Development of Joint Erosions in the Preclinical Phase of Rheumatoid Arthritis Depicted by Cinematic Rendering

2019 ◽  
Vol 71 (9) ◽  
pp. 1592-1592 ◽  
Author(s):  
David Simon ◽  
Georg Schett ◽  
Arnd Kleyer
Keyword(s):  
Rheumatoid Arthritis ◽  
Cinematic Rendering ◽  
Preclinical Phase ◽  
Joint Erosions

scholarly journals Effects of Antitumor Necrosis Factor Therapy on Osteoprotegerin, Neopterin, and sRANKL Concentrations in Patients with Rheumatoid Arthritis

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Katharina Kurz ◽  
Manfred Herold ◽  
Elisabeth Russe ◽  
Werner Klotz ◽  
Guenter Weiss ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Systemic Autoimmune Disease ◽  
Das28 Score ◽  
Reactive Protein ◽  
Adalimumab Therapy ◽  
Receptor Activator ◽  
Joint Erosions ◽  
Factor Therapy ◽  
Necrosis Factor

Background. Rheumatoid arthritis is a systemic autoimmune disease characterized by joint erosions, progressive focal bone loss, and chronic inflammation.Methods. 20 female patients with moderate-to-severe rheumatoid arthritis were treated with anti-TNF-antibody adalimumab in addition to concomitant antirheumatic therapies. Patients were assessed for overall disease activity using the DAS28 score, and neopterin, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) concentrations as well as osteoprotegerin (OPG) and soluble receptor activator of NF-κB ligand (sRANKL) concentrations were determined before therapy and at week 12. Neopterin as well as OPG and sRANKL were determined by commercial ELISAs.Results. Before anti-TNF therapy patients presented with high disease activity and elevated concentrations of circulating inflammatory markers. OPG concentrations correlated with neopterin (rs=0.494,p=0.027), but not with DAS28. OPG concentrations and disease activity scores declined during anti-TNF-treatment (bothp<0.02). Patients who achieved remission (n=7) or showed a good response according to EULAR criteria (n=13) presented with initially higher baseline OPG levels, which subsequently decreased significantly during treatment (p=0.018for remission,p=0.011for good response).Conclusions. Adalimumab therapy was effective in modifying disease activity and reducing proinflammatory and bone remodelling cascades.

A7.8 Autonomic dysfunction in the preclinical phase of rheumatoid arthritis

2015 ◽  
Vol 74 (Suppl 1) ◽  
pp. A77.2-A78
Author(s):  
FA Koopman ◽  
MW Tang ◽  
J Vermeij ◽  
MJ de Hair ◽  
IY Choi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Autonomic Dysfunction ◽  
Preclinical Phase

scholarly journals Osteopontin, Osteoprotegerin and Musculoskeletal Ultrasound findings in First-Degree Relatives of Rheumatoid Arthritis: Potential Markers of Preclinical Disease

2020 ◽  
Author(s):  
Eiman Soliman ◽  
Sarah Ohrndorf ◽  
Magdy Zehairy ◽  
Khaled Matrawy ◽  
Abeer Alhadidy ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Metabolism ◽  
Clinical Laboratory ◽  
Joint Inflammation ◽  
Musculoskeletal Ultrasound ◽  
First Degree Relatives ◽  
Preclinical Phase ◽  
Increased Risk ◽  
Significant Difference ◽  
Clinical Arthritis

