scholarly journals EZH2 Modulates the DNA Methylome and Controls T Cell Adhesion Through Junctional Adhesion Molecule A in Lupus Patients

2017 ◽  
Vol 70 (1) ◽  
pp. 98-108 ◽  
Author(s):  
Pei‐Suen Tsou ◽  
Patrick Coit ◽  
Nathan C. Kilian ◽  
Amr H. Sawalha
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Adhesion Molecule ◽  
Dna Methylome ◽  
T Cell Adhesion

scholarly journals Two Distinct Intracytoplasmic Regions of the T-cell Adhesion Molecule CD28 Participate in Phosphatidylinositol 3-Kinase Association

1996 ◽  
Vol 271 (16) ◽  
pp. 9403-9409 ◽  
Author(s):  
Françoise Pagès ◽  
Marguerite Ragueneau ◽  
Sandrine Klasen ◽  
Michela Battifora ◽  
Dominique Couez ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Phosphatidylinositol 3 Kinase ◽  
Phosphatidylinositol 3 ◽  
T Cell Adhesion

scholarly journals Regulatory role of CD43 leukosialin on integrin-mediated T-cell adhesion to endothelial and extracellular matrix ligands and its polar redistribution to a cellular uropod

Blood ◽  
1995 ◽  
Vol 86 (6) ◽  
pp. 2228-2239 ◽  
Author(s):  
P Sanchez-Mateos ◽  
MR Campanero ◽  
MA del Pozo ◽  
F Sanchez-Madrid
Keyword(s):  
T Cells ◽  
Cell Adhesion ◽  
T Cell ◽  
Cell Surface ◽  
Adhesion Molecule ◽  
Negative Regulator ◽  
Regulatory Role ◽  
Beta 2 ◽  
T Lymphoblasts ◽  
T Cell Adhesion

CD43 is a cell surface-associated mucin that is abundantly expressed by most leukocytes, and that appears to function as a negative regulator of cell surface interactions, providing a repulsive barrier around cells. We have analyzed herein the ability of anti-CD43 monoclonal antibody (MoAb) to upregulate both beta 1 and beta 2 integrin-mediated cell adhesion and to promote redistribution of the CD43 molecule into a cellular uropod. Engagement of CD43 with specific antibodies enhanced the cell adhesion to both 80- and 38-kD fibronectin fragments as well as to the endothelial cell ligands vascular cell adhesion molecule-1 and intercellular adhesion molecule-1, an effect that was mediated through the alpha 5 beta 1, alpha 4 beta 1, and alpha L beta 2 integrins, respectively. This effect on cell adhesion was achieved in Jurkat leukemic T cells by anti-CD43 MoAb alone; however, in T lymphoblasts, the activation of cell adhesion required the concomitant ligation of CD3 with suboptimal doses of anti-CD3 MoAb. Immunofluorescence analysis showed that the engagement of CD43 was accompanied by a differential redistribution of CD43 into a well- defined cytoplasmic projection or uropod, whereas the beta 1 or beta 2 integrins remained uniformly located on the contact area with substrata. This change in the localization of CD43 did not require costimulation and was induced directly by engagement of CD43 in T lymphoblasts. Other stimuli of cell adhesion in the form of cross- linked anti-CD3 MoAb or phorbol esters did not induce uropod formation or CD43 redistribution. In addition, we observed that prolonged co- culture of resting peripheral blood T lymphocytes with endothelial cells, in the absence of anti-CD43 MoAb, induced uropod formation and redistribution of CD43 in T cells. Interestingly, the myosin-disrupting drug butanedione monoxime inhibited the redistribution of CD43 induced by the specific MoAb, whereas the stimulation of cell adhesion induced by engagement of CD43 was preserved in the presence of this drug. These observations indicate that the signaling inducing integrin-mediated cell adhesion by CD43 takes place independently from the receptor redistribution. Altogether, these results indicate that CD43 has a regulatory role on both integrin-mediated T-cell adhesion and cellular morphology.

scholarly journals Low Affinity Interaction of Human or Rat T Cell Adhesion Molecule CD2 with Its Ligand Aligns Adhering Membranes to Achieve High Physiological Affinity

1997 ◽  
Vol 272 (49) ◽  
pp. 30889-30898 ◽  
Author(s):  
Michael L. Dustin ◽  
David E. Golan ◽  
De-Min Zhu ◽  
James M. Miller ◽  
Werner Meier ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Affinity Interaction ◽  
T Cell Adhesion

scholarly journals T cell adhesion and cytolysis of pancreatic cancer cells: a role for E-cadherin in immunotherapy?

2002 ◽  
Vol 87 (9) ◽  
pp. 1034-1041 ◽  
Author(s):  
J J French ◽  
J Cresswell ◽  
W K Wong ◽  
K Seymour ◽  
R M Charnley ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Adhesion ◽  
T Cell ◽  
Cancer Cells ◽  
Pancreatic Cancer Cells ◽  
E Cadherin ◽  
T Cell Adhesion

Structural and ICAM-1-Docking Properties of a Cyclic Peptide from the I-domain of LFA-1: An inhibitor of ICAM-1/LFA-1-mediated T-cell adhesion

2002 ◽  
Vol 19 (5) ◽  
pp. 789-799 ◽  
Author(s):  
Christine R. Xu ◽  
Helena Yusuf-Makagiansar ◽  
Yongbo Hu ◽  
Seetharama D.S. Jois ◽  
Teruna J. Siahaan
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Cyclic Peptide ◽  
T Cell Adhesion

scholarly journals Augmentation of RANTES-Induced Extracellular Signal-Regulated Kinase Mediated Signaling and T Cell Adhesion by Elastase-Treated Fibronectin

2001 ◽  
Vol 166 (12) ◽  
pp. 7121-7127 ◽  
Author(s):  
Alexander Brill ◽  
Rami Hershkoviz ◽  
Gayle G. Vaday ◽  
Yehuda Chowers ◽  
Ofer Lider
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
T Cell Adhesion

scholarly journals Regulation of LFA-1-mediated T cell adhesion by CD4

1991 ◽  
Vol 21 (4) ◽  
pp. 887-894 ◽  
Author(s):  
Fabienne Mazerolles ◽  
Pascale Hauss ◽  
Christiane Barbat ◽  
Carl. G. Figdor ◽  
Alain Fischer
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
T Cell Adhesion

scholarly journals The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

2017 ◽  
Vol 10 (491) ◽  
pp. eaal2880 ◽  
Author(s):  
Inbar Azoulay-Alfaguter ◽  
Marianne Strazza ◽  
Michael Peled ◽  
Hila K. Novak ◽  
James Muller ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
T Cell ◽  
Immunological Synapse ◽  
Tyrosine Phosphatase ◽  
Adaptor Protein ◽  
T Cell Adhesion
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