scholarly journals Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis

2010 ◽  
Vol 62 (8) ◽  
pp. 2499-2509 ◽  
Author(s):  
Jay Mehta ◽  
Anna Genin ◽  
Michael Brunner ◽  
Lisabeth V. Scalzi ◽  
Nilamadhab Mishra ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cell Activity ◽  
Nuclear Factor ◽  
Activated T Cell ◽  
Pediatric Lupus

scholarly journals Combined Deficiency of p50 and cRel in CD4+ T Cells Reveals an Essential Requirement for Nuclear Factor κB in Regulating Mature T Cell Survival and In Vivo Function

2003 ◽  
Vol 197 (7) ◽  
pp. 861-874 ◽  
Author(s):  
Ye Zheng ◽  
Monika Vig ◽  
Jesse Lyons ◽  
Luk Van Parijs ◽  
Amer A. Beg
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cd4 T Cells ◽  
Cell Function ◽  
Nuclear Factor ◽  
T Cell Function ◽  
T Cell Survival

Signaling pathways involved in regulating T cell proliferation and survival are not well understood. Here we have investigated a possible role of the nuclear factor (NF)-κB pathway in regulating mature T cell function by using CD4+ T cells from p50−/− cRel−/− mice, which exhibit virtually no inducible κB site binding activity. Studies with these mice indicate an essential role of T cell receptor (TCR)-induced NF-κB in regulating interleukin (IL)-2 expression, cell cycle entry, and survival of T cells. Our results further indicate that NF-κB regulates TCR-induced expression of antiapoptotic Bcl-2 family members. Strikingly, retroviral transduction of CD4+ T cells with the NF-κB–inducing IκB kinase β showed that NF-κB activation is not only necessary but also sufficient for T cell survival. In contrast, our results indicate a lack of involvement of NF-κB in both IL-2 and Akt-induced survival pathways. In vivo, p50−/− cRel−/− mice showed impaired superantigen-induced T cell responses as well as decreased numbers of effector/memory and regulatory CD4+ T cells. These findings provide the first demonstration of a role for NF-κB proteins in regulating T cell function in vivo and establish a critically important function of NF-κB in TCR-induced regulation of survival.

scholarly journals Follicular B helper T cell activity is confined to CXCR5hiICOShi CD4 T cells and is independent of CD57 expression

2006 ◽  
Vol 36 (7) ◽  
pp. 1892-1903 ◽  
Author(s):  
Ata-Ur Rasheed ◽  
Hans-Peter Rahn ◽  
Federica Sallusto ◽  
Martin Lipp ◽  
Gerd Müller
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cell Activity ◽  
Helper T Cell

Induction of tolerance in freshly isolated alloreactive CD4+ T cells by activated T cell stimulators

1994 ◽  
Vol 24 (10) ◽  
pp. 2457-2461 ◽  
Author(s):  
Ebenezer Satyaraj ◽  
Satyajit Rath ◽  
Vineeta Bal
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Activated T Cell ◽  
Induction Of Tolerance

scholarly journals Nuclear Factor of Activated T-cell Activity Is Associated with Metastatic Capacity in Colon Cancer

2014 ◽  
Vol 74 (23) ◽  
pp. 6947-6957 ◽  
Author(s):  
Manish K. Tripathi ◽  
Natasha G. Deane ◽  
Jing Zhu ◽  
Hanbing An ◽  
Shinji Mima ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Cell Activity ◽  
Nuclear Factor ◽  
Activated T Cell ◽  
Metastatic Capacity
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