Is the T Follicular Regulatory:Follicular Helper T Cell Ratio in Blood a Biomarker for Ectopic Lymphoid Structure Formation in Sjögren's Syndrome? Comment on the Article by Fonseca et al

2018 ◽  
Vol 70 (8) ◽  
pp. 1354-1355 ◽  
Author(s):  
Gwenny M. Verstappen ◽  
Uzma Nakshbandi ◽  
Esther Mossel ◽  
Erlin A. Haacke ◽  
Bert van der Vegt ◽  
...  
Keyword(s):  
T Cell ◽  
Structure Formation ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Helper T Cell ◽  
Cell Ratio ◽  
Sjögren‘S Syndrome

scholarly journals Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma

2020 ◽  
Vol 79 (12) ◽  
pp. 1588-1599 ◽  
Author(s):  
Elena Pontarini ◽  
William James Murray-Brown ◽  
Cristina Croia ◽  
Davide Lucchesi ◽  
James Conway ◽  
...  
Keyword(s):  
T Cell ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Pcr Analysis ◽  
Organ Cultures ◽  
Cytokine Detection ◽  
Costimulatory Pathway ◽  
Sjögren‘S Syndrome

ObjectivesTo explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa-associated lymphoid tissue (MALT) lymphomas (MALT-L) in Sjögren’s syndrome (SS) patients.MethodsSalivary gland (SG) biopsies with matched peripheral blood were collected from four centres across the European Union. Transcriptomic (microarray and quantitative PCR) analysis, FACS T-cell immunophenotyping with intracellular cytokine detection, multicolor immune-fluorescence microscopy and in situ hybridisation were performed to characterise lesional and circulating Tfh and Tph-cells. SG-organ cultures were used to investigate functionally the blockade of T-cell costimulatory pathways on key proinflammatory cytokine production.ResultsTranscriptomic analysis in SG identified Tfh-signature, interleukin-21 (IL-21) and the inducible T-cell co-stimulator (ICOS) costimulatory pathway as the most upregulated genes in ELS+SS patients, with parotid MALT-L displaying a 400-folds increase in IL-21 mRNA. Peripheral CD4+CXC-motif chemokine receptor 5 (CXCR5)+programmed cell death protein 1 (PD1)+ICOS+ Tfh-like cells were significantly expanded in ELS+SS patients, were the main producers of IL-21, and closely correlated with circulating IgG and reduced complement C4. In the SG, lesional CD4+CD45RO+ICOS+PD1+ cells selectively infiltrated ELS+ tissues and were aberrantly expanded in parotid MALT-L. In ELS+SG and MALT-L parotids, conventional CXCR5+CD4+PD1+ICOS+Foxp3- Tfh-cells and a uniquely expanded population of CXCR5-CD4+PD1hiICOS+Foxp3- Tph-cells displayed frequent IL-21/interferon-γ double-production but poor IL-17 expression. Finally, ICOS blockade in ex vivo SG-organ cultures significantly reduced the production of IL-21 and inflammatory cytokines IL-6, IL-8 and tumour necrosis factor-α (TNF-α).ConclusionsOverall, these findings highlight Tfh and Tph-cells, IL-21 and the ICOS costimulatory pathway as key pathogenic players in SS immunopathology and exploitable therapeutic targets in SS.

Prevalence of Sjögren's syndrome in Brazilian patients infected with human T-cell lymphotropic virus

2016 ◽  
Vol 46 (7) ◽  
pp. 543-548 ◽  
Author(s):  
Daniela Assis do Vale ◽  
Jorge Casseb ◽  
Augusto César Penalva de Oliveira ◽  
Ivo Bussoloti Filho ◽  
Suzana Cantanhede Orsini Machado de Sousa ◽  
...  
Keyword(s):  
T Cell ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Human T Cell ◽  
Sjögren‘S Syndrome

T cell lymphoma in a patient with longstanding rheumatoid arthritis and Sjögren's syndrome

1987 ◽  
Vol 30 (1) ◽  
pp. 115-117 ◽  
Author(s):  
D. A. Isenberg ◽  
M. H. Griffiths ◽  
M. Rustin ◽  
F. W. S. Webb ◽  
R. L. Southami
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cell ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Cell Lymphoma ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
T Cell Lymphoma ◽  
Sjögren‘S Syndrome

scholarly journals T cell receptor expression in Sjogren's syndrome.

1991 ◽  
Vol 50 (10) ◽  
pp. 691-693 ◽  
Author(s):  
A Zumla ◽  
M Mathur ◽  
J Stewart ◽  
L Wilkinson ◽  
D Isenberg
Keyword(s):  
T Cell ◽  
Sjögren’S Syndrome ◽  
T Cell Receptor ◽  
Sjögren's Syndrome ◽  
Cell Receptor ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Receptor Expression ◽  
Sjögren‘S Syndrome
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