scholarly journals A graphic demonstration that the Disease Activity Score in 28 joints using the erythrocyte sedimentation rate is overly sensitive when erythrocyte sedimentation rates are low: Comment on the article by Smolen and Aletaha

2011 ◽  
Vol 63 (7) ◽  
pp. 2149-2149 ◽  
Author(s):  
Kazuki Yoshida ◽  
Kazuo Matsui ◽  
Hideto Oshikawa ◽  
Masako Utsunomiya ◽  
Tatsuo Kobayashi ◽  
...  
Keyword(s):  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Disease Activity Score ◽  
Activity Score ◽  
Sedimentation Rates ◽  
Erythrocyte Sedimentation ◽  
Erythrocyte Sedimentation Rates

The maximum dose and duration in the therapy single use methotrexate to achieve remission by rheumatoid arthritis patients through disease activity score 28 (DAS28)

2021 ◽  
Vol 32 (4) ◽  
pp. 675-680
Author(s):  
Anisyah Achmad ◽  
Tika Yasmin Rahmayanti ◽  
Bagus Putu Putra Suryana
Keyword(s):  
Rheumatoid Arthritis ◽  
Disease Activity ◽  
Erythrocyte Sedimentation Rate ◽  
Sedimentation Rate ◽  
Disease Activity Score ◽  
Maximum Dose ◽  
Activity Score ◽  
Erythrocyte Sedimentation ◽  
Length Of Therapy ◽  
Therapy Methotrexate

Abstract Objectives One of the treatments for rheumatoid arthritis (RA) was methotrexate which a disease modifying antirheumatic drug therapy. The use of methotrexate required the right dose and length of therapy to achieve remission. The effectivity of methotrexate could be accounted by disease activity score 28 (DAS28) as a tool has been used clinically with a combination number of tender joints, swollen joints, erythrocyte sedimentation rate, and global clinical assessment by the patient. The aim of this study was to determine the effective dose and length of therapy methotrexate was measured by DAS28 score. Methods This research was a cross-sectional study and data was collected from patient medical records in Saiful Anwar Hospital, Malang, from February to July 2018. The research has been given ethical clearance. The inclusion criteria for the 88 subjects were men and women, over 20 years of age, usage of only methotrexate for at least three months, an erythrocyte sedimentation rate score, uncomplicated inflammatory bowel disease, cancer, and systemic lupus erythematosus. All data obtained was entered in formula DAS28. The Statistic analysis used both Pearson and Spearman’s rank correlation. Results Only 16 patients achieved remission. There were not significant correlation in statistical analysis between DAS score and cumulative dose (r=−0.091; p=0.400), average dose (r=0.043; p = 0.692), maximum dose (r=0.074; p=0.492), and length of therapy (r=−0.075; p = 0.489). The initial dose of therapy methotrexate was different and the length of therapy was adjusted to the patient’s health condition. Conclusions The maximum dose and length of therapy methotrexate was required to achieve remission in RA.

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