scholarly journals Identification of a susceptibility locus inSTAT4for Behçet's disease in Han Chinese in a genome-wide association study

2012 ◽  
Vol 64 (12) ◽  
pp. 4104-4113 ◽  
Author(s):  
Shengping Hou ◽  
Zhenglin Yang ◽  
Liping Du ◽  
Zhengxuan Jiang ◽  
Qinmeng Shu ◽  
...  
Keyword(s):  
Association Study ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Susceptibility Locus ◽  
Behcet's Disease ◽  
Genome Wide ◽  
A Genome

scholarly journals Identification of novel genetic susceptibility loci for Behçet's disease using a genome-wide association study

2009 ◽  
Vol 11 (3) ◽  
pp. R66 ◽  
Author(s):  
Yiping Fei ◽  
Ryan Webb ◽  
Beth L Cobb ◽  
Haner Direskeneli ◽  
Güher Saruhan-Direskeneli ◽  
...  
Keyword(s):  
Association Study ◽  
Genetic Susceptibility ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Susceptibility Loci ◽  
Behcet's Disease ◽  
Genome Wide ◽  
A Genome

scholarly journals Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Behçet's disease

2010 ◽  
Vol 42 (8) ◽  
pp. 698-702 ◽  
Author(s):  
Elaine F Remmers ◽  
Fulya Cosan ◽  
Yohei Kirino ◽  
Michael J Ombrello ◽  
Neslihan Abaci ◽  
...  
Keyword(s):  
Association Study ◽  
Mhc Class I ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Genome Wide Association Study ◽  
Behçet's Disease ◽  
Genome Wide Association ◽  
Class I ◽  
Behcet's Disease ◽  
Genome Wide

scholarly journals Genome-wide association study of antipsychotic-induced sinus bradycardia in Chinese schizophrenia patients

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249997
Author(s):  
Saizheng Weng ◽  
Bo Wang ◽  
Mo Li ◽  
Shan Chao ◽  
Ruiqian Lin ◽  
...  
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Sinus Bradycardia ◽  
Susceptibility Gene ◽  
Han Chinese ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Second-generation antipsychotics (SGAs) play a critical role in current treatment of schizophrenia (SCZ). It has been observed that sinus bradycardia, rare but in certain situations life threatening adverse drug reaction, can be induced by SGAs across different schizophrenia populations. However, the roles of genetic factors in this phenomenon have not been studied yet. In the present study, a genome-wide association study of single nucleotide polymorphisms (SNPs) was performed on Chinese Han SCZ patients to identify susceptibility loci that were associated with sinus bradycardia induced by SGAs. This study applied microarray to obtain genotype profiles of 88 Han Chinese SCZ patients. Our results found that there were no SNPs had genome-wide significant association with sinus bradycardia induced by SGAs. The top GWAS hit located in gene KIAA0247, which mainly regulated by the tumor suppressor P53 and thus plays a role in carcinogenesis based on resent research and it should not be a susceptibility locus to sinus bradycardia induced by SGAs. Using gene-set functional analysis, we tested that if top 500 SNPs mapped genes were relevant to sinus bradycardia. The result of gene prioritization analysis showed CTNNA3 was strongly correlated with sinus bradycardia, hinting it was a susceptibility gene of this ADR. Our study provides a preliminary study of genetic variants associated with sinus bradycardia induced by SGAs in Han Chinese SCZ patients. The discovery of a possible susceptibility gene shed light on further study of this adverse drug reaction in Han Chinese SCZ patients.

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