Erosive Hand Osteoarthritis: Incidence and Predictive Characteristics among Participants in the Osteoarthritis Initiative

2021 ◽  
Author(s):  
Timothy E. McAlindon ◽  
Jeffrey B. Driban ◽  
Mary B. Roberts ◽  
Jeffrey Duryea ◽  
Ida K. Haugen ◽  
...  
Keyword(s):  
Hand Osteoarthritis ◽  
Erosive Hand Osteoarthritis ◽  
Osteoarthritis Initiative

Metabolic Syndrome and Osteoarthritis Distribution in the Hand Joints: A Propensity-Score Matched Analysis from Osteoarthritis Initiative

2021 ◽  
pp. jrheum.210189
Author(s):  
Bahram Mohajer ◽  
Robert Kwee ◽  
Ali Guermazi ◽  
Francis Berenbaum ◽  
Mei Wan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Propensity Score ◽  
International Diabetes Federation ◽  
Hand Osteoarthritis ◽  
Cox Regression Analysis ◽  
Hand Pain ◽  
Hand Joints ◽  
The Metabolic Syndrome ◽  
Osteoarthritis Initiative

Objective To investigate the metabolic syndrome (MetS) association with radiographic and symptomatic hand osteoarthritis (OA). Methods Using 1:2 propensity-score-matching for relevant confounders, we included 2509 (MetS+896: MetS–1613) participants from the Osteoarthritis Initiative dataset. MetS and its components, according to the International Diabetes Federation criteria, were extracted from baseline data, including hypertension, abdominal obesity, dyslipidemia, and diabetes. We scored distinct hand joints based on modified Kellgren–Lawrence grade (mKL) of baseline radiographs, with OA defined as mKL≥2. In the cross-sectional analysis, we investigated the association between MetS and its components with radiographic hand OA and the presence of nodal and erosive OA phenotypes using regression models. In the longitudinal analysis, we performed Cox regression analysis for hand pain incidence in follow-up visits. Results MetS was associated with higher odds of radiographic hand OA, including the number of joints with OA (odds ratio, 95%confidence interval:1.32, 1.08–1.62), the sum of joints mKLs (2.42, 1.24–4.71), mainly in distal and proximal interphalangeal joints (DIPs:1.52, 1.08–2.14, PIPs:1.38, 1.09–1.75), but not metacarpophalangeal (MCP) and first carpometacarpal (CMC1) joints. Hand pain incidence during follow-up was higher with MetS presence (hazard ratio, 95%CI:1.25, 1.07–1.47). Erosive hand OA phenotype and joints' nodal involvement were more frequent with MetS (1.40, 1.01–1.97, and 1.28, 1.02–1.60). Conclusion MetS, a potentially modifiable risk factor, is associated with radiographic DIP and PIP OA and longitudinal hand pain incidence while sparing MCPs and CMC1. Nodal and erosive OA phenotypes are associated with MetS, suggestive of possible distinct pathophysiology.

scholarly journals 275 CLINICAL ASPECTS OF EROSIVE HAND OSTEOARTHRITIS

2009 ◽  
Vol 17 ◽  
pp. S150
Author(s):  
J. Bijsterbosch ◽  
I. Watt ◽  
I. Meulenbelt ◽  
F.R. Rosendaal ◽  
T.W. Huizinga ◽  
...  
Keyword(s):  
Clinical Aspects ◽  
Hand Osteoarthritis ◽  
Erosive Hand Osteoarthritis

scholarly journals Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Tereza Kropáčková ◽  
Olga Šléglová ◽  
Olga Růžičková ◽  
Jiří Vencovský ◽  
Karel Pavelka ◽  
...  
Keyword(s):  
Hand Osteoarthritis ◽  
Lower Serum ◽  
Erosive Hand Osteoarthritis

scholarly journals Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234972
Author(s):  
Edem Allado ◽  
Ruth Wittoek ◽  
Stephanie Ferrero ◽  
Eliane Albuisson ◽  
Isabelle Chary-Valckenaere ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hand Osteoarthritis ◽  
Bone Marrow Lesions ◽  
Erosive Hand Osteoarthritis

scholarly journals The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study

2012 ◽  
Vol 71 (10) ◽  
pp. 1698-1701 ◽  
Author(s):  
Ida Kristin Haugen ◽  
David T Felson ◽  
Martin Englund ◽  
Ke Wang ◽  
Piran Aliabadi ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Hand Osteoarthritis ◽  
Erosive Hand Osteoarthritis
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