scholarly journals Familial clustering of erosive hand osteoarthritis in a large statewide cohort

2020 ◽  
Author(s):  
Nikolas H. Kazmers ◽  
Huong D. Meeks ◽  
Kendra A. Novak ◽  
Zhe Yu ◽  
Gail L. Fulde ◽  
...  
Keyword(s):  
Hand Osteoarthritis ◽  
Familial Clustering ◽  
Erosive Hand Osteoarthritis

scholarly journals Familial clustering of erosive hand osteoarthritis in a large statewide cohort

2020 ◽  
Author(s):  
Nikolas H. Kazmers ◽  
Huong D. Meeks ◽  
Kendra A. Novak ◽  
Zhe Yu ◽  
Gail L. Fulde ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
High Risk ◽  
Regression Models ◽  
Conditional Logistic Regression ◽  
Hand Osteoarthritis ◽  
Genetic Contribution ◽  
Familial Clustering ◽  
Erosive Hand Osteoarthritis ◽  
High Risk Families

AbstractObjectivesErosive hand osteoarthritis (EOA) is a severe and rapidly progressing form of osteoarthritis. Its etiology remains largely unknown, which has hindered development of successful treatments. Our primary goal was to test the hypothesis that EOA would demonstrate familial clustering in a large statewide population linked to genealogical records, which would suggest a genetic contribution to the pathogenesis of this condition. Our secondary purpose was to determine the association of potential risk factors with EOA.MethodsPatients diagnosed with EOA were identified by searching medical records from a comprehensive statewide database, the Utah Population Database (UPDB). Affected individuals were then mapped to pedigrees to identify high-risk families with excess clustering of EOA as defined by a Familial Standardized Incidence Ratio (FSIR) of ≥ 2.0. The magnitude of familial risk of EOA in related individuals was calculated using Cox regression models. Association of potential EOA risk factors was analyzed using conditional logistic regression and logistic regression models.ResultsWe identified 703 affected individuals linked to 240 unrelated high-risk pedigrees with excess clustering of EOA (FSIR ≥ 2.0). The relative risk of developing EOA was significantly elevated in first-degree relatives. There was a significant association with the diagnosis of EOA and age, sex, diabetes, and obesity.ConclusionsFamilial clustering of EOA observed in a statewide database indicates a potential genetic contribution to the etiology of the disease. Identification of causal gene variants in these high-risk families may provide insight into the genes and pathways that contribute to EOA onset and progression.

scholarly journals 275 CLINICAL ASPECTS OF EROSIVE HAND OSTEOARTHRITIS

2009 ◽  
Vol 17 ◽  
pp. S150
Author(s):  
J. Bijsterbosch ◽  
I. Watt ◽  
I. Meulenbelt ◽  
F.R. Rosendaal ◽  
T.W. Huizinga ◽  
...  
Keyword(s):  
Clinical Aspects ◽  
Hand Osteoarthritis ◽  
Erosive Hand Osteoarthritis

scholarly journals Lower serum clusterin levels in patients with erosive hand osteoarthritis are associated with more pain

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Tereza Kropáčková ◽  
Olga Šléglová ◽  
Olga Růžičková ◽  
Jiří Vencovský ◽  
Karel Pavelka ◽  
...  
Keyword(s):  
Hand Osteoarthritis ◽  
Lower Serum ◽  
Erosive Hand Osteoarthritis

scholarly journals Assessment of structural lesions, synovitis and bone marrow lesions in erosive hand osteoarthritis on MRI (0.3T) compared to the radiographic anatomical Verbruggen-Veys score

PLoS ONE ◽  
2020 ◽  
Vol 15 (6) ◽  
pp. e0234972
Author(s):  
Edem Allado ◽  
Ruth Wittoek ◽  
Stephanie Ferrero ◽  
Eliane Albuisson ◽  
Isabelle Chary-Valckenaere ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Hand Osteoarthritis ◽  
Bone Marrow Lesions ◽  
Erosive Hand Osteoarthritis

scholarly journals The association between erosive hand osteoarthritis and subchondral bone attrition of the knee: the Framingham Osteoarthritis Study

2012 ◽  
Vol 71 (10) ◽  
pp. 1698-1701 ◽  
Author(s):  
Ida Kristin Haugen ◽  
David T Felson ◽  
Martin Englund ◽  
Ke Wang ◽  
Piran Aliabadi ◽  
...  
Keyword(s):  
Subchondral Bone ◽  
Hand Osteoarthritis ◽  
Erosive Hand Osteoarthritis
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