA disease phase. This review will examine the merits of identifying individuals who are CCP+ at-risk and performing screening for PD. In addition, we discuss how PD should be treated once identified. Finally, the review will consider future research needed to advance our understanding of this disease association.

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