scholarly journals Proteomic analysis by two-dimensional electrophoresis to identify the normal human chondrocyte proteome stimulated by tumor necrosis factor α and interleukin-1β

2010 ◽  
Vol 62 (3) ◽  
pp. 802-814 ◽  
Author(s):  
Berta Cillero-Pastor ◽  
Cristina Ruiz-Romero ◽  
Beatriz Caramés ◽  
María J. López-Armada ◽  
Francisco J. Blanco
Keyword(s):  
Tumor Necrosis Factor ◽  
Proteomic Analysis ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Two Dimensional ◽  
Two Dimensional Electrophoresis ◽  
Normal Human ◽  
Factor Α ◽  
Dimensional Electrophoresis ◽  
Necrosis Factor

scholarly journals The HPV E7 oncoprotein inhibits tumor necrosis factor α-mediated apoptosis in normal human fibroblasts

Oncogene ◽  
2001 ◽  
Vol 20 (28) ◽  
pp. 3629-3640 ◽  
Author(s):  
David Alan Thompson ◽  
Valerie Zacny ◽  
Glenn Scott Belinsky ◽  
Marie Classon ◽  
Dana Leanne Jones ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Human Fibroblasts ◽  
E7 Oncoprotein ◽  
Hpv E7 ◽  
Normal Human ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Potential Anti-Skin Aging Effect of (-)-Catechin Isolated from the Root Bark of Ulmus davidiana var. japonica in Tumor Necrosis Factor-α-Stimulated Normal Human Dermal Fibroblasts

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 981 ◽  
Author(s):  
Sullim Lee ◽  
Jae Sik Yu ◽  
Hung Manh Phung ◽  
Jeong Gun Lee ◽  
Ki Hyun Kim ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Aging Effect ◽  
Skin Aging ◽  
Root Bark ◽  
Normal Human ◽  
Ulmus Davidiana ◽  
Factor Α ◽  
Necrosis Factor

Reactive oxygen species (ROS) are generated during skin aging, including intrinsic (chronologic aging) and extrinsic aging (photoaging). Therefore, antioxidants that inhibit ROS generation can delay skin aging. In this study, we evaluated the potential anti-skin aging effect of (-)-phenolic compounds isolated from the root bark of Ulmus davidiana var. japonica. We preferentially investigated the possible preventive effects of isolates against the degradation of skin extracellular matrix. Among the isolates, (-)-catechin suppressed the activity of collagenase MMP-1, and reversed the degradation of collagen induced by tumor necrosis factor-α (TNF-α) in normal human dermal fibroblast. This action mechanism of (-)-catechin was validated by the suppression of tumor necrosis factor-α-induced accumulation of ROS and activation of mitogen-activated protein kinases, protein kinase B (Akt), and cyclooxygenase-2 (COX-2). The proinflammatory cytokines upregulate inflammatory reactions, and ultimately promote aging-related reactions. In this milieu, we demonstrated that (-)-catechin decreased the expression and secretion of proinflammatory cytokines, including interleukin (IL)-1β and IL-6. In conclusion, (-)-catechin is a candidate to ameliorate both intrinsic and extrinsic skin aging.

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