scholarly journals Brief Report: The Role of Rare Protein‐Coding Variants in Anti–Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis

2017 ◽  
Vol 69 (4) ◽  
pp. 735-741 ◽  
Author(s):  
Jing Cui ◽  
Dorothee Diogo ◽  
Eli A. Stahl ◽  
Helena Canhao ◽  
Xavier Mariette ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Treatment Response ◽  
Tumor Necrosis ◽  
Protein Coding ◽  
Coding Variants ◽  
Necrosis Factor ◽  
Tumor Necrosis Factor Treatment

Persistent Periodontal Disease Hampers Anti–Tumor Necrosis Factor Treatment Response in Rheumatoid Arthritis

2012 ◽  
pp. 1 ◽  
Author(s):  
Cynthia Savioli ◽  
Ana Cristina M. Ribeiro ◽  
Gisele Maria Campos Fabri ◽  
Ana Luisa Calich ◽  
Jozélio Carvalho ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Periodontal Disease ◽  
Treatment Response ◽  
Tumor Necrosis ◽  
Necrosis Factor ◽  
Tumor Necrosis Factor Treatment

CXCL10 and TRAIL Are Upregulated by TXNDC5 in Rheumatoid Arthritis Fibroblast-like Synoviocytes

2017 ◽  
Vol 45 (3) ◽  
pp. 335-340 ◽  
Author(s):  
Bing Xu ◽  
Jian Li ◽  
Changsun Wu ◽  
Chunyan Liu ◽  
Xinfeng Yan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Synovial Fibroblasts ◽  
And Migration ◽  
Interfering Rna ◽  
Synovial Membranes ◽  
Necrosis Factor ◽  
Fibroblast Like Synoviocytes

Objective.Thioredoxin domain containing 5 (TXNDC5) is highly expressed in synovial membranes of rheumatoid arthritis (RA). Our study aimed to investigate the pathogenic role of TXNDC5 in RA.Methods.PCR arrays, CCK-8 assays, flow cytometry, and transwell migration assays were used to analyze cultured rheumatoid arthritis synovial fibroblasts (RASF).Results.Increased CXCL10 and tumor necrosis factor-related apoptosis-inducing ligand levels were detected in RASF transfected with anti-TXNDC5 small interfering RNA (siRNA), and decreased expression was detected in RASF transfected with TXNDC5-expressing plasmids. Significantly attenuated RASF proliferation and migration, and increased RASF apoptosis, were observed in the siRNA-transfected RASF.Conclusion.Downregulation of TXNDC5 could contribute to RASF antiangiogenic and proapoptotic features through the suppression of CXCL10 and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand).

scholarly journals Role of Tumor Necrosis Factor‐Alpha in Rheumatoid Arthritis

2018 ◽  
Vol 32 (S1) ◽  
Author(s):  
Tina Link ◽  
Alisa Kepner ◽  
Olivia Coruso ◽  
Megha Dilip ◽  
Reagan Jacobson ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document