scholarly journals Epigenome-Wide Scan Identifies a Treatment-Responsive Pattern of Altered DNA Methylation Among Cytoskeletal Remodeling Genes in Monocytes and CD4+ T Cells From Patients With Behçet's Disease

2014 ◽  
Vol 66 (6) ◽  
pp. 1648-1658 ◽  
Author(s):  
Travis Hughes ◽  
Filiz Ture-Ozdemir ◽  
Fatma Alibaz-Oner ◽  
Patrick Coit ◽  
Haner Direskeneli ◽  
...  
Keyword(s):  
Dna Methylation ◽  
T Cells ◽  
Behçet’S Disease ◽  
Cd4 T Cells ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Cytoskeletal Remodeling

scholarly journals Decreased expression of Sirt1 contributes to ocular Behcet’s disease progression via Th17 and Th22 response

2020 ◽  
Author(s):  
Manyun Xie ◽  
Yan Yang
Keyword(s):  
T Cells ◽  
Behçet’S Disease ◽  
Cd4 T Cells ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Cell Counting ◽  
Behcet's Disease ◽  
Sirt1 Expression ◽  
Th22 Cells

Background: Previous studies have indicated that Sirtuin 1 (Sirt1) plays an important role in suppressing inflammatory responses in many diseases. However, the Sirt1 levels and role of Sirt1 in ocular Behcet’s disease (OBD) have not been fully elucidated. Objective: To investigate the role of Sirt1 in the pathogenesis of OBD. Methods: Sirt1 and cytokine levels were measured using enzyme-linked immunosorbent assay (ELISA). Cell viability was determined using the Cell Counting Kit-8. The frequencies of Th17 and Th22 cells were detected using flow cytometry. Results: We found decreased expression of Sirt1 in CD4+ T cells obtained from patients with active OBD. SRT1720, an agonist of Sirt1, significantly upregulated Sirt1 expression in CD4+ T cells from patients with active OBD. Sirt1 activation by SRT1720 significantly suppressed the production of interleukin (IL)-17 and IL-22 by CD4+ T cells and inhibited the expansion of Th17 and Th22 cells. Conclusion: Our results suggest that decreased Sirt1 expression might be involved in the pathogenesis of OBD and that activation of Sirt1 might be considered a potential target for OBD.

scholarly journals Excessive CD4+ T cells co-expressing interleukin-17 and interferon-γ in patients with Behçet's disease

2012 ◽  
Vol 168 (1) ◽  
pp. 68-74 ◽  
Author(s):  
J. Shimizu ◽  
K. Takai ◽  
N. Fujiwara ◽  
N. Arimitsu ◽  
Y. Ueda ◽  
...  
Keyword(s):  
T Cells ◽  
Behçet’S Disease ◽  
Cd4 T Cells ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interferon Γ ◽  
Interleukin 17 ◽  
Behcet's Disease

Role of γδ T cells in Behcet's disease

The Lancet ◽  
1996 ◽  
Vol 347 (9015) ◽  
pp. 1631-1632 ◽  
Author(s):  
J.S.H. Gaston ◽  
Adam Hasan ◽  
Farida Fortune ◽  
Amanda Wilson ◽  
Thomas Lehner
Keyword(s):  
T Cells ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Γδ T Cells ◽  
Behcet's Disease

Nanocurcumin supplementation ameliorates Behcet’s disease by modulating regulatory T cells: A randomized, double‐blind, placebo‐controlled trial

2021 ◽  
Vol 101 ◽  
pp. 108237
Author(s):  
Samaneh Abbasian ◽  
Mohammad Sadegh Soltani-Zangbar ◽  
Alireza Khabbazi ◽  
Rojin Farzaneh ◽  
Aida Malek Mahdavi ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Controlled Trial ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Behcet's Disease

scholarly journals Analysis of interleukin-2 activity in patients with Behçet's disease. Ability of T cells to produce and respond to interleukin-2

1986 ◽  
Vol 29 (3) ◽  
pp. 371-378 ◽  
Author(s):  
Tsuyoshi Sakane ◽  
Noboru Suzuki ◽  
Yuji Ueda ◽  
Shinsuke Takada ◽  
Yohko Murakawa ◽  
...  
Keyword(s):  
T Cells ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Interleukin 2 ◽  
Behcet's Disease
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