scholarly journals A Fifty‐Two–Week, Randomized, Placebo‐Controlled Trial of Certolizumab Pegol in Nonradiographic Axial Spondyloarthritis

2019 ◽  
Vol 71 (7) ◽  
pp. 1101-1111 ◽  
Author(s):  
Atul Deodhar ◽  
Lianne S. Gensler ◽  
Jonathan Kay ◽  
Walter P. Maksymowych ◽  
Nigil Haroon ◽  
...  
Keyword(s):  
Axial Spondyloarthritis ◽  
Controlled Trial ◽  
Certolizumab Pegol ◽  
Nonradiographic Axial Spondyloarthritis

scholarly journals Tumor necrosis factor-α (TNFα) inhibitors in the treatment of nonradiographic axial spondyloarthritis: current evidence and place in therapy

2017 ◽  
Vol 9 (8) ◽  
pp. 197-210 ◽  
Author(s):  
Valeria Rios Rodriguez ◽  
Denis Poddubnyy
Keyword(s):  
Ankylosing Spondylitis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Axial Spondyloarthritis ◽  
Efficacy And Safety ◽  
Tnfα Inhibitors ◽  
Factor Α ◽  
Nonradiographic Axial Spondyloarthritis ◽  
Necrosis Factor

Nonradiographic axial spondyloarthritis (SpA) and radiographic SpA (also known as ankylosing spondylitis) are currently considered as two stages or forms of one disease (axial SpA). The treatment with tumor necrosis factor-α (TNFα) inhibitors has been authorized for years for ankylosing spondylitis. In recent years, most of the anti-TNFα agents have also been approved for the treatment of nonradiographic axial SpA by the European Medicines Agency (EMA) and similar authorities in many countries around the world (but not in the US), increasing the number of possible therapies for this indication. Data from several clinical trials have demonstrated the good efficacy and safety profiles from those anti-TNFα agents. Presently, a large number of patients achieve a satisfactory clinical control with the current therapies, however, there remains a percentage refractory to nonsteroidal anti-inflammatory drugs (NSAIDs) and TNFα inhibitors; therefore, several new drugs are currently under investigation. In 2015, the first representative of a new class of biologics [an interleukin (IL)-17 inhibitor] secukinumab, was approved for the treatment of ankylosing spondylitis; a clinical trial in nonradiographic axial SpA is currently underway. In this review, we discuss the recent data on efficacy and safety of TNFα-inhibitors focusing on the treatment of nonradiographic axial SpA.

Sensitivity and Specificity of Autoantibodies Against CD 74 in Nonradiographic Axial Spondyloarthritis

2019 ◽  
Vol 71 (5) ◽  
pp. 729-735 ◽  
Author(s):  
Elke Riechers ◽  
Niklas Baerlecken ◽  
Xenofon Baraliakos ◽  
Katrin Achilles‐Mehr Bakhsh ◽  
Peer Aries ◽  
...  
Keyword(s):  
Sensitivity And Specificity ◽  
Axial Spondyloarthritis ◽  
Nonradiographic Axial Spondyloarthritis

A Randomized, Placebo-Controlled Trial of Certolizumab Pegol (CDP870) for Treatment of Crohn’s Disease

2005 ◽  
Vol 129 (3) ◽  
pp. 807-818 ◽  
Author(s):  
Stefan Schreiber ◽  
Paul Rutgeerts ◽  
Richard N. Fedorak ◽  
Munaa Khaliq–Kareemi ◽  
Michael A. Kamm ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Controlled Trial ◽  
Certolizumab Pegol
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