scholarly journals Glucocorticoid-Induced Leucine Zipper Governs the Therapeutic Potential of Mesenchymal Stem Cells by Inducing a Switch From Pathogenic to Regulatory Th17 Cells in a Mouse Model of Collagen-Induced Arthritis

2015 ◽  
Vol 67 (6) ◽  
pp. 1514-1524 ◽  
Author(s):  
P. Luz-Crawford ◽  
G. Tejedor ◽  
A. L. Mausset-Bonnefont ◽  
E. Beaulieu ◽  
E. F. Morand ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Th17 Cells ◽  
Leucine Zipper ◽  
Therapeutic Potential ◽  
Collagen Induced Arthritis

scholarly journals Therapeutic potential of bone marrow-derived mesenchymal stem cells in formed aortic aneurysms of a mouse model

2014 ◽  
Vol 45 (5) ◽  
pp. e156-e165 ◽  
Author(s):  
A. Yamawaki-Ogata ◽  
X. Fu ◽  
R. Hashizume ◽  
K. L. Fujimoto ◽  
Y. Araki ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Therapeutic Potential ◽  
Aortic Aneurysms

scholarly journals Adipose Derived Stem Cells Ameliorate Atopic Dermatitis by Down-regulating IL-17 Secretion of Th17 Cells in an Ovalbumin-induced Mouse Model

2021 ◽  
Author(s):  
Jingyan Guan ◽  
Yibao Li ◽  
Feng Lu ◽  
Jingwei Feng
Keyword(s):  
Stem Cells ◽  
Atopic Dermatitis ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Th17 Cells ◽  
Therapeutic Potential ◽  
In Vitro Assays ◽  
Adipose Derived Stem Cells ◽  
Bioinformatics Analyses ◽  
Underlying Mechanisms

Abstract Background: Mesenchymal stem cells (MSCs) has therapeutic potential for Atopic dermatitis (AD) due to their immunoregulatory effects. However, the underlying mechanisms for therapeutic efficacy of ADSCs on AD is still unclear. Objectives: We sought to investigate the therapeutic effect and mechanisms of adipose-derived stem cells (ADSCs) on AD using an ovalbumin-induced AD mouse model. Methods: AD mice were treated with mice-derived ADSCs, cortisone, or PBS. The therapeutic effect was determined via gross examination and additional in vitro assays using skin samples and blood. To further explore the underlying mechanisms, RNA sequencing analyses and co-culture assays were conducted.Results: ADSCs treatment attenuated the symptoms associated with AD, decreased the serum IgE level and mast cells infiltration. Tissue levels of T-cell relevant pro-inflammatory cytokine production, including IL-4R and IL-17A, were suppressed in both ADSCs and cortisone treatment groups. Genomics and bioinformatics analyses demonstrated a significant enrichment of certain of inflammation related pathway in the down regulated genes after the application of ADSCs and cortisone, specifically the IL-17 signaling pathway. Co-culture experiments revealed that ADSCs significantly suppressed the expression of pro-inflammation cytokines IL-17A and RORγT, as well as the proliferation of Th17 cells. Moreover, the expression of PD-L1, TGF-β, PGE2 was significantly upregulated in the co-cultured ADSCs compare to monocultured ADSCs. Conclusion: Taken together, our data may demonstrate that ADSCs ameliorate OVA- induced AD in mice by down-regulating IL-17 secretion of Th17 cells.

Therapeutic Potential of Mesenchymal Stem Cells for Scleroderma Induced in Mouse Model

2021 ◽  
pp. 101671
Author(s):  
Dina Fathy Elessawi ◽  
Hala Gabr ◽  
Monda Mohamed Maher Badawy ◽  
Tamer A. Gheita
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Therapeutic Potential

scholarly journals Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma

2017 ◽  
Vol 1 (25) ◽  
pp. 2375-2385 ◽  
Author(s):  
Jerome T. Higgs ◽  
Joo Hyoung Lee ◽  
Hong Wang ◽  
Vishnu C. Ramani ◽  
Diptiman Chanda ◽  
...  
Keyword(s):  
Stem Cells ◽  
Multiple Myeloma ◽  
Mesenchymal Stem Cells ◽  
Mouse Model ◽  
Murine Model ◽  
Therapeutic Potential ◽  
Bone Damage ◽  
Key Points

Key Points The study developed a mouse model of bone disseminated myeloma disease as in humans. The study established therapeutic potential of OPG variants to revert myeloma bone damage in vivo.

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