scholarly journals Mediating Role of Bone Marrow Lesions, Synovitis, Pain Sensitization, and Depressive Symptoms on Knee Pain Improvement Following Substantial Weight Loss

2020 ◽  
Vol 72 (3) ◽  
pp. 420-427
Author(s):  
S. Reza Jafarzadeh ◽  
Tuhina Neogi ◽  
Joshua J. Stefanik ◽  
Jing‐Sheng Li ◽  
Ali Guermazi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Weight Loss ◽  
Depressive Symptoms ◽  
Knee Pain ◽  
Bone Marrow Lesions ◽  
Mediating Role ◽  
Pain Sensitization ◽  
Pain Improvement

scholarly journals Assessing Mediating Effect of Bone Marrow Lesions and Synovitis Following Extreme Weight Loss on Knee Pain Reduction

2017 ◽  
Vol 25 ◽  
pp. S333
Author(s):  
S.-R. Jafarzadeh ◽  
A. Guermazi ◽  
J.-S. Li ◽  
M. Clancy ◽  
C.A. Brown ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Weight Loss ◽  
Knee Pain ◽  
Pain Reduction ◽  
Mediating Effect ◽  
Bone Marrow Lesions

Co-Rumination and Depressive Symptoms in Adolescence: Prospective Associations and the Mediating Role of Brooding Rumination

2021 ◽  
Vol 50 (5) ◽  
pp. 1003-1016
Author(s):  
Margot Bastin ◽  
Koen Luyckx ◽  
Filip Raes ◽  
Patricia Bijttebier
Keyword(s):  
Depressive Symptoms ◽  
Mediating Role

scholarly journals Maternal depressive symptoms and children's academic performance: sex differences in the mediating role of school experiences

2020 ◽  
pp. 1-10
Author(s):  
Marilyn N. Ahun ◽  
Lamprini Psychogiou ◽  
Frédéric Guay ◽  
Michel Boivin ◽  
Richard E. Tremblay ◽  
...  
Keyword(s):  
Sex Differences ◽  
Depressive Symptoms ◽  
Peer Victimization ◽  
School Engagement ◽  
School Experiences ◽  
Maternal Depressive Symptoms ◽  
Reading And Writing ◽  
Mediating Role ◽  
Writing Scores

Abstract Background Maternal depressive symptoms (MDSs) are negatively associated with children's academic performance, with stronger effects sometimes reported in boys. However, few studies have tested the mechanisms of this association. We examined the mediating role of school engagement and peer victimization in this association and tested for sex differences. Methods Participants were 1173 families from a population-based longitudinal Canadian study. MDSs were self-reported annually using the Centre for Epidemiologic Studies Depression Scale (child's age: 5 months to 5 years). Data on mediators (peer victimization, cognitive, behavioral, and emotional school engagement) were reported annually from ages 6–10 by multiple informants including children, parents, and teachers using items from validated scales. Mathematics, reading, and writing exam scores at age 12 were obtained from standardized exams administered by Québec's Ministry of Education and Teaching. Structural equation modeling was used to test mediation by school experiences in boys and girls. Results Exposure to MDSs was negatively associated with mathematics, reading, and writing scores in girls and with mathematics only in boys. Cognitive and behavioral engagement significantly mediated the association between MDSs and mathematics, reading, and writing scores in girls. There were no significant mediators for boys. Conclusions Prevention and intervention strategies aiming to improve school engagement might be beneficial for daughters of mothers experiencing depressive symptoms. Further research is needed to replicate these findings and to identify the mechanisms explaining this association in boys.

scholarly journals Inhibitory control mediates the interaction between serotonin transporter gene (5-HTTLPR) and peer victimization on adolescent depressive symptoms

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Xiaonan Lin ◽  
Yanmiao Cao ◽  
Linqin Ji ◽  
Wenxin Zhang
Keyword(s):  
Depressive Symptoms ◽  
Peer Victimization ◽  
Inhibitory Control ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Chinese Han ◽  
Mediating Role ◽  
Adolescent Depressive Symptoms

AbstractMany efforts have been devoted to investigating the effect of the interaction between the serotonin transporter gene (5-HTTLPR) and environment (G × E) on depression, but they yield mixed results. The inconsistency has suggested that G × E effects may be more complex than originally conceptualized, and further study is warranted. This study explored the association among 5-HTTLPR, peer victimization and depressive symptoms and the underlying mediating role of inhibitory control in this association. A total of 871 Chinese Han adolescents (Mage = 15.32 years, 50.3% girls) participated and provided saliva samples from which the 5-HTTLPR was genotyped. This study found that 5-HTTLPR interacted with peer victimization in predicting depressive symptoms. Adolescents carrying L allele reported more depressive symptoms than SS carriers when exposed to higher level of peer victimization. Furthermore, adolescents’ inhibitory control deficits mediated the association between 5-HTTLPR × peer victimization and depressive symptoms. These findings suggested that one pathway in which G × E may confer vulnerability to depressive symptoms is through disruptions to adolescents’ inhibitory control system.

