Improved disease course associated with early initiation of biologics in untreated polyarticular Juvenile Idiopathic Arthritis: A trajectory analysis of the STOP‐JIA study

2021 ◽  
Author(s):  
Mei Sing Ong ◽  
Sarah Ringold ◽  
Yukiko Kimura ◽  
Laura E. Schanberg ◽  
George A. Tomlinson ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Trajectory Analysis ◽  
Early Initiation ◽  
Disease Course ◽  
Polyarticular Juvenile Idiopathic Arthritis

Clinically Inactive Disease in a Cohort of Children with New-onset Polyarticular Juvenile Idiopathic Arthritis Treated with Early Aggressive Therapy: Time to Achievement, Total Duration, and Predictors

2014 ◽  
Vol 41 (6) ◽  
pp. 1163-1170 ◽  
Author(s):  
Carol A. Wallace ◽  
Edward H. Giannini ◽  
Steven J. Spalding ◽  
Philip J. Hashkes ◽  
Kathleen M. O’Neil ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Total Duration ◽  
Inactive Disease ◽  
Disease Course ◽  
Polyarticular Juvenile Idiopathic Arthritis ◽  
Open Label ◽  
Aggressive Therapy ◽  
Recent Onset ◽  
American College Of Rheumatology ◽  
Definition Of

Objective.To determine the elapsed time while receiving aggressive therapy to the first observation of clinically inactive disease (CID), total duration of CID and potential predictors of this response in a cohort of children with recent onset of polyarticular juvenile idiopathic arthritis (poly-JIA).Methods.Eighty-five children were randomized blindly to methotrexate (MTX), etanercept, and rapidly tapered prednisolone (MEP) or MTX monotherapy and assessed for CID over 1 year of treatment. Patients who failed to achieve intermediary endpoints were switched to open-label MEP treatment.Results.Fifty-eight (68.2%) of the 85 patients achieved CID at 1 or more visits including 18 who received blinded MEP, 11 while receiving MTX monotherapy, and 29 while receiving open-label MEP. Patients starting on MEP achieved CID earlier and had more study days in CID compared to those starting MTX, but the differences were not significantly different. Patients given MEP (more aggressive therapy) earlier in the disease course were statistically more likely to have a higher proportion of followup visits in CID than those with longer disease course at baseline. Those who achieved American College of Rheumatology Pediatric 70 response at 4 months had a significantly greater proportion of followup visits in CID, compared to those who failed to achieve this improvement (p < 0.0001). Of the 32 patients who met criteria for CID and then lost CID status, only 3 fulfilled the definition of disease flare.Conclusion.Shorter disease duration prior to treatment, a robust response at 4 months, and more aggressive therapy result in a higher likelihood and longer duration of CID in patients with poly-JIA. The original trial from which data for this analysis were obtained is registered on www.clinicaltrials.gov NCT 00443430.

scholarly journals Hip osteoarthritis in juvenile idiopathic arthritis is complication of the disease course or side effect of systemic glucocorticosteroid treatment?

Bone Reports ◽  
2021 ◽  
Vol 14 ◽  
pp. 100940
Author(s):  
Lubov Sorokina ◽  
Ilia Avrusin ◽  
Rinat Raupov ◽  
Sergey Khrypov ◽  
Mikhail Kostik
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Side Effect ◽  
Hip Osteoarthritis ◽  
Disease Course

scholarly journals Lipopolysaccharide stimulation test on cultured PBMCs assists the discrimination of cryopyrin-associated periodic syndrome from systemic juvenile idiopathic arthritis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chao-Yi Wu ◽  
Wen-Lang Fan ◽  
Ying-Ming Chiu ◽  
Huang-Yu Yang ◽  
Wen-I. Lee ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Inflammatory Cytokines ◽  
Mononuclear Cells ◽  
Systemic Juvenile Idiopathic Arthritis ◽  
Periodic Syndrome ◽  
Disease Course ◽  
Peripheral Blood Mononuclear ◽  
Persistent Disease ◽  
Caspase 1 ◽  
Stimulation Tests

AbstractSystemic juvenile idiopathic arthritis (sJIA) and cryopyrin-associated periodic syndrome (CAPS) share many common manifestations. We aim to identify an applicable method to assist disease discrimination. Inflammatory cytokines were measured in the plasma of patients with CAPS, sJIA with persistent disease course and healthy controls. Supernatants collected from non-stimulated peripheral blood mononuclear cells (PBMCs) and those undergone inflammasome stimulation tests utilizing lipopolysaccharide (LPS) with and without adenosine triphosphate (ATP) were investigated. Inflammatory cytokines in patient plasma fail to differentiate sJIA from CAPS. PBMCs from sJIA secrets higher amount of IL-1β and IL-18 while CAPS PBMCs produces more caspase-1 without stimulation. IL-1β, IL-18, and caspase-1 were significantly elevated among CAPS PBMCs (all p < 0.05) upon LPS stimulation, but not when additional ATPs were provided. Levels of cytokines and PBMC responses to the stimulation assays were similar among all sJIA patients regardless of their history of macrophage activation syndrome. Unstimulated PBMC activities and the LPS inflammasome stimulation assay without exogenic ATPs can assist the differentiation of CAPS from sJIA with persistent disease course.

scholarly journals Evaluation of the disease course of Italian children with juvenile idiopathic arthritis treated with etanercept: preliminary results in 772 patients

2014 ◽  
Vol 12 (Suppl 1) ◽  
pp. P130
Author(s):  
Sara Verazza ◽  
Alessandro Consolaro ◽  
Cristina Robbiano ◽  
Antonella Insalaco ◽  
Rolando Cimaz ◽  
...  
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Disease Course ◽  
Preliminary Results ◽  
Italian Children
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