Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses

2010 ◽  
Vol 62 (12) ◽  
pp. 3656-3665 ◽  
Author(s):  
Jeroen N. Stoop ◽  
Rachel A. Harry ◽  
Alexei von Delwig ◽  
John D. Isaacs ◽  
John H. Robinson ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Therapeutic Effect ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

scholarly journals Synergistic Effect of Tolerogenic Dendritic Cells and Etanercept on a Collagen-induced Arthritis Animal Model

2019 ◽  
Vol 28 (3) ◽  
pp. 265-272
Author(s):  
Sang Youn Jung ◽  
Kil-Sang Cho ◽  
Doo-Rye Jang ◽  
Jun-Ho Lee ◽  
So-Yeon Choi ◽  
...  
Keyword(s):  
Animal Model ◽  
Dendritic Cells ◽  
Synergistic Effect ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

scholarly journals Antigen-Specific Tolerogenic Dendritic Cells Ameliorate the Severity of Murine Collagen-Induced Arthritis

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0131152 ◽  
Author(s):  
Bin Ning ◽  
Jianlu Wei ◽  
Aijun Zhang ◽  
Weiming Gong ◽  
Jinqiu Fu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

Synergistic therapeutic effect of mesenchymal stem cells and tolerogenic dendritic cells in an acute colitis mouse model

2020 ◽  
Vol 88 ◽  
pp. 107006
Author(s):  
Hajar Abbasi-Kenarsari ◽  
Neda Heidari ◽  
Kaveh Baghaei ◽  
Davar Amani ◽  
Mohammad Reza Zali ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
Mouse Model ◽  
Therapeutic Effect ◽  
Acute Colitis ◽  
Tolerogenic Dendritic Cells

scholarly journals STAT3 Activation in Combination with NF-KappaB Inhibition Induces Tolerogenic Dendritic Cells with High Therapeutic Potential to Attenuate Collagen-Induced Arthritis

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Carolina Prado ◽  
Valentina Ugalde ◽  
Hugo González ◽  
Alicia Figueroa ◽  
Ernesto López ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Therapeutic Potential ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells ◽  
Nf Kappab ◽  
Stat3 Signalling ◽  
Inflammatory Phenotypes ◽  
Significant Therapeutic Effect ◽  
Constitutively Active

Dendritic cells (DCs) have the ability to induce tolerance or inflammation in response to self-antigens, which makes them fundamental players in autoimmunity. In this regard, immunogenic DCs produce IL-12 and IL-23 favouring the acquisition of Th1 and Th17 inflammatory phenotypes, respectively, by autoreactive CD4+ T-cells, thus promoting autoimmunity. Conversely, tolerogenic DCs produce IL-10 and TGF-β, inducing the generation of CD4+ T-cells with suppressive activity (Treg), which promote tolerance to self-constituents. Previous studies have shown that STAT3 signalling in DCs attenuates the production of proinflammatory cytokines, whilst NF-κB activation promotes it. In this study, we aimed to generate DCs displaying strong and constitutive tolerogenic profile to be used as immunotherapy in autoimmunity. To this end, we transduced bone marrow-derived DCs with lentiviral particles codifying for a constitutively active version of STAT3 (constitutively active STAT3 (STAT3ca)) or with a constitutive repressor of NF-κB (IκBα superrepressor (IκBαSR)), and their therapeutic potential was evaluated in a mouse model of arthritis induced by collagen (CIA). Our results show that STAT3ca transduction favoured the production of the anti-inflammatory mediator IL-10, whereas IκBαSR transduction attenuated the expression of the proinflammatory cytokine IL-23 in DCs. Moreover, both STAT3ca-transduced and IκBαSR-transduced DCs separately exerted a mild but significant therapeutic effect reducing the severity of CIA development. Furthermore, when DCs were transduced with both STAT3ca and IκBαSR together, they reduced CIA manifestation significantly stronger than when transduced with only STAT3ca or IκBαSR separately. These results show STAT3 and NF-κB as two important and complementary regulators of the tolerogenic behaviour of DCs, which should be considered as molecular targets in the design of DC-based suppressive immunotherapies for the treatment of autoimmune disorders.

DiR-labeled tolerogenic dendritic cells for targeted imaging in collagen- induced arthritis rats

2021 ◽  
Vol 91 ◽  
pp. 107273
Author(s):  
Yaling Tian ◽  
Ping Shi ◽  
Yan Zhou ◽  
Rui Yuan ◽  
Zhicheng Hu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Targeted Imaging ◽  
Collagen Induced Arthritis ◽  
Tolerogenic Dendritic Cells

HIV-Antigens Charged on Phosphorus Dendrimers as Tools for Tolerogenic Dendritic Cells-Based Immunotherapy

2014 ◽  
Vol 21 (16) ◽  
pp. 1898-1909 ◽  
Author(s):  
Enrique Vacas-Cordoba ◽  
Hugo Bastida ◽  
Marjorie Pion ◽  
Aurelien Hameau ◽  
Maksim Ionov ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tolerogenic Dendritic Cells

scholarly journals 1,25-dihydroxyvitamin D3 induces stable and reproducible therapeutic tolerogenic dendritic cells with specific epigenetic modifications

Cytotherapy ◽  
2021 ◽  
Vol 23 (3) ◽  
pp. 242-255
Author(s):  
Kayleigh M. van Megen ◽  
Zhuo Chen ◽  
Antoinette M. Joosten ◽  
Sandra Laban ◽  
Jaap-Jan Zwaginga ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Epigenetic Modifications ◽  
Dihydroxyvitamin D3 ◽  
1,25 Dihydroxyvitamin D3 ◽  
Tolerogenic Dendritic Cells
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