Pain intensity and physical performance among individuals with fibromyalgia in mid-to-late life: The influence of depressive symptoms

2021 ◽  
pp. 135910532110092
Author(s):  
Dylan G Serpas ◽  
Laura Zettel-Watson ◽  
Barbara J Cherry
Keyword(s):  
Depressive Symptoms ◽  
Pain Intensity ◽  
Physical Performance ◽  
Walk Test ◽  
Mediation Analyses ◽  
Mediating Role ◽  
6 Minute Walk Test ◽  
The Relationship ◽  
Minute Walk

This study investigated the mediating role of depressive symptoms among 147 middle-aged and older adults with FM in the relationship between pain intensity and 4 objective measures of physical performance: Fullerton Advanced Balance scale (FAB), 6-Minute Walk Test (6MWT), 30-Second Chair Stand (30SCS), and 8-Foot Up and Go Test (8FUPGT). Asymptotic mediation analyses revealed that depressive symptoms fully mediated the relationship between pain intensity and FAB (95% CI [−0.40, −0.10]) and 8FUPGT (CI [0.02, 0.11]) and partially mediated the relationship to 6MWT (CI [−9.15, −2.20]) and 30SCS (CI [−0.29, −0.06]). Findings support the evaluation of co-morbid depression in FM.

A population-based study of the association between hip bone marrow lesions, high cartilage signal, and hip and knee pain

2013 ◽  
Vol 33 (3) ◽  
pp. 369-376 ◽  
Author(s):  
Harbeer Ahedi ◽  
Dawn Aitken ◽  
Leigh Blizzard ◽  
Flavia Cicuttini ◽  
Graeme Jones
Keyword(s):  
Bone Marrow ◽  
Knee Pain ◽  
Population Based ◽  
Population Based Study ◽  
Bone Marrow Lesions

The mediating role of disability and social support in the association between low vision and depressive symptoms in older adults

2013 ◽  
Vol 23 (3) ◽  
pp. 1039-1043 ◽  
Author(s):  
Gertrudis I. J. M. Kempen ◽  
Adelita V. Ranchor ◽  
Ton Ambergen ◽  
G. A. Rixt Zijlstra
Keyword(s):  
Social Support ◽  
Older Adults ◽  
Depressive Symptoms ◽  
Low Vision ◽  
Mediating Role

scholarly journals Satisfaction with Life: Mediating Role in the Relationship between Depressive Symptoms and Coping Mechanisms

Healthcare ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 787
Author(s):  
Daniela Almeida ◽  
Diogo Monteiro ◽  
Filipe Rodrigues
Keyword(s):  
Life Satisfaction ◽  
Depressive Symptoms ◽  
Coping Strategies ◽  
Satisfaction With Life ◽  
Well Being ◽  
Coping Mechanisms ◽  
Significant Positive Association ◽  
Mediating Role ◽  
The Relationship

The purpose of this study was to analyze the mediating role of life satisfaction in the relationship between fourteen coping strategies and depressive symptoms in the Portuguese population. To undertake this work, 313 Portuguese adults aged 18 to 70 years (M = 30.73; SD = 10.79) were invited to participate in this study. Their participation was completely voluntary, and participants granted and signed informed consent previously to the filling of the validated Portuguese questionnaires. These questionnaires measured depressive symptoms, coping, and life satisfaction. The results revealed that life satisfaction displayed a mediating role in the relationship between adaptive coping mechanisms, specifically between active coping, planning, reinterpretation, and acceptance and depressive symptoms, showing a negative and significant indirect effect. Maladaptive coping mechanisms of self-blame, denial, self-distraction, disengagement, and substance use had a significant positive association with depressive symptoms, considering the mediating role of satisfaction with life. Current investigation provides initial evidence of how each coping mechanism is associated with satisfaction with life and depressive symptoms. This study clearly demonstrates that not all coping strategies are capable of influencing well-being indicators and that health professionals should focus on endorsing those that are significantly associated with lowering depressive symptoms and increasing overall satisfaction with life.

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