scholarly journals Novel role of plasmacytoid dendritic cells in humans: Induction of interleukin-10–producing treg cells by plasmacytoid dendritic cells in patients with rheumatoid arthritis responding to therapy

2010 ◽  
Vol 62 (1) ◽  
pp. 53-63 ◽  
Author(s):  
Melina Kavousanaki ◽  
Antonis Makrigiannakis ◽  
Dimitrios Boumpas ◽  
Panayotis Verginis
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Treg Cells ◽  
Plasmacytoid Dendritic Cells

scholarly journals Eminent role of ICOS costimulation for T cells interacting with plasmacytoid dendritic cells

Immunology ◽  
2006 ◽  
Vol 118 (3) ◽  
pp. 353-360 ◽  
Author(s):  
Marko Janke ◽  
Esther J. Witsch ◽  
Hans W. Mages ◽  
Andreas Hutloff ◽  
Richard A. Kroczek
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells

scholarly journals Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells

PLoS ONE ◽  
2016 ◽  
Vol 11 (6) ◽  
pp. e0156063 ◽  
Author(s):  
Besma Aouar ◽  
Denisa Kovarova ◽  
Sebastien Letard ◽  
Albert Font-Haro ◽  
Jonathan Florentin ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Tyrosine Kinase ◽  
Plasmacytoid Dendritic Cells ◽  
Dual Role ◽  
Receptor Signaling ◽  
Toll Like Receptor

scholarly journals Correlation Between Immune Lymphoid Cells and Plasmacytoid Dendritic Cells in Human Colon Cancer

2020 ◽  
Author(s):  
Jing Wu ◽  
Hang Cheng ◽  
Tete Li ◽  
Helei Wang ◽  
Guoxia Zang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Dendritic Cells ◽  
Rna Sequencing ◽  
Immune Cells ◽  
Human Colon ◽  
Tumour Microenvironment ◽  
Plasmacytoid Dendritic Cells ◽  
Lymphoid Cells ◽  
Human Colon Cancer

Abstract Background: Innate lymphoid cells (ILCs), so far studied mostly in mouse models, are important tissue-resident innate immune cells that play important roles in the colorectal cancer microenvironment and maintain the mucosal tissue homeostasis. Plasmacytoid dendritic cells (pDCs) present complexity in various tumour types and are correlated with poor prognosis. pDCs can promote HIV-1–induced group 3 ILC (ILC3) depletion through the CD95 pathway. However, the role of ILC3s in human colon cancer and their correlation with other immune cells, especially pDCs, remain unclear. Methods: We characterised ILCs and pDCs in the tumour microenvironment of 58 colon cancer patients by flow cytometry and selected three patients for RNA sequencing. Results: ILC3s were negatively correlated, and pDCs were positively correlated, with cancer pathological grade. There was a negative correlation between the numbers of ILC3s and pDCs in tumour tissues. RNA sequencing confirmed the correlations between ILC3s and pDCs and highlighted the potential function of many ILC- and pDC-associated differentially expressed genes in the regulation of tumour immunity. pDCs can induce apoptosis of ILC3s through the CD95 pathway in the tumour microenvironment. Conclusions: One of the interactions between ILC3s and pDCs is via the CD95 pathway, which may help explain the role of ILC3s in colon cancer.

AB0450 Myeloid Dendritic Cells and Plasmacytoid Dendritic Cells as Possible Target for the Immunotherapy in Patients with Rheumatoid Arthritis

2014 ◽  
Vol 73 (Suppl 2) ◽  
pp. 957.1-957
Author(s):  
S.A. Falaleeva ◽  
V.V. Kurilin ◽  
N.S. Shkaruba ◽  
O.A. Chumasova ◽  
A.E. Sizikov ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells
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