scholarly journals A Genome-Wide Association Study RevealsARL15, a Novel Non-HLA Susceptibility Gene for Rheumatoid Arthritis in North Indians

2013 ◽  
Vol 65 (12) ◽  
pp. 3026-3035 ◽  
Author(s):  
Sapna Negi ◽  
Garima Juyal ◽  
Sabyasachi Senapati ◽  
Pushplata Prasad ◽  
Aditi Gupta ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Susceptibility Gene ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
North Indians

scholarly journals Genome-wide association study of antipsychotic-induced sinus bradycardia in Chinese schizophrenia patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249997
Author(s):  
Saizheng Weng ◽  
Bo Wang ◽  
Mo Li ◽  
Shan Chao ◽  
Ruiqian Lin ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Sinus Bradycardia ◽  
Susceptibility Gene ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Second-generation antipsychotics (SGAs) play a critical role in current treatment of schizophrenia (SCZ). It has been observed that sinus bradycardia, rare but in certain situations life threatening adverse drug reaction, can be induced by SGAs across different schizophrenia populations. However, the roles of genetic factors in this phenomenon have not been studied yet. In the present study, a genome-wide association study of single nucleotide polymorphisms (SNPs) was performed on Chinese Han SCZ patients to identify susceptibility loci that were associated with sinus bradycardia induced by SGAs. This study applied microarray to obtain genotype profiles of 88 Han Chinese SCZ patients. Our results found that there were no SNPs had genome-wide significant association with sinus bradycardia induced by SGAs. The top GWAS hit located in gene KIAA0247, which mainly regulated by the tumor suppressor P53 and thus plays a role in carcinogenesis based on resent research and it should not be a susceptibility locus to sinus bradycardia induced by SGAs. Using gene-set functional analysis, we tested that if top 500 SNPs mapped genes were relevant to sinus bradycardia. The result of gene prioritization analysis showed CTNNA3 was strongly correlated with sinus bradycardia, hinting it was a susceptibility gene of this ADR. Our study provides a preliminary study of genetic variants associated with sinus bradycardia induced by SGAs in Han Chinese SCZ patients. The discovery of a possible susceptibility gene shed light on further study of this adverse drug reaction in Han Chinese SCZ patients.

scholarly journals A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides

2014 ◽  
Vol 74 (3) ◽  
pp. e15-e15 ◽  
Author(s):  
L Bossini-Castillo ◽  
C de Kovel ◽  
H Kallberg ◽  
R van ‘t Slot ◽  
A Italiaander ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study

2009 ◽  
Vol 207 (1) ◽  
pp. 144-149 ◽  
Author(s):  
Yoshiji Yamada ◽  
Noriyuki Fuku ◽  
Masashi Tanaka ◽  
Yukitoshi Aoyagi ◽  
Motoji Sawabe ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Susceptibility Gene ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Identification ofIRX1as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study

2016 ◽  
Vol 68 (6) ◽  
pp. 1384-1391 ◽  
Author(s):  
Antonio Julià ◽  
Francisco Blanco ◽  
Benjamín Fernández-Gutierrez ◽  
Antonio González ◽  
Juan D. Cañete ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Rheumatoid Factor ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome ◽  
Risk Locus

scholarly journals A genome-wide association study identifiesSLC8A3as a susceptibility locus for ACPA-positive rheumatoid arthritis

Rheumatology ◽  
2016 ◽  
Vol 55 (6) ◽  
pp. 1106-1111 ◽  
Author(s):  
Antonio Julià ◽  
Isidoro González ◽  
Antonio Fernández-Nebro ◽  
Francisco Blanco ◽  
Luis Rodriguez ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Genome Wide ◽  
A Genome
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