scholarly journals Autoantibodies to Malondialdehyde–Acetaldehyde Are Detected Prior to Rheumatoid Arthritis Diagnosis and After Other Disease Specific Autoantibodies

2020 ◽  
Vol 72 (12) ◽  
pp. 2025-2029
Author(s):  
Ted R. Mikuls ◽  
Jess Edison ◽  
Elizabeth Meeshaw ◽  
Harlan Sayles ◽  
Bryant R. England ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Diagnosis ◽  
Disease Specific

Diabetes at the time of rheumatoid arthritis diagnosis is an independent predictor of pejorative outcomes: Data from the early arthritis ESPOIR cohort

2018 ◽  
Vol 85 (6) ◽  
pp. 773-775
Author(s):  
Claire I. Daïen ◽  
Jérémie Sellam ◽  
Nathalie Rincheval ◽  
Bruno Fautrel ◽  
Alain Saraux ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Independent Predictor ◽  
Early Arthritis ◽  
Rheumatoid Arthritis Diagnosis

Serum miR-210 and miR-155 expression levels as novel biomarkers for rheumatoid arthritis diagnosis

2017 ◽  
Vol 74 (4) ◽  
pp. 209-213 ◽  
Author(s):  
RS Abdul-Maksoud ◽  
AM Sediq ◽  
AAA Kattaia ◽  
WSH Elsayed ◽  
N Ezzeldin ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Diagnosis ◽  
Expression Levels ◽  
Novel Biomarkers

scholarly journals Reduced Anti-Histone Antibodies and Increased Risk of Rheumatoid Arthritis Associated with a Single Nucleotide Polymorphism in PADI4 in North Americans

2019 ◽  
Vol 20 (12) ◽  
pp. 3093 ◽  
Author(s):  
Aisha M. Mergaert ◽  
Mandar Bawadekar ◽  
Thai Q. Nguyen ◽  
Laura Massarenti ◽  
Caitlyn L. Holmes ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Single Nucleotide Polymorphism ◽  
Enzyme Linked Immunosorbent Assay ◽  
Human Rheumatoid Arthritis ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Rheumatoid Arthritis Diagnosis ◽  
North Americans ◽  
Increased Risk ◽  
Citrullinated Proteins

Autoantibodies against citrullinated proteins are a hallmark of rheumatoid arthritis, a destructive inflammatory arthritis. Peptidylarginine deiminase 4 (PAD4) has been hypothesized to contribute to rheumatoid arthritis by citrullinating histones to induce neutrophil extracellular traps (NETs), which display citrullinated proteins that are targeted by autoantibodies to drive inflammation and arthritis. Consistent with this theory, PAD4-deficient mice have reduced NETs, autoantibodies, and arthritis. However, PAD4′s role in human rheumatoid arthritis is less clear. Here, we determine if single nucleotide polymorphism rs2240335 in PADI4, whose G allele is associated with reduced PAD4 in neutrophils, correlates with NETs, anti-histone antibodies, and rheumatoid arthritis susceptibility in North Americans. Control and rheumatoid arthritis subjects, divided into anti-cyclic citrullinated peptide (CCP) antibody positive and negative groups, were genotyped at rs2240335. In homozygotes, in vitro NETosis was quantified in immunofluorescent images and circulating NET and anti-histone antibody levels by enzyme linked immunosorbent assay (ELISA). Results were compared by t-test and correlation of rheumatoid arthritis diagnosis with rs2240335 by Armitage trend test. NET levels did not significantly correlate with genotype. G allele homozygotes in the CCP− rheumatoid arthritis group had reduced anti-native and anti-citrullinated histone antibodies. However, the G allele conferred increased risk for rheumatoid arthritis diagnosis, suggesting a complex role for PAD4 in human rheumatoid arthritis.

scholarly journals Relationships Between Driving Distance, Rheumatoid Arthritis Diagnosis, and Disease-Modifying Antirheumatic Drug Receipt

2014 ◽  
Vol 66 (11) ◽  
pp. 1634-1643 ◽  
Author(s):  
Jennifer M. Polinski ◽  
M. Alan Brookhart ◽  
John Z. Ayanian ◽  
Jeffrey N. Katz ◽  
Seoyoung C. Kim ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Antirheumatic Drug ◽  
Rheumatoid Arthritis Diagnosis ◽  
Disease Modifying ◽  
Disease Modifying Antirheumatic Drug

scholarly journals FRI0095 Pilot study of the early rheumatoid arthritis diagnosis program with a structured referral format

2017 ◽  
Author(s):  
J Jaimes-Hernandez ◽  
P Aranda-Pereira ◽  
CI Melendez-Mercado ◽  
A Mendoza-Fuentes ◽  
I Guzman-Sanchez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Pilot Study ◽  
Early Rheumatoid Arthritis ◽  
Rheumatoid Arthritis Diagnosis
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