Difference in subchondral cancellous bone between postmenopausal women with hip osteoarthritis and osteoporotic fracture: Implication for fatigue microdamage, bone microarchitecture, and biomechanical properties

2012 ◽  
Vol 64 (12) ◽  
pp. 3955-3962 ◽  
Author(s):  
Zhan-Chun Li ◽  
Li-Yang Dai ◽  
Lei-Sheng Jiang ◽  
Shijing Qiu
Keyword(s):  
Postmenopausal Women ◽  
Cancellous Bone ◽  
Osteoporotic Fracture ◽  
Bone Microarchitecture ◽  
Hip Osteoarthritis ◽  
Biomechanical Properties ◽  
Fatigue Microdamage

Comparison of 2D and 3D bone microarchitecture evaluation at the femoral neck, among postmenopausal women with hip fracture or hip osteoarthritis

Bone ◽  
2011 ◽  
Vol 49 (5) ◽  
pp. 1055-1061 ◽  
Author(s):  
Stéphanie Boutroy ◽  
Nicolas Vilayphiou ◽  
Jean-Paul Roux ◽  
Pierre D. Delmas ◽  
Hubert Blain ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Microarchitecture ◽  
Hip Osteoarthritis ◽  
2D And 3D

Assessment of 3D bone microarchitecture in femoral neck from postmenopausal women with hip fracture or hip osteoarthritis

Bone ◽  
2009 ◽  
Vol 44 ◽  
pp. S121-S122
Author(s):  
S. Boutroy ◽  
N. Vilayphiou ◽  
J. Roux ◽  
H. Blain ◽  
P.D. Delmas ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Microarchitecture ◽  
Hip Osteoarthritis

scholarly journals High osteoporotic fracture risk and CVD risk co-exist in postmenopausal women

Bone ◽  
2013 ◽  
Vol 52 (1) ◽  
pp. 120-125 ◽  
Author(s):  
Joanna Makovey ◽  
Monique Macara ◽  
Jian Sheng Chen ◽  
Christopher S. Hayward ◽  
Lyn March ◽  
...  
Keyword(s):  
Fracture Risk ◽  
Postmenopausal Women ◽  
Osteoporotic Fracture ◽  
Cvd Risk

scholarly journals Enhanced trabecular micro-architecture of the femoral neck in hip osteoarthritis vs. healthy controls: a micro-computer tomography study in postmenopausal women

2012 ◽  
Vol 37 (1) ◽  
pp. 21-26 ◽  
Author(s):  
Marija Djuric ◽  
Slavisa Zagorac ◽  
Petar Milovanovic ◽  
Danijela Djonic ◽  
Slobodan Nikolic ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Postmenopausal Women ◽  
Computer Tomography ◽  
Hip Osteoarthritis ◽  
Healthy Controls

Zoledronic Acid Substantially Improves Bone Microarchitecture and Biomechanical Properties After Rotator Cuff Repair in a Rodent Chronic Defect Model

2020 ◽  
Vol 48 (9) ◽  
pp. 2151-2160
Author(s):  
Jakob E. Schanda ◽  
Claudia Keibl ◽  
Patrick Heimel ◽  
Xavier Monforte ◽  
Stefan Tangl ◽  
...  
Keyword(s):  
Zoledronic Acid ◽  
Rotator Cuff ◽  
Humeral Head ◽  
Bone Microarchitecture ◽  
Intervention Group ◽  
Maximum Load ◽  
Biomechanical Properties ◽  
Rotator Cuff Tears ◽  
Mineral Density ◽  
Load To Failure

Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. Bone loss in the humeral head is associated with repair failure after rotator cuff reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone mineral density. Hypothesis: Zoledronic acid improves bone mineral density of the humeral head and biomechanical properties of the enthesis after reconstruction of chronic rotator cuff tears in rats. Study Design: Controlled laboratory study. Methods: A total of 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy with delayed transosseous rotator cuff reconstruction after 3 weeks. All rats were sacrificed 8 weeks after rotator cuff repair. Animals were randomly assigned to 1 of 2 groups. At 1 day after rotator cuff reconstruction, the intervention group was treated with a single subcutaneous dose of zoledronic acid at 100 µg/kg bodyweight, and the control group received 1 mL of subcutaneous saline solution. In 12 animals of each group, micro–computed tomography scans of both shoulders were performed as well as biomechanical testing of the supraspinatus enthesis of both sides. In 4 animals of each group, histological analyses were conducted. Results: In the intervention group, bone volume fraction (bone volume/total volume [BV/TV]) of the operated side was higher at the lateral humeral head ( P = .005) and the medial humeral head ( P = .010) compared with the control group. Trabecular number on the operated side was higher at the lateral humeral head ( P = .004) and the medial humeral head ( P = .001) in the intervention group. Maximum load to failure rates on the operated side were higher in the intervention group ( P < .001). Cortical thickness positively correlated with higher maximum load to failure rates in the intervention group ( r = 0.69; P = .026). Histological assessment revealed increased bone formation in the intervention group. Conclusion: Single-dose therapy of zoledronic acid provided an improvement of bone microarchitecture at the humeral head as well as an increase of maximum load to failure rates after transosseous reconstruction of chronic rotator cuff lesions in rats. Clinical Relevance: Zoledronic acid improves bone microarchitecture as well as biomechanical properties after reconstruction of chronic rotator cuff tears in rodents. These results need to be verified in clinical investigations.

scholarly journals Increased femoral neck cancellous bone and connectivity in coxarthrosis (hip osteoarthritis)

Bone ◽  
2003 ◽  
Vol 32 (1) ◽  
pp. 86-95 ◽  
Author(s):  
G.R Jordan ◽  
N Loveridge ◽  
K.L Bell ◽  
J Power ◽  
G.R Dickson ◽  
...  
Keyword(s):  
Femoral Neck ◽  
Cancellous Bone ◽  
Hip Osteoarthritis
Sign in / Sign up

Export Citation Format

Share Document