scholarly journals Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

2016 ◽  
Vol 68 (8) ◽  
pp. 1887-1898 ◽  
Author(s):  
Yao Fu ◽  
Michael Kinter ◽  
Joanna Hudson ◽  
Kenneth M. Humphries ◽  
Rachel S. Lane ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Sirtuin 3 ◽  
Superoxide Dismutase 2

scholarly journals Sirtuin-3 Protects Cochlear Hair Cells Against Noise-Induced Damage via the Superoxide Dismutase 2/Reactive Oxygen Species Signaling Pathway

2021 ◽  
Vol 9 ◽  
Author(s):  
Wenqi Liang ◽  
Chunli Zhao ◽  
Zhongrui Chen ◽  
Zijing Yang ◽  
Ke Liu ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Oxidative Damage ◽  
Hair Cell ◽  
Signaling Pathway ◽  
Hair Cells ◽  
Cell Injury ◽  
Cell Damage ◽  
Sirtuin 3 ◽  
Cochlear Hair Cells ◽  
Superoxide Dismutase 2

Mitochondrial oxidative stress is involved in hair cell damage caused by noise-induced hearing loss (NIHL). Sirtuin-3 (SIRT3) plays an important role in hair cell survival by regulating mitochondrial function; however, the role of SIRT3 in NIHL is unknown. In this study, we used 3-TYP to inhibit SIRT3 and found that this inhibition aggravated oxidative damage in the hair cells of mice with NIHL. Moreover, 3-TYP reduced the enzymatic activity and deacetylation levels of superoxide dismutase 2 (SOD2). Subsequently, we administered adeno-associated virus-SIRT3 to the posterior semicircular canals and found that SIRT3 overexpression significantly attenuated hair cell injury and that this protective effect of SIRT3 could be blocked by 2-methoxyestradiol, a SOD2 inhibitor. These findings suggest that insufficient SIRT3/SOD2 signaling leads to mitochondrial oxidative damage resulting in hair cell injury in NIHL. Thus, ameliorating noise-induced mitochondrial redox imbalance by intervening in the SIRT3/SOD2 signaling pathway may be a new therapeutic target for hair cell injury.

scholarly journals 222 SUPEROXIDE DISMUTASE 2 DOWNREGULATION AND MITOCHONDRIA RESPIRATION IN OSTEOARTHRITIS

2010 ◽  
Vol 18 ◽  
pp. S103-S104
Author(s):  
C. Gabrielides ◽  
J.L. Scott ◽  
R.W. Taylor ◽  
D.A. Young
Keyword(s):  
Superoxide Dismutase ◽  
Superoxide Dismutase 2

Are Superoxide Dismutase 2 and Nitric Oxide Synthase Polymorphisms Associated with Idiopathic Infertility?

2014 ◽  
Vol 21 (4) ◽  
pp. 565-569 ◽  
Author(s):  
Celine Faure ◽  
Pauline Leveille ◽  
Charlotte Dupont ◽  
Chantal Julia ◽  
Pascale Chavatte-Palmer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Superoxide Dismutase ◽  
Nitric Oxide Synthase ◽  
Idiopathic Infertility ◽  
Oxide Synthase ◽  
Superoxide Dismutase 2

Superoxide Dismutase 2 is Necessary for Key Steps in the Transcoelomic Route of Ovarian Cancer Metastasis

2013 ◽  
Vol 65 ◽  
pp. S20
Author(s):  
Madhubhani LP Hemachandra ◽  
Usawadee Dier ◽  
Larissa M Uusitalo ◽  
Donghui Shin ◽  
Sarah a Engelberth ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Superoxide Dismutase ◽  
Cancer Metastasis ◽  
Key Steps ◽  
Superoxide Dismutase 2

scholarly journals MicroRNAs regulating superoxide dismutase 2 are new circulating biomarkers of heart failure

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Emilie Dubois-Deruy ◽  
Marie Cuvelliez ◽  
Jan Fiedler ◽  
Henri Charrier ◽  
Paul Mulder ◽  
...  
Keyword(s):  
Heart Failure ◽  
Superoxide Dismutase ◽  
Circulating Biomarkers ◽  
Superoxide Dismutase 2

Lentivirally-delivered superoxide dismutase 2 gene therapy in free flaps protects against the late adverse effects of radiotherapy

2014 ◽  
Vol 67 (11) ◽  
pp. 1604
Author(s):  
Aadil A. Khan ◽  
Martin McLaughlin ◽  
Joan Kyula ◽  
Michelle Wilkinson ◽  
Paul A. Harris ◽  
...  
Keyword(s):  
Gene Therapy ◽  
Superoxide Dismutase ◽  
Adverse Effects ◽  
Free Flaps ◽  
Late Adverse Effects ◽  
Superoxide Dismutase 2
Sign in / Sign up

Export Citation Format

Share Document