Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis

2011 ◽  
Vol 63 (6) ◽  
pp. 1668-1680 ◽  
Author(s):  
Min-Jung Park ◽  
Hyun-Sil Park ◽  
Mi-La Cho ◽  
Hye-Joa Oh ◽  
Young-Gue Cho ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factor ◽  
Th17 Cells ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Autoimmune Arthritis ◽  
Reciprocal Regulation ◽  
Experimental Autoimmune

scholarly journals Expression of transforming growth factor β receptor II in mesenchymal stem cells from systemic sclerosis patients

BMJ Open ◽  
2013 ◽  
Vol 3 (1) ◽  
pp. e001890 ◽  
Author(s):  
Valérie Vanneaux ◽  
Dominique Farge-Bancel ◽  
Séverine Lecourt ◽  
Julie Baraut ◽  
Audrey Cras ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Systemic Sclerosis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Β Receptor

Allogeneic mesenchymal stem cells and growth factors in gel scaffold repair osteochondral defect in rabbit

2020 ◽  
Vol 15 (2) ◽  
pp. 1261-1275 ◽  
Author(s):  
Mudasir Bashir Gugjoo ◽  
Amarpal ◽  
Ahmed Abdelbaset-Ismail ◽  
Hari Prasad Aithal ◽  
Prakash Kinjavdekar ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Collagen Gel ◽  
Transforming Growth Factor Β ◽  
Saline Group ◽  
Group B ◽  
Group D

Aim: An attempt was made to improve osteochondral healing with allogeneic mesenchymal stem cells (MSCs) along with certain growth factors. Materials & methods: Induced knee osteochondral defects were filled as: phosphate buffer saline (group A); MSCs in collagen gel (group B); group B plus insulin like growth factor-1 (group C); group C plus transforming growth factor β-1 (group D). Results: Gross and scanning electron microscopy showed superior morphology and surface architecture of the healed tissue in groups D and C. Histologically, group D revealed hyaline cartilage characteristic features followed in order by group C and group B. In all treatment groups, chondrogenic matrix, collagen II2B ( col II 2B) and aggrecan were secreted. Conclusion: Combined use of MSCs and growth factors could accelerate osteochondral healing.

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