Interferon-γ-dependent inhibition of B cell activation by bone marrow-derived mesenchymal stem cells in a murine model of systemic lupus erythematosus

2010 ◽  
Vol 62 (9) ◽  
pp. 2776-2786 ◽  
Author(s):  
Francesca Schena ◽  
Claudio Gambini ◽  
Andrea Gregorio ◽  
Manuela Mosconi ◽  
Daniele Reverberi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Lupus Erythematosus ◽  
Cell Activation ◽  
Interferon Γ ◽  
B Cell Activation ◽  
Systemic Lupus ◽  
Dependent Inhibition

scholarly journals p53/p21 Pathway Involved in Mediating Cellular Senescence of Bone Marrow-Derived Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-13 ◽  
Author(s):  
Zhifeng Gu ◽  
Jinxia Jiang ◽  
Wei Tan ◽  
Yunfei Xia ◽  
Haixia Cao ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Cellular Senescence ◽  
Lupus Erythematosus ◽  
Cyclin E ◽  
Cyclin Dependent Kinase ◽  
Systemic Lupus ◽  
Underlying Mechanisms

Our and other groups have found that bone marrow-derived mesenchymal stem cells (BM-MSCs) from systemic lupus erythematosus (SLE) patients exhibited senescent behavior and are involved in the pathogenesis of SLE. Numerous studies have shown that activation of the p53/p21 pathway inhibits the proliferation of BM-MSCs. The aim of this study was to determine whether p53/p21 pathway is involved in regulating the aging of BM-MSCs from SLE patients and the underlying mechanisms. We further confirmed that BM-MSCs from SLE patients showed characteristics of senescence. The expressions of p53 and p21 were significantly increased, whereas levels of Cyclin E, cyclin-dependent kinase-2, and phosphorylation of retinoblastoma protein were decreased in the BM-MSCs from SLE patients and knockdown of p21 expression reversed the senescent features of BM-MSCs from SLE patients. Our results demonstrated that p53/p21 pathway played an important role in the senescence process of BM-MSCs from SLE.

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