Endogenous activation of adaptive immunity: Tenascin-C drives interleukin-17 synthesis in murine arthritic joint disease

2012 ◽  
Vol 64 (7) ◽  
pp. 2179-2190 ◽  
Author(s):  
Michaela Ruhmann ◽  
Anna M. Piccinini ◽  
Philip L. Kong ◽  
Kim S. Midwood
Keyword(s):  
Adaptive Immunity ◽  
Joint Disease ◽  
Interleukin 17 ◽  
Arthritic Joint ◽  
Tenascin C

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

2009 ◽  
Vol 15 (7) ◽  
pp. 774-780 ◽  
Author(s):  
Kim Midwood ◽  
Sandra Sacre ◽  
Anna M Piccinini ◽  
Julia Inglis ◽  
Annette Trebaul ◽  
...  
Keyword(s):  
Joint Disease ◽  
Toll Like Receptor ◽  
Arthritic Joint ◽  
Toll Like Receptor 4 ◽  
Tenascin C

scholarly journals Interleukin-17/Interleukin-17 Receptor-Mediated Signaling Is Important for Generation of an Optimal Polymorphonuclear Response against Toxoplasma gondii Infection

2005 ◽  
Vol 73 (1) ◽  
pp. 617-621 ◽  
Author(s):  
Michelle N. Kelly ◽  
Jay K. Kolls ◽  
Kyle Happel ◽  
Joseph D. Schwartzman ◽  
Paul Schwarzenberger ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Adaptive Immunity ◽  
Protective Immunity ◽  
Polymorphonuclear Leukocytes ◽  
Early Infection ◽  
Interleukin 17 ◽  
Toxoplasma Gondii Infection ◽  
Knockout Animals

ABSTRACT We investigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protective immunity against Toxoplasma gondii. IL-17R−/− mice developed a normal adaptive immunity against the parasite. However, increased mortality in the knockout animals can be attributed to a defect in the migration of polymorphonuclear leukocytes to infected sites during early infection.

scholarly journals 114 TENASCIN-C LARGE, AN ELASTIC PROTEIN INDICATING JOINT DISEASE/INJURY IN HUMANS & PRECLINICAL ANIMAL MODELS

2009 ◽  
Vol 17 ◽  
pp. S68-S69
Author(s):  
L. Patel ◽  
W. Sun ◽  
S. Glasson ◽  
K.E. Georgiadis ◽  
E.A. Morris ◽  
...  
Keyword(s):  
Animal Models ◽  
Joint Disease ◽  
Tenascin C ◽  
Elastic Protein ◽  
Preclinical Animal Models

scholarly journals Did Tenascin-C Co-Evolve With the General Immune System of Vertebrates?

2021 ◽  
Vol 12 ◽  
Author(s):  
Gertraud Orend ◽  
Richard P. Tucker
Keyword(s):  
Extracellular Matrix ◽  
Adaptive Immunity ◽  
Lymphoid Tissues ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Tenascin C ◽  
Histocompatibility Complex ◽  
Reticular Fibers ◽  
Regulatory Functions ◽  
Lymphocyte Receptors

Tenascin-C plays important roles in immunity. Toll-like receptor 4, integrin α9β1 and chemokines have already been identified as key players in executing the immune regulatory functions of tenascin-C. Tenascin-C is also found in reticular fibers in lymphoid tissues, which are major sites involved in the regulation of adaptive immunity. Did the “tool box” for reading and interpreting the immune-regulating instructions imposed by tenascins and tenascin-C co-evolve? Though the extracellular matrix is ancient, tenascins evolved relatively recently. Tenascin-like genes are first encountered in cephalochordates and urochordates, which are widely accepted as the early branching chordate lineages. Vertebrates lacking jaws like the lamprey have tenascins, but a tenascin gene that clusters in the tenascin-C clade first appears in cartilaginous fish. Adaptive immunity apparently evolved independently in jawless and jawed vertebrates, with the former using variable lymphocyte receptors for antigen recognition, and the latter using immunoglobulins. Thus, while tenascins predate the appearance of adaptive immunity, the first tenascin-C appears to have evolved in the first organisms with immunoglobulin-based adaptive immunity. While a C-X-C chemokine is present in the lamprey, C-C chemokines also appear in the first organisms with immunoglobulin-based adaptive immunity, as does the major histocompatibility complex, T-cell receptors, Toll-like receptor 4 and integrin α9β1. Given the importance of tenascin-C in inflammatory events, the co-evolution of tenascin-C and key elements of adaptive and innate immunity is suggestive of a fundamental role for this extracellular matrix glycoprotein in the immune response of jawed vertebrates.

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