scholarly journals Association of Serum Calprotectin (S100A8/A9) Level With Disease Relapse in Proteinase 3–Antineutrophil Cytoplasmic Antibody–Associated Vasculitis

2016 ◽  
Vol 69 (1) ◽  
pp. 185-193 ◽  
Author(s):  
Ruth J. Pepper ◽  
Juliana B. Draibe ◽  
Ben Caplin ◽  
Fernando C. Fervenza ◽  
Gary S. Hoffman ◽  
...  
Keyword(s):  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Disease Relapse

scholarly journals Biomarkers Predict Relapse in Granulomatosis with Polyangiitis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Patrick C. P. Hogan ◽  
Robert M. O’Connell ◽  
Simone Scollard ◽  
Emmett Browne ◽  
Emer E. Hackett ◽  
...  
Keyword(s):  
Neutrophil Count ◽  
Granulomatosis With Polyangiitis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Organ Damage ◽  
Proteinase 3 ◽  
Disease Relapse ◽  
C Reactive Protein ◽  
Small Blood Vessel ◽  
Reactive Protein ◽  
Specific Reactivity

Granulomatosis with polyangiitis (GPA) is a small blood vessel vasculitic disorder with a high mortality rate if undiagnosed or treated inadequately. Disease relapse is a key feature of this disease and early identification of relapse episodes is very important in limiting end-organ damage. The advent of indirect immunofluorescence to detect antineutrophil cytoplasmic antibody (ANCA) with specific reactivity against the enzyme proteinase-3 (PR3) has been very useful in the diagnosis of GPA but is less helpful in predicting relapse. Indeed, up to date no satisfactory biomarker has been identified that can reliably predict relapse. This study assessed the probability of the occurrence of a relapse when a change was noted in a range of commonly used laboratory tests. These tests included levels of C-reactive protein (CRP), anti-PR3 antibodies, ANCA titre, and the neutrophil count. A group of 30 GPA patients with a total of 66 relapse episodes was investigated and a novel clinical yield score was devised. When a combined rise in CRP, anti-PR3 antibodies, and neutrophil count was observed in the 6-month period before a relapse event, 59% of patient relapses could be predicted. Monitoring changes in this set of parameters helps identify disease relapse.

Azathioprine hypersensitivity syndrome: report of two cases

2021 ◽  
Vol 14 (5) ◽  
pp. e239099
Author(s):  
Tahlia McKenzie ◽  
Shyam Dheda ◽  
Murty Mantha ◽  
Catherine Larsen
Keyword(s):  
Antineutrophil Cytoplasmic Antibody ◽  
Hypersensitivity Syndrome ◽  
Severe Side Effect ◽  
Dramatic Improvement ◽  
Disease Relapse ◽  
Serological Evidence ◽  
Diagnostic Challenge ◽  
Sweet Syndrome ◽  
High Clinical Suspicion ◽  
Syndrome Report

Azathioprine hypersensitivity syndrome is a rare but potentially severe side effect of azathioprine use. It has a variable and non-specific presentation making it difficult to distinguish from sepsis or disease relapse. High clinical suspicion is therefore required for recognition and prompt cessation of azathioprine for symptom resolution. Herewith two cases of severe azathioprine hypersensitivity syndrome are described, one in association with Sweet syndrome. Both presented with vague symptoms 2 weeks after commencing azathioprine for antineutrophil cytoplasmic antibody vasculitis. The differentials of sepsis and disease relapse were considered prior to cessation of azathioprine which resulted in a dramatic improvement in both cases. These cases highlight the diagnostic challenge azathioprine hypersensitivity syndrome presents. It should be suspected when there is a temporal relationship to drug initiation, with absence of infection or serological evidence of disease relapse.

scholarly journals A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

2015 ◽  
Vol 2015 ◽  
pp. 1-5
Author(s):  
Yasuyuki Nakada ◽  
Nobuo Tsuboi ◽  
Yasuto Takahashi ◽  
Hiraku Yoshida ◽  
Yoriko Hara ◽  
...  
Keyword(s):  
Renal Biopsy ◽  
Indirect Immunofluorescence ◽  
Crescentic Glomerulonephritis ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Basement Membranes ◽  
Proteinase 3 ◽  
Renal Deterioration ◽  
Membranous Glomerulopathy ◽  
Immunosorbent Assays ◽  
The Relationship

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.

scholarly journals Clinical evaluation of a capture ELISA for detection of proteinase-3 antineutrophil cytoplasmic antibody: Technical Note

1998 ◽  
Vol 53 (5) ◽  
pp. 1230-1236 ◽  
Author(s):  
Kerstin W.A. Westman ◽  
Daina Selga ◽  
Per Bygren ◽  
Mårten Segelmark ◽  
Bo Baslund ◽  
...  
Keyword(s):  
Clinical Evaluation ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Technical Note ◽  
Proteinase 3 ◽  
Capture Elisa

scholarly journals Infected Aortic Aneurysm Mimicking Anti-proteinase 3-Antineutrophil Cytoplasmic Antibody-associated Vasculitis

2016 ◽  
Vol 55 (23) ◽  
pp. 3465-3469
Author(s):  
Kenta Hachiya ◽  
Kazuaki Wakami ◽  
Atsuhiro Yoshida ◽  
Hisao Suda ◽  
Nobuyuki Ohte
Keyword(s):  
Aortic Aneurysm ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Infected Aortic Aneurysm

Clinical Implication of Proteinase-3-antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias

Lung ◽  
2016 ◽  
Vol 194 (2) ◽  
pp. 235-242 ◽  
Author(s):  
Hironao Hozumi ◽  
Noriyuki Enomoto ◽  
Yoshiyuki Oyama ◽  
Masato Kono ◽  
Tomoyuki Fujisawa ◽  
...  
Keyword(s):  
Clinical Implication ◽  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Idiopathic Interstitial Pneumonias

Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment

2009 ◽  
Vol 71 (01) ◽  
pp. 74-79 ◽  
Author(s):  
N. Miura ◽  
R. Aoyama ◽  
W. Kitagawa ◽  
H. Yamada ◽  
K. Nishikawa ◽  
...  
Keyword(s):  
Antineutrophil Cytoplasmic Antibody ◽  
Proteinase 3 ◽  
Necrotizing Glomerulonephritis
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