Abstract Background: First-degree relatives (FDRs) of rheumatoid arthritis (RA) patients are known to have increased risk of developing the disease. The detection of altered bone metabolism in FDRs could be a predictor of the disease. Preclinical phase of RA is characterized by a state of autoimmunity and inflammation. Musculoskeletal ultrasound (MSUS) is known for its ability to detect subclinical joint inflammation in RA, but changes in FDRs are not yet described.Objectives: To study serum osteopontin (OPN) and osteoprotegerin (OPG) levels in first degree relatives (FDRs) of rheumatoid arthritis (RA) as markers of altered bone metabolism in relation to clinical, laboratory and musculoskeletal ultrasound (MSUS) findings. Methods: Fifty-five individuals were included, 20 had definite RA, 25 were FDRs of RA patients, and 10 healthy controls. Clinical evaluation for joint swelling/tenderness was performed for all. ESR, CRP, rheumatoid factor (RF), anti-citrullinated antibodies (ACPA), OPN, OPG, and MSUS by the US7 score were evaluated.Results: OPG was significantly higher in RA (143.89 pg/ml±365.47) than in FDRs (22.23 pg/ml±65.73; p=0.009) and controls (6.20 pg/ml±12.43; p=0.003). OPN was also higher in RA (3.66 ng/ml±4.20) than in FDRs (1.97 ng/ml±1.04) and controls (2.81 ng/ml±1.31), though not significant (p=0.102). Eight of 25 FDRs (32%) had arthralgia without clinical arthritis and 17/25 (68%) were asymptomatic. FDRs with arthralgia had significantly higher ESR and CRP levels than asymptomatic FDRs (9.82 mm/h±4.13; p=0.003, and 3.93 mg/l±3.58; p=0.003). OPG was higher in FDRs than in controls, and also in those with arthralgia (51.55 pg/ml±114.68) than in those without (8.44 pg/ml±9.67), though without significant difference. OPN was higher in FDRs with arthralgia (2.09 ng/ml±1.19) than in asymptomatics (1.70 ng/ml±0.55), also without significant difference. Pathologic findings by US7 were detected in 10/25 (40%) FDRs, of which three (12%) had arthralgia and seven (28%) were asymptomatic. Conclusions: The raised OPG and lower OPN in FDRs than in controls reflect an altered bone metabolism which could precede clinical disease phase. OPN and OPG could serve as markers of altered preclinical bone metabolism in FDRs of RA. US7 score might be a useful screening tool to identify ‘at-risk’ individuals.

scholarly journals Serum Dickkopf-1 as a potential prognostic marker in patients with rheumatoid arthritis

2021 ◽  
Vol 48 (1) ◽  
Author(s):  
Dina A. Ali ◽  
Doaa Mohamed Esmail ◽  
Haidy Ali Mohammed ◽  
Reham Lotfy Yonis ◽  
Radwa Mahmoud El-Sharaby
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity Score ◽  
Joint Destruction ◽  
Control Group ◽  
Joint Erosions ◽  
Low Levels ◽  
Future Therapy ◽  
Dickkopf 1 ◽  
Inhibitory Regulation

Abstract Background Rheumatoid arthritis (RA) is a disease of an autoimmune nature that involves all types of joints structures and manifested by chronic joints inflammations and thus their erosions and damage. Dickkopf-1 (DKK-1) is a molecule that has an inhibitory regulation of wingless/integrated genes (Wnt) pathway and has a major role in models of animals with arthritis or joint destruction. Increased DKK-1 levels are implicated in higher resorption of the bone in cases of rheumatoid arthritis and thus with higher probability for joint deformities, while low levels associated with formation of new bone by osteoblasts, we aimed to study the prognostic role of circulating Dickkopf-1 in rheumatoid arthritis. Results The present study revealed that the DKK-1 levels were significantly increased in RA patients in relation to the control group (P=0.001). We found a significant positive correlation between DKK-1 level and ESR (P=0.001), Disease Activity Score (DAS 28) (P=0.001), the disease duration (P=0.001), and the presence of bone erosions in plain X-ray of hands (P =0.001). Moreover, we revealed that, at cutoff value 2150, the DKK-1 in RA has 90% sensitivity and 85% specificity. Conclusions DKK-l serum level can be used as a potential prognostic biomarker for monitoring of joint erosions and destruction in RA patients. Furthermore, it could be a possible target molecule in the future therapy to control the process of joint destruction.

Subclinical inflammation in the preclinical phase of rheumatoid arthritis might contribute to articular joint damage

2020 ◽  
Vol 81 (12) ◽  
pp. 726-731
Author(s):  
Mariela Gomez-Moreno ◽  
Elsy Janet Ramos-González ◽  
Julio Enrique Castañeda-Delgado ◽  
José Dionicio Castillo-Ortiz ◽  
Cesar Ramos-Remus ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Joint Damage ◽  
Subclinical Inflammation ◽  
Preclinical Phase ◽  
Articular Joint